Detalhe da pesquisa
1.
Enhancing anticancer treatment: Development of cRGD-Conjugated F-OH-Evo prodrugs for targeted delivery.
Bioorg Med Chem
; 107: 117759, 2024 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38795572
2.
Cyclic peptide conjugated photosensitizer for targeted phototheranostics of gram-negative bacterial infection.
Bioorg Chem
; 145: 107203, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38377817
3.
DUCNP@Mn-MOF/FOE as a Highly Selective and Bioavailable Drug Delivery System for Synergistic Combination Cancer Therapy.
Nano Lett
; 23(3): 863-871, 2023 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36651872
4.
Photoswitchable PROTACs for Reversible and Spatiotemporal Regulation of NAMPT and NAD.
Angew Chem Int Ed Engl
; 63(12): e202315997, 2024 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38282119
5.
Unleashing the potential of natural biological peptide Macropin: Hydrocarbon stapling for effective breast cancer treatment.
Bioorg Chem
; 140: 106770, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37604094
6.
Strategies for designing proteolysis targeting chimaeras (PROTACs).
Med Res Rev
; 42(3): 1280-1342, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35001407
7.
Optimization of clofibrate with O-desmethyl anetholtrithione lead to a novel hypolipidemia compound with hepatoprotective effect.
Bioorg Med Chem Lett
; 72: 128844, 2022 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35697180
8.
Hydrocarbon stapling modification of peptide alyteserin-2a: Discovery of novel stapled peptide antitumor agents.
J Pept Sci
; 28(7): e3401, 2022 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-34989078
9.
Efficient synthesis of artificial pharmaceutical solid-phase modules for constructing aptamer-drug conjugates.
Bioorg Chem
; 126: 105919, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35667254
10.
Structural simplification and bioisostere principle lead to Bis-benzodioxole-fibrate derivatives as potential hypolipidemic and hepatoprotective agents.
Bioorg Chem
; 117: 105454, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34740054
11.
Aptamer-PROTAC Conjugates (APCs) for Tumor-Specific Targeting in Breast Cancer.
Angew Chem Int Ed Engl
; 60(43): 23299-23305, 2021 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34240523
12.
Discovery of Nonpeptide, Environmentally Sensitive Fluorescent Probes for Imaging p53-MDM2 Interactions in Living Cell Lines and Tissue Slice.
Anal Chem
; 92(3): 2642-2648, 2020 02 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31918545
13.
Potent Dual BET/HDAC Inhibitors for Efficient Treatment of Pancreatic Cancer.
Angew Chem Int Ed Engl
; 59(8): 3028-3032, 2020 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31943585
14.
Design, synthesis and biological evaluation of novel antitumor spirodihydrothiopyran-oxindole derivatives.
Bioorg Med Chem Lett
; 29(13): 1636-1642, 2019 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31047751
15.
Synthesis of spiro-tetrahydrothiopyran-oxindoles by Michael-aldol cascade reactions: discovery of potential P53-MDM2 inhibitors with good antitumor activity.
Org Biomol Chem
; 16(4): 625-634, 2018 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29302672
16.
Design, synthesis and biological evaluation of novel antitumor spirotetrahydrothiopyran-oxindole derivatives as potent p53-MDM2 inhibitors.
Bioorg Med Chem
; 25(20): 5268-5277, 2017 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28797774
17.
Identification of benzothiophene amides as potent inhibitors of human nicotinamide phosphoribosyltransferase.
Bioorg Med Chem Lett
; 26(3): 765-768, 2016 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26755394
18.
Scaffold hopping of sampangine: discovery of potent antifungal lead compound against Aspergillus fumigatus and Cryptococcus neoformans.
Bioorg Med Chem Lett
; 24(17): 4090-4, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25115626
19.
Drugtamer-PROTAC Conjugation Strategy for Targeted PROTAC Delivery and Synergistic Antitumor Therapy.
Adv Sci (Weinh)
; : e2401623, 2024 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38639391
20.
Smart glypican-3-targeting peptide-chlorin e6 conjugates for targeted photodynamic therapy of hepatocellular carcinoma.
Eur J Med Chem
; 264: 116047, 2024 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38118394