Pharmacotherapeutic Potential of Bitter Gourd (Momordica charantia) in Age-related Neurological Diseases.

Due to the growth of the elderly population, age-related neurological disorders are an increasing problem. Aging begins very gradually and later leads to several neurological issues such as lower neurotransmitter levels, oxidative stress, neuronal inflammation, and continual neuronal loss. These changes might contribute to brain disorders such as Alzheimer's disease (AD), dementia or mild cognitive impairment, and epilepsy and glioma, and can also aggravate these disorders if they were previously present. Momordica charantia (bitter gourd), a member of the Cucurbitaceae family, is a good source of carbohydrates, proteins, vitamins, and minerals. It is used for diabetes and known for its hypoglycemic and antioxidant effects. In this review, we discuss the pharmaceutical effects of M. charantia on age-related neurological disorders. We searched several databases, including PubMed and Google Scholar, using MeSH terms. We searched articles published up until 2022 regardless of publication language. M. charantia is rich in luteolin, which increases acetylcholine in neurons by binding to enzymes in acetylcholine metabolism pathways, including butyrylcholinesterase and acetylcholinesterase. This binding inhibits the hyperphosphorylation of tau protein by restraining its kinase enzyme. Furthermore, this substance can lower serum cholesterol and has multi-target activity in AD and memory loss. M. charantia can also improve memory by decreasing tau protein and it also has potent antioxidant activity and anti-inflammatory effects. This review highlights that M. charantia has effects on many age-related neurological disorders, and can be a cost-effective supplement with minimal side effects.

Ultra-high voltage gain achieved with quadratic DC/DC converter design.

This work introduces a novel DC/DC converter with an incredibly high voltage gain, specifically designed for renewable energy generating systems. The proposed circuit features a coupled inductor integrated with a quadratic boost circuit and a voltage multiplier cell to achieve a substantial step-up in voltage gain. Ultra-high voltage gain, minimum reverse recovery in diodes, low voltage stress on switching devices, continuous input current, and a shared ground between the input source and output load are some of this topology's key features. The coupled inductor design reduces power dissipation in magnetic components by distributing the high DC source current with an additional input inductor. Additionally, regenerative clamp circuits alleviate voltage stresses on power switches during simultaneous switching. Theoretical analysis covering the operating principle, steady-state behavior, and efficiency is discussed in detail. An evaluation of the suggested topology's performance is conducted using a 250-W, 25-V/400-V lab prototype.