Detalhe da pesquisa
1.
Bone marrow microenvironments that contribute to patient outcomes in newly diagnosed multiple myeloma: A cohort study of patients in the Total Therapy clinical trials.
PLoS Med
; 17(11): e1003323, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33147277
2.
Mycobacterium tuberculosis Transfer RNA Induces IL-12p70 via Synergistic Activation of Pattern Recognition Receptors within a Cell Network.
J Immunol
; 200(9): 3244-3258, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29610140
3.
Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization.
J Immunol
; 197(11): 4413-4424, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27793997
4.
Toll-like Receptor 4 Ligands Down-regulate Fcγ Receptor IIb (FcγRIIb) via MARCH3 Protein-mediated Ubiquitination.
J Biol Chem
; 291(8): 3895-904, 2016 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26694610
5.
Granzyme B expression is enhanced in human monocytes by TLR8 agonists and contributes to antibody-dependent cellular cytotoxicity.
J Immunol
; 194(6): 2786-95, 2015 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25667415
6.
Genetic program activity delineates risk, relapse, and therapy responsiveness in multiple myeloma.
NPJ Precis Oncol
; 5(1): 60, 2021 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34183722
7.
Phase Ib Study of Immune Biomarker Modulation with Neoadjuvant Cetuximab and TLR8 Stimulation in Head and Neck Cancer to Overcome Suppressive Myeloid Signals.
Clin Cancer Res
; 24(1): 62-72, 2018 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29061643
8.
Effect of Adding Motolimod to Standard Combination Chemotherapy and Cetuximab Treatment of Patients With Squamous Cell Carcinoma of the Head and Neck: The Active8 Randomized Clinical Trial.
JAMA Oncol
; 4(11): 1583-1588, 2018 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29931076
9.
Bacterial flagellin is a dominant antigen in Crohn disease.
J Clin Invest
; 113(9): 1296-306, 2004 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15124021
10.
Anti-flagellin (CBir1) phenotypic and genetic Crohn's disease associations.
Inflamm Bowel Dis
; 13(5): 524-30, 2007 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-17260364
11.
Phase Ib Trial of the Toll-like Receptor 8 Agonist, Motolimod (VTX-2337), Combined with Cetuximab in Patients with Recurrent or Metastatic SCCHN.
Clin Cancer Res
; 23(10): 2442-2450, 2017 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27810904
12.
Integrative Development of a TLR8 Agonist for Ovarian Cancer Chemoimmunotherapy.
Clin Cancer Res
; 23(8): 1955-1966, 2017 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27702821
13.
Molecular approaches to the role of the microbiota in inflammatory bowel disease.
Ann N Y Acad Sci
; 1072: 39-51, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-17057189
14.
Immunotherapy for prostate cancer using prostatic acid phosphatase loaded antigen presenting cells.
Urol Oncol
; 24(5): 434-41, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16962496
15.
VTX-1463, a novel TLR-8 agonist, attenuates nasal congestion after ragweed challenge in sensitized beagle dogs.
Immun Inflamm Dis
; 4(1): 45-51, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-27042301
16.
Coordinated Activation of Toll-Like Receptor8 (TLR8) and NLRP3 by the TLR8 Agonist, VTX-2337, Ignites Tumoricidal Natural Killer Cell Activity.
PLoS One
; 11(2): e0148764, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26928328
17.
Taking toll: lipid A mimetics as adjuvants and immunomodulators.
Trends Microbiol
; 10(10 Suppl): S32-7, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-12377566
18.
Late-Stage Cancer Patients Remain Highly Responsive to Immune Activation by the Selective TLR8 Agonist Motolimod (VTX-2337).
Clin Cancer Res
; 21(24): 5445-52, 2015 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26152744
19.
A phase I dose-finding study of the novel Toll-like receptor 8 agonist VTX-2337 in adult subjects with advanced solid tumors or lymphoma.
Clin Cancer Res
; 20(14): 3683-91, 2014 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24807889
20.
The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes.
PLoS One
; 8(3): e58164, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23483986