1.
ACS Med Chem Lett
; 1(9): 526-9, 2010 Dec 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24900242
RESUMO
HIF prolyl 4-hydroxylases (PHD) are a family of enzymes that mediate key physiological responses to hypoxia by modulating the levels of hypoxia inducible factor 1-α (HIF1α). Certain benzimidazole-2-pyrazole carboxylates were discovered to be PHD2 inhibitors using ligand- and structure-based methods and found to be potent, orally efficacious stimulators of erythropoietin secretion in vivo.