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1.
Ann Pathol ; 28(1): 2-8, 2008 Feb.
Artigo em Francês | MEDLINE | ID: mdl-18538708

RESUMO

In order to illustrate the clinical and histological presentations of laryngeal atypical carcinoids and their potential course, we report six cases. We evaluated the factors predictive of local recurrence and metastatic diffusion. For each case, we noted the mitotic index, the quality of the resection, the limits of the tumor and the presence of necrosis. An immunohistochemical study was carried out with a series of antibodies (cytokeratins; D(2)40; CD31; MIB1; P53; P16; TTF1...). The clinical presentation we observed was quite similar to that reported in the literature. These tumors are CK7+, CK8+, CK19+, CK5-6-, CK14- and CK20-. P16 is constantly positive. Only the mitotic index and the lymphatic presence of embolus were correlated with the time course. The tumor is more aggressive when the mitotic index is high and an unfavorable course is observed when there are lymphatic emboli or when the Ki67 index is higher than 5%.


Assuntos
Cartilagem Aritenoide/patologia , Tumor Carcinoide/cirurgia , Neoplasias Laríngeas/cirurgia , Idoso , Idoso de 80 Anos ou mais , Tumor Carcinoide/patologia , Feminino , Humanos , Neoplasias Laríngeas/patologia , Laringectomia , Masculino , Pessoa de Meia-Idade , Mitose
2.
Acta Orthop Belg ; 74(4): 562-5, 2008 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-18811047

RESUMO

Nora's tumour is an uncommon benign tumour, involving mostly tubular bones of hands and feet, and characterized by a proliferation of chondroid, bony and fibrous tissues. Main differential diagnoses are osteochondroma, chondrosarcoma, and osteosarcoma. The authors report a case involving the left foot. The diagnosis was suspected by imaging characteristic features and was confirmed by histological examination. Treatment was surgical, with complete excision. There are no clinical or radiological signs of recurrence on further review one year postoperatively.


Assuntos
Neoplasias Ósseas/patologia , Doenças do Pé/patologia , Osteocondroma/patologia , Periósteo , Adulto , Neoplasias Ósseas/cirurgia , Doenças do Pé/diagnóstico , Humanos , Masculino , Osteocondroma/cirurgia
3.
Acta Orthop Belg ; 74(1): 114-7, 2008 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-18411611

RESUMO

Lymphangioleiomyomatosis (LAM) is a rare condition usually occurring in young women of childbearing age. It is characterised by the presence of abnormal smooth muscle cells (LAM cells) in the lungs, lymph nodes, and/or other organs, with a few reports of isolated extrapulmonary cases. We report the case of a 26-yr-old female who presented with a painless shoulder mass. Ultrasonography, computed tomography and magnetic resonance imaging revealed an intermuscular mass with cystic and solid tissue components, measuring 6 cm x 4 cm. The mass was removed surgically after the diagnosis of LAM was made following tru-cut biopsy. This case corresponds to an exceptional localisation of LAM.


Assuntos
Linfangioleiomiomatose/diagnóstico , Neoplasias Musculares/diagnóstico , Ombro , Adulto , Feminino , Humanos , Linfangioleiomiomatose/patologia , Neoplasias Musculares/patologia
4.
Intern Med ; 46(7): 397-9, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-17409605

RESUMO

When ichthyosis occurs in adulthood, it may signify internal disease, especially malignant hemopathy. A 49-year-old man was admitted to hospital with diarrhea, fever, weight loss and abdominal pain. Physical examination showed generalized ichthyosis with palmoplantar hyperkeratosis and multiple inguinal lymph nodes. Laboratory investigations showed severe pancytopenia. Ultrasonography and CT scan demonstrated intraabdominal lymph node enlargement. Osteomedullary biopsy and open abdominal lymph node biopsy revealed an anaplastic large cell lymphoma. The lymph node involvement subsequently became worse and more severe, and the patient's general condition deteriorated. He died before receiving chemotherapy.


Assuntos
Ictiose/etiologia , Linfoma não Hodgkin/complicações , Linfoma não Hodgkin/diagnóstico , Síndromes Paraneoplásicas/etiologia , Biópsia por Agulha , Progressão da Doença , Evolução Fatal , Humanos , Ictiose/diagnóstico , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , Medição de Risco , Índice de Gravidade de Doença , Tomografia Computadorizada por Raios X
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