Diagnostic Performance of Chest CT for SARS-CoV-2 Infection in Individuals with or without COVID-19 Symptoms.

Background The use of chest CT for coronavirus disease 2019 (COVID-19) diagnosis or triage in health care settings with limited severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) capacity is controversial. COVID-19 Reporting and Data System (CO-RADS) categorization of the level of COVID-19 suspicion might improve diagnostic performance. Purpose To investigate the value of chest CT with CO-RADS classification to screen for asymptomatic SARS-CoV-2 infections and to determine its diagnostic performance in individuals with COVID-19 symptoms during the exponential phase of viral spread. Materials and Methods In this secondary analysis of a prospective trial, from March 2020 to April 2020, parallel SARS-CoV-2 PCR and CT with categorization of COVID-19 suspicion was performed with CO-RADS for individuals with COVID-19 symptoms and control participants without COVID-19 symptoms admitted to the hospital for medical emergencies unrelated to COVID-19. CT with CO-RADS was categorized on a five-point scale from 1 (very low suspicion) to 5 (very high suspicion). Area under the receiver operating curve (AUC) was calculated in symptomatic versus asymptomatic individuals to predict positive SARS-CoV-2 PCR, and likelihood ratios for each CO-RADS score were used for rational selection of diagnostic thresholds. Results A total of 859 individuals (median age, 70 years; interquartile range, 52-81 years; 443 men) with COVID-19 symptoms and 1138 control participants (median age, 68 years; interquartile range, 52-81 years; 588 men) were evaluated. CT with CO-RADS had good diagnostic performance (P < .001) in both symptomatic (AUC, 0.89) and asymptomatic (AUC, 0.70) individuals. In symptomatic individuals (42% PCR positive), CO-RADS 3 or greater detected positive PCR with high sensitivity (89%, 319 of 358) and specificity of 73%. In asymptomatic individuals (5% PCR positive), a CO-RADS score of 3 or greater detected SARS-CoV-2 infection with low sensitivity (45%, 27 of 60) but high specificity (89%). Conclusion CT with Coronavirus Disease 2019 Reporting and Data System (CO-RADS) had good diagnostic performance in symptomatic individuals, supporting its application for triage. Sensitivity in asymptomatic individuals was insufficient to justify its use as a first-line screening approach. Incidental detection of CO-RADS 3 or greater in asymptomatic individuals should trigger testing for respiratory pathogens. © RSNA, 2020 Online supplemental material is available for this article.

Does preoperative chemotherapy ease the surgical procedure for Wilms tumor?

PURPOSE: A conclusion of Société Internationale d'Oncologie Pédiatrique in 2001 after protocol 2, 5, 6, 9 and 93-01 was that "preoperative chemotherapy would make nephrectomy easier and furthermore, metastases may disappear or become resectable and vascular extension may regress and partial nephrectomy may become possible." We changed our strategy from preoperative chemotherapy in select cases only to standard 4 to 6-week preoperative chemotherapy in all. However, it appears dubious whether surgical ease or perioperative complications consistently improved after preoperative chemotherapy. We investigated volume changes after chemotherapy and compared all possible variables at a single center using the same surgical team. MATERIALS AND METHODS: A total of 32 children with Wilms tumor between 1998 and 2007 were included in a retrospective analysis, including 15 without preoperative chemotherapy according to the National Wilms' Tumor Study Group protocol before 2001 and 17 with preoperative chemotherapy according to the Société Internationale d'Oncologie Pédiatrique 2001 protocol. We studied the change in tumor volume using picture archive and communication systems volume measurement after chemotherapy, surgical procedure parameters (child body mass index, length and type of incision, blood loss, operative time, hospital stay, pain medication and complications) and outcome (histology and staging). Statistical analysis was performed using the t, Fisher and chi-square tests. RESULTS: The 2 groups were comparable in gender, age (mean 5.4 and 3.9 years, respectively) and staging at diagnosis. At diagnosis mean +/- SD Wilms tumor volume was 408.93 +/- 387.39 and 454.58 +/- 236.71 cm(3) in the nonchemotherapy and chemotherapy groups, respectively. In the chemotherapy group 12 of 17 tumors decreased a mean of 60.9% +/- 24.6% and 5 of 17 increased 42.8% +/- 31.3%. No analyzed parameters were different in the 2 groups. CONCLUSIONS: Our single center analysis with the same surgical team before and after the preoperative chemotherapy era show that it remains unpredictable whether surgery in a child with Wilms tumor is safer and easier after preoperative chemotherapy.

Mural thrombotic deposits in abdominal aortic endografts are common and do not require additional treatment at short-term and midterm follow-up.

PURPOSE: To assess the incidence and clinical significance of thrombotic, nonocclusive mural deposits in abdominal aortic stent-grafts incidentally found on follow-up computed tomography scans after endovascular aneurysm repair (EVAR). MATERIALS AND METHODS: Between 1998 and 2007, 288 patients underwent EVAR of an infrarenal aortic aneurysm. In the majority of cases, a Zenith stent-graft (n = 187) or Excluder stent-graft (n = 71) was implanted. Clinical and radiologic follow-up was performed prospectively according to the EUROSTAR registry, with mean follow-up periods of 4.69 and 5.05 years, respectively, for the Excluder and Zenith groups. RESULTS: Thrombotic deposits were found in 17% and 33% of patients in the Excluder and Zenith groups, respectively, which represents a significant difference (P = .038). Clinically, no distal atheroembolic events were noted during follow-up, and there was no significant difference in survival between patients with and without thrombotic deposits (P = .80). CONCLUSIONS: Incidentally found thrombotic deposits in abdominal aortic endografts are common and device-specific, with a lower incidence in the Excluder group versus the Zenith group. These thrombotic deposits are clinically silent, do not require additional treatment at short-term and midterm follow-up, and do not affect the overall survival of the treated patients.

Video-assisted mediastinoscopic resection of a large symptomatic bronchogenic cyst.

Bronchogenic cysts are congenital lesions from the primitive foregut, mostly located in the mediastinum. Surgical excision in symptomatic cases is often challenging. Video-assisted mediastinoscopy offers a safe and effective approach with less morbidity and shorter hospital stay compared to open sternotomy or posterolateral thoracotomy. We describe a case of a young female with a large symptomatic cyst located in the superior mediastinum. The cyst was completely removed through a video-assisted cervical mediastinoscopy.