Detalhe da pesquisa
1.
Pharmacological properties and procognitive effects of ABT-288, a potent and selective histamine H3 receptor antagonist.
J Pharmacol Exp Ther
; 343(1): 233-45, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22815533
2.
In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series.
Bioorg Med Chem Lett
; 18(1): 355-9, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18077160
3.
An 80-amino acid deletion in the third intracellular loop of a naturally occurring human histamine H3 isoform confers pharmacological differences and constitutive activity.
J Pharmacol Exp Ther
; 323(3): 888-98, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17855474
4.
Synthesis, potency, and in vivo profiles of quinoline containing histamine H3 receptor inverse agonists.
J Med Chem
; 50(22): 5439-48, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17918921
5.
Novel heterocyclic-substituted benzofuran histamine H3 receptor antagonists: in vitro properties, drug-likeness, and behavioral activity.
Biochem Pharmacol
; 73(8): 1243-55, 2007 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17371699
6.
Detection of multiple H3 receptor affinity states utilizing [3H]A-349821, a novel, selective, non-imidazole histamine H3 receptor inverse agonist radioligand.
Br J Pharmacol
; 148(5): 657-70, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16715122
7.
Lack of efficacy of melanin-concentrating hormone-1 receptor antagonists in models of depression and anxiety.
Eur J Pharmacol
; 540(1-3): 115-20, 2006 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16765941
8.
Evidence for tolerance following repeated dosing in rats with ciproxifan, but not with A-304121.
Life Sci
; 79(14): 1366-79, 2006 Aug 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-16730751
9.
Synthesis and SAR of 5-amino- and 5-(aminomethyl)benzofuran histamine H3 receptor antagonists with improved potency.
J Med Chem
; 48(20): 6482-90, 2005 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-16190774
10.
4-(2-[2-(2(R)-methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and related 2-aminoethylbenzofuran H3 receptor antagonists potently enhance cognition and attention.
J Med Chem
; 48(1): 38-55, 2005 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-15634000
11.
Effects of histamine H3 receptor antagonists in two models of spatial learning.
Behav Brain Res
; 159(2): 295-300, 2005 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-15817192
12.
Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist.
J Med Chem
; 47(12): 3220-35, 2004 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-15163201
13.
Use of a fluorescent imaging plate reader--based calcium assay to assess pharmacological differences between the human and rat vanilloid receptor.
J Biomol Screen
; 7(5): 466-75, 2002 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-14599363
14.
Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist.
Biochem Pharmacol
; 68(5): 933-45, 2004 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15294456
15.
H3 receptor antagonists/inverse agonists as anti-obesity agents.
Curr Opin Investig Drugs
; 4(10): 1190-7, 2003 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-14649210
16.
H3 receptor blockade by thioperamide enhances cognition in rats without inducing locomotor sensitization.
Psychopharmacology (Berl)
; 167(4): 363-72, 2003 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12682709
17.
Medicinal chemistry and biological properties of non-imidazole histamine H3 antagonists.
Mini Rev Med Chem
; 4(9): 979-92, 2004 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-15544558
18.
Enhancement of prepulse inhibition of startle in mice by the H3 receptor antagonists thioperamide and ciproxifan.
Behav Brain Res
; 153(1): 69-76, 2004 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-15219708
19.
Effects of histamine H(3) receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup.
Behav Brain Res
; 131(1-2): 151-61, 2002 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-11844582
20.
Cloning and pharmacological characterization of the monkey histamine H3 receptor.
Eur J Pharmacol
; 482(1-3): 49-60, 2003 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-14660004