Detalhe da pesquisa
1.
A potent MAPK13-14 inhibitor prevents airway inflammation and mucus production.
Am J Physiol Lung Cell Mol Physiol
; 325(6): L726-L740, 2023 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37847710
2.
Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets.
Bioorg Med Chem
; 23(10): 2328-43, 2015 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25882520
3.
A potent MAPK13-14 inhibitor prevents airway inflammation and mucus production.
bioRxiv
; 2023 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37292761
4.
Combinatorial small-molecule therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice.
Antimicrob Agents Chemother
; 56(9): 4738-45, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22733070
5.
Discovery of Selective Matriptase and Hepsin Serine Protease Inhibitors: Useful Chemical Tools for Cancer Cell Biology.
J Med Chem
; 62(2): 480-490, 2019 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30571119
6.
Nonaromatic amidine derivatives as acylation catalysts.
Org Lett
; 9(1): 37-40, 2007 Jan 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-17192079
7.
Targeting the tumor-promoting microenvironment in MET-amplified NSCLC cells with a novel inhibitor of pro-HGF activation.
Oncotarget
; 8(38): 63014-63025, 2017 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28968967
8.
α-Ketobenzothiazole Serine Protease Inhibitors of Aberrant HGF/c-MET and MSP/RON Kinase Pathway Signaling in Cancer.
ChemMedChem
; 11(6): 585-99, 2016 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26889658
9.
Antivirulence C-Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract Infections.
J Med Chem
; 59(20): 9390-9408, 2016 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27689912
10.
Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI.
ChemMedChem
; 11(4): 367-73, 2016 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26812660
11.
Inhibitors of HGFA, Matriptase, and Hepsin Serine Proteases: A Nonkinase Strategy to Block Cell Signaling in Cancer.
ACS Med Chem Lett
; 5(11): 1219-24, 2014 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25408834
12.
Lead optimization studies on FimH antagonists: discovery of potent and orally bioavailable ortho-substituted biphenyl mannosides.
J Med Chem
; 55(8): 3945-59, 2012 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22449031
13.
Treatment and prevention of urinary tract infection with orally active FimH inhibitors.
Sci Transl Med
; 3(109): 109ra115, 2011 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-22089451
14.
Structure-based drug design and optimization of mannoside bacterial FimH antagonists.
J Med Chem
; 53(12): 4779-92, 2010 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-20507142
15.
Hexakis(4-(N-butylpyridylium))benzene: a six-electron organic redox system.
J Org Chem
; 73(2): 445-50, 2008 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-18085793
16.
A new method for the synthesis of acyltitanium complexes and their application to copper-mediated acylmetallation of carbon-carbon multiple bonds in aqueous media.
Org Biomol Chem
; 3(9): 1622-3, 2005 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-15858641