Detalhe da pesquisa
1.
Discovery of a novel 2-aminopyrazine-3-carboxamide as a potent and selective inhibitor of Activin Receptor-Like Kinase-2 (ALK2) for the treatment of fibrodysplasia ossificans progressiva.
Bioorg Med Chem Lett
; 64: 128667, 2022 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35276359
2.
Development of autotaxin inhibitors: A series of tetrazole cinnamides.
Bioorg Med Chem Lett
; 31: 127663, 2021 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33160025
3.
Development of autotaxin inhibitors: A series of zinc binding triazoles.
Bioorg Med Chem Lett
; 28(13): 2279-2284, 2018 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29798825
4.
Defective epithelial barrier function in asthma.
J Allergy Clin Immunol
; 128(3): 549-56.e1-12, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21752437
5.
Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C.
Cancer Discov
; 12(6): 1500-1517, 2022 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35404998
6.
Selective inhibition of histamine-evoked Ca2+ signals by compartmentalized cAMP in human bronchial airway smooth muscle cells.
Cell Calcium
; 71: 53-64, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29604964
7.
Photoinduced crosslinking of double-helical DNA by psoralen covalently linked to a triple helix-forming oligonucleotide under near-physiological conditions.
Nucleosides Nucleotides Nucleic Acids
; 26(8-9): 1005-9, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-18058526
8.
Combining nucleoside analogues to achieve recognition of oligopurine tracts by triplex-forming oligonucleotides at physiological pH.
FEBS Lett
; 579(29): 6616-20, 2005 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-16293248
9.
Discovery, optimization, and biological evaluation of 5-(2-(trifluoromethyl)phenyl)indazoles as a novel class of transient receptor potential A1 (TRPA1) antagonists.
J Med Chem
; 57(12): 5129-40, 2014 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-24884675
10.
Kinetic studies on the formation of DNA triplexes containing the nucleoside analogue 2'-O-(2-aminoethyl)-5-(3-amino-1-propynyl)uridine.
Org Biomol Chem
; 6(1): 122-9, 2008 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-18075656
11.
Actin limits enhancement of nanoparticle diffusion through cystic fibrosis sputum by mucolytics.
Pulm Pharmacol Ther
; 20(6): 708-17, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17055310
12.
Footprinting: a method for determining the sequence selectivity, affinity and kinetics of DNA-binding ligands.
Methods
; 42(2): 128-40, 2007 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-17472895
13.
Unfractionated heparin reduces the elasticity of sputum from patients with cystic fibrosis.
Am J Physiol Lung Cell Mol Physiol
; 293(5): L1240-9, 2007 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17827252
14.
Triplex staples: DNA double-strand cross-linking at internal and terminal sites using psoralen-containing triplex-forming oligonucleotides.
Bioconjug Chem
; 17(6): 1561-7, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-17105237