1.
Org Biomol Chem
; 22(11): 2226-2230, 2024 Mar 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38363281
RESUMO
An efficient intermolecular annulation of indazole aldehydes with propargylic amines has been developed for the synthesis of pyrazinoindazoles under catalyst- and additive-free conditions. This straightforward methodology was found to feature a wide substrate scope, high atom economy and environmental advantages. The bioactivity results of these new pyrazino[1,2-b]indazoles showed that some of them exhibited significant antifungal activity.