Experimental evaluation of aerosol mitigation strategies in large open-plan dental clinics.

BACKGROUND: Aerosols are generated routinely during patient care in dentistry. Managing exposure risk requires understanding characteristics of aerosols created during procedures such as those performed using high-speed drills that operate at 200,000 revolutions per minute. METHODS: A trained dentist performed drilling procedures on a manikin's incisors (teeth nos. 8 and 9) using a high-speed drill and high-volume evacuator. The authors used high-speed imaging to visualize the formation and transport of aerosol clouds and particle sampling to measure aerosol concentration and size distribution at several locations. The authors studied several aerosol mitigation strategies. RESULTS: Aerosols produced during high-speed drilling were erratic and yielded high concentrations that were at least an order of magnitude above baseline. High-speed imaging showed aerosols initially travelled at 1 m per second. Owing to erratic behavior of aerosols, supplemental suction was not effective at collecting all aerosols; however, barriers were effective. CONCLUSIONS: Barriers are the most effective mitigation strategy. Other methods studied have limitations and risks. To the authors' knowledge, this article presents the first characterization of aerosols generated during high-speed drilling by a dentist. PRACTICAL IMPLICATIONS: With thorough preoperative planning and the use of this investigation's findings about effectiveness of mitigation strategies as a guide, dental offices may be able to return to prepandemic productivity.

Disease transmission through expiratory aerosols on an urban bus.

Airborne respiratory diseases such as COVID-19 pose significant challenges to public transportation. Several recent outbreaks of SARS-CoV-2 indicate the high risk of transmission among passengers on public buses if special precautions are not taken. This study presents a combined experimental and numerical analysis to identify transmission mechanisms on an urban bus and assess strategies to reduce risk. The effects of the ventilation and air-conditioning systems, opening windows and doors, and wearing masks are analyzed. Specific attention is paid to the transport of submicron- and micron-sized particles relevant to typical respiratory droplets. High-resolution instrumentation was used to measure size distribution and aerosol response time on a campus bus of the University of Michigan under these different conditions. Computational fluid dynamics was employed to measure the airflow within the bus and evaluate risk. A risk metric was adopted based on the number of particles exposed to susceptible passengers. The flow that carries these aerosols is predominantly controlled by the ventilation system, which acts to uniformly distribute the aerosol concentration throughout the bus while simultaneously diluting it with fresh air. The opening of doors and windows was found to reduce the concentration by approximately one half, albeit its benefit does not uniformly impact all passengers on the bus due to the recirculation of airflow caused by entrainment through windows. Finally, it was found that well fitted surgical masks, when worn by both infected and susceptible passengers, can nearly eliminate the transmission of the disease.

NPCARE: database of natural products and fractional extracts for cancer regulation.

BACKGROUND: Natural products have increasingly attracted much attention as a valuable resource for the development of anticancer medicines due to the structural novelty and good bioavailability. This necessitates a comprehensive database for the natural products and the fractional extracts whose anticancer activities have been verified. DESCRIPTION: NPCARE (http://silver.sejong.ac.kr/npcare) is a publicly accessible online database of natural products and fractional extracts for cancer regulation. At NPCARE, one can explore 6578 natural compounds and 2566 fractional extracts isolated from 1952 distinct biological species including plants, marine organisms, fungi, and bacteria whose anticancer activities were validated with 1107 cell lines for 34 cancer types. Each entry in NPCARE is annotated with the cancer type, genus and species names of the biological resource, the cell line used for demonstrating the anticancer activity, PubChem ID, and a wealth of information about the target gene or protein. Besides the augmentation of plant entries up to 743 genus and 197 families, NPCARE is further enriched with the natural products and the fractional extracts of diverse non-traditional biological resources. CONCLUSIONS: NPCARE is anticipated to serve as a dominant gateway for the discovery of new anticancer medicines due to the inclusion of a large number of the fractional extracts as well as the natural compounds isolated from a variety of biological resources.