Detalhe da pesquisa
1.
Discovery of oxindole-based FLT3 inhibitors as a promising therapeutic lead for acute myeloid leukemia carrying the oncogenic ITD mutation.
Arch Pharm (Weinheim)
; 356(2): e2200407, 2023 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-36403191
2.
Coumarin derivatives with potential anticancer and antibacterial activity: Design, synthesis, VEGFR-2 and DNA gyrase inhibition, and in silico studies.
Drug Dev Res
; 84(3): 433-457, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36779381
3.
Novel antiproliferative agents bearing substituted thieno[2,3-d]pyrimidine scaffold as dual VEGFR-2 and BRAF kinases inhibitors and apoptosis inducers; design, synthesis and molecular docking.
Bioorg Chem
; 125: 105861, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35569190
4.
Design, synthesis and mechanistic study of novel diarylpyrazole derivatives as anti-inflammatory agents with reduced cardiovascular side effects.
Bioorg Chem
; 116: 105394, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34619468
5.
Design, synthesis, anticancer evaluation, and molecular modelling studies of novel tolmetin derivatives as potential VEGFR-2 inhibitors and apoptosis inducers.
J Enzyme Inhib Med Chem
; 36(1): 922-939, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-33896327
6.
Computational Insights on the Potential of Some NSAIDs for Treating COVID-19: Priority Set and Lead Optimization.
Molecules
; 26(12)2021 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34205704
7.
Turn-on fluorescence of mirabegron for its sensitive detection in human plasma: Box-Behnken-Design for optimization.
Spectrochim Acta A Mol Biomol Spectrosc
; 316: 124372, 2024 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38703408
8.
A unique implementation of Hantzsch reaction for determination of natamycin in Yoghurt: Hyphenated with Box-Behnken-design for optimization.
Spectrochim Acta A Mol Biomol Spectrosc
; 317: 124395, 2024 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38714004
9.
Nanocomposite alginate hydrogel loaded with propranolol hydrochloride kolliphor® based cerosomes as a repurposed platform for Methicillin-Resistant Staphylococcus aureus-(MRSA)-induced skin infection; in-vitro, ex-vivo, in-silico, and in-vivo evaluation.
Drug Deliv Transl Res
; 2024 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38762697
10.
Integration of terpesomes loaded Levocetrizine dihydrochloride gel as a repurposed cure for Methicillin-Resistant Staphylococcus aureus (MRSA)-Induced skin infection; D-optimal optimization, ex-vivo, in-silico, and in-vivo studies.
Int J Pharm
; 633: 122621, 2023 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36693486
11.
Exploring the Synergistic Effect of Bergamot Essential Oil with Spironolactone Loaded Nano-Phytosomes for Treatment of Acne Vulgaris: In Vitro Optimization, In Silico Studies, and Clinical Evaluation.
Pharmaceuticals (Basel)
; 16(1)2023 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36678625
12.
Repurposing levocetirizine hydrochloride loaded into cationic ceramide/phospholipid composite (CCPCs) for management of alopecia: central composite design optimization, in- silico and in-vivo studies.
Drug Deliv
; 29(1): 2784-2795, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36047012
13.
In a search for potential drug candidates for combating COVID-19: computational study revealed salvianolic acid B as a potential therapeutic targeting 3CLpro and spike proteins.
J Biomol Struct Dyn
; 40(19): 8866-8893, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-33928870
14.
Revisiting activity of some glucocorticoids as a potential inhibitor of SARS-CoV-2 main protease: theoretical study.
RSC Adv
; 11(17): 10027-10042, 2021 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35423530
15.
Spironolactone hyaluronic acid enriched cerosomes (HAECs) for topical management of hirsutism: in silico studies, statistical optimization, ex vivo, and in vivo studies.
Drug Deliv
; 28(1): 2289-2300, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34726545
16.
New Multi-Targeted Antiproliferative Agents: Design and Synthesis of IC261-Based Oxindoles as Potential Tubulin, CK1 and EGFR Inhibitors.
Pharmaceuticals (Basel)
; 14(11)2021 Oct 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34832895
17.
ß-Blockers bearing hydroxyethylamine and hydroxyethylene as potential SARS-CoV-2 Mpro inhibitors: rational based design, in silico, in vitro, and SAR studies for lead optimization.
RSC Adv
; 11(56): 35536-35558, 2021 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35493159