Detalhe da pesquisa
1.
The conformational change of the protease inhibitor α2-macroglobulin is triggered by the retraction of the cleaved bait region from a central channel.
J Biol Chem
; 298(8): 102230, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35787371
2.
Structural Investigations of Human A2M Identify a Hollow Native Conformation That Underlies Its Distinctive Protease-Trapping Mechanism.
Mol Cell Proteomics
; 20: 100090, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33964423
3.
Development of selective protease inhibitors via engineering of the bait region of human α2-macroglobulin.
J Biol Chem
; 297(1): 100879, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34139236
4.
Mutation-induced dimerization of transforming growth factor-ß-induced protein may drive protein aggregation in granular corneal dystrophy.
J Biol Chem
; 297(1): 100858, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34097874
5.
α2-Macroglobulin-like protein 1 can conjugate and inhibit proteases through their hydroxyl groups, because of an enhanced reactivity of its thiol ester.
J Biol Chem
; 295(49): 16732-16742, 2020 12 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32978260
6.
Substituting the Thiol Ester of Human A2M or C3 with a Disulfide Produces Native Proteins with Altered Proteolysis-Induced Conformational Changes.
Biochemistry
; 59(51): 4799-4809, 2020 12 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-33301305
7.
Recent cryogenic electron microscopy structures of human A2M may not be representative of the native protein.
Proc Natl Acad Sci U S A
; 119(37): e2210218119, 2022 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35972981
8.
Correction: α2-Macroglobulin-like protein 1 can conjugate and inhibit proteases through their hydroxyl groups, because of an enhanced reactivity of its thiol ester.
J Biol Chem
; 296: 100208, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33837737
9.
Efficacy and toxicity management of CAR-T-cell immunotherapy: a matter of responsiveness control or tumour-specificity?
Biochem Soc Trans
; 44(2): 406-11, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27068947
10.
Proteolytic cleavage of the TGFß co-receptor CD109 changes its conformation, resulting in protease inhibition via activation of its thiol ester, and dissociation from the cell membrane.
FEBS J
; 2024 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38587194
11.
Characterization of a novel cold-adapted intracellular serine protease from the extremophile Planococcus halocryophilus Or1.
Front Microbiol
; 14: 1121857, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36910232
12.
Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family.
Nat Commun
; 13(1): 3033, 2022 05 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-35641520
13.
Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer.
Oncoimmunology
; 11(1): 2034355, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35154908
14.
Carcinoembryonic Antigen (CEA)-Specific 4-1BB-Costimulation Induced by CEA-Targeted 4-1BB-Agonistic Trimerbodies.
Front Immunol
; 10: 1791, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31417564
15.
A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity.
Nat Commun
; 9(1): 4809, 2018 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30442944
16.
ATTACK, a novel bispecific T cell-recruiting antibody with trivalent EGFR binding and monovalent CD3 binding for cancer immunotherapy.
Oncoimmunology
; 7(1): e1377874, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29296540
17.
Intramolecular trimerization, a novel strategy for making multispecific antibodies with controlled orientation of the antigen binding domains.
Sci Rep
; 6: 28643, 2016 06 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27345490