Bifunctional Compounds as Molecular Degraders for Integrin-Facilitated Targeted Protein Degradation.

As effective ways to regulate protein levels, targeted protein degradation technologies have attracted great attention in recent years. Here, we established a novel integrin-facilitated lysosomal degradation (IFLD) strategy to degrade extracellular and cell membrane proteins using bifunctional compounds as molecular degraders. By conjugation of a target protein-binding ligand with an integrin-recognition ligand, the resulting molecular degrader proved to be highly efficient to induce the internalization and subsequent degradation of extracellular or cell membrane proteins in an integrin- and lysosome-dependent manner. As demonstrated in the development of BMS-L1-RGD, which is an efficient programmed death-ligand 1 (PD-L1) degrader validated both in vitro and in vivo, the IFLD strategy expands the toolbox for regulation of secreted and membrane-associated proteins and thus has great potential to be applied in chemical biology and drug discovery.

Engineering high reversibility and fast kinetics of Bi nanoflakes by surface modulation for ultrastable nickel-bismuth batteries.

The exploration of a stable and high-rate anode is of pivotal importance for achieving advanced aqueous rechargeable batteries. Owing to the beneficial properties of high conductivity, suitable negative working voltage, and three-electron redox, bismuth (Bi) is considered as a promising anode material, but it suffers from poor stability. Here, we successfully endow Bi nanoflakes (NFs) with prominent cycling performance by a one-step surface oxidation approach to remarkably boost its reversibility. As a result, the partially oxidized Bi NFs (BiO x ) show an admirable capacity (0.38 mA h cm-2 at 2 mA cm-2), good rate capability and superior long-term stability (almost no capacity decay after 20 000 cycles). Furthermore, a durable aqueous Ni//Bi battery is constructed based on the optimized BiO x anode, which exhibits excellent durability with 96% capacity retention after 5000 cycles. This study could open a new avenue for the rational design of efficient anodes for eco-friendly and reliable aqueous rechargeable batteries.