Detalhe da pesquisa
1.
Novel pyrazole-based COX-2 inhibitors as potential anticancer agents: Design, synthesis, cytotoxic effect against resistant cancer cells, cell cycle arrest, apoptosis induction and dual EGFR/Topo-1 inhibition.
Bioorg Chem
; 131: 106273, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36444790
2.
Design, synthesis, anticancer evaluation, and in silico studies of some thieno[2,3-d]pyrimidine derivatives as EGFR inhibitors.
Drug Dev Res
; 84(6): 1299-1319, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37357422
3.
Synthesis and biological evaluation of halogenated phenoxychalcones and their corresponding pyrazolines as cytotoxic agents in human breast cancer.
J Enzyme Inhib Med Chem
; 37(1): 189-201, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34894967
4.
Design and synthesis of novel 4-fluorobenzamide-based derivatives as promising anti-inflammatory and analgesic agents with an enhanced gastric tolerability and COX-inhibitory activity.
Bioorg Chem
; 115: 105253, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34390973
5.
Uses of cyclohexane-1,3-dione for the synthesis of 1,2,4-triazine derivatives as anti-proliferative agents and tyrosine kinases inhibitors.
Bioorg Chem
; 97: 103667, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32087416
6.
Novel tetrazole-based selective COX-2 inhibitors: Design, synthesis, anti-inflammatory activity, evaluation of PGE2, TNF-α, IL-6 and histopathological study.
Bioorg Chem
; 104: 104308, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33011534
7.
Synthesis, and anti-proliferative, Pim-1 kinase inhibitors and molecular docking of thiophenes derived from estrone.
Bioorg Chem
; 83: 402-413, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30415021