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2.
Nippon Ganka Gakkai Zasshi ; 111(12): 970-5, 2007 Dec.
Artigo em Japonês | MEDLINE | ID: mdl-18186220

RESUMO

PURPOSE: To report a case of uveitis associated with juvenile idiopathic arthritis that progressed from iritis to panuveitis with disc neovascularization during a clinical trial of etanercept, a tumor necrosis factor a (TNF-alpha) blocker. CASE: A 12-year-old girl with juvenile idiopathic arthritis, which had begun at the age of 1 year 7 months. The patient was enrolled in a clinical trial of etanercept at 11 years of age. The methotrexate which she has been taking was stopped, and prednisolone was decreased gradually from 7 mg. The iritis worsened and progressed to panuveitis with disc neovascularization when the prednisolone dose had been tapered to 2 mg. The uveitis was controlled by treatment with a steroid pulse and a liposteroid. CONCLUSION: When starting etanercept therapy in a patient with juvenile idiopathic arthritis who has uveitis and the antirheumatic drug is stopped and steroid treatment tapered, special care is needed to avoid the exacerbation of uveitis.


Assuntos
Antirreumáticos/efeitos adversos , Artrite Juvenil/tratamento farmacológico , Imunoglobulina G/efeitos adversos , Neovascularização Patológica , Disco Óptico/patologia , Pan-Uveíte/patologia , Criança , Ensaios Clínicos como Assunto , Etanercepte , Feminino , Humanos , Receptores do Fator de Necrose Tumoral
3.
J Med Microbiol ; 52(Pt 6): 527-530, 2003 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-12748274

RESUMO

Most causative organisms of sepsis in immunocompromised patients are the same species as those that colonize their own nasopharynx or intestinal tract. To determine whether the strains recovered from blood originate mainly from patients' own flora, isolates from blood and throat and/or stool were investigated by genomic analyses. Surveillance cultures of throat and stool were taken prospectively from cancer patients being treated with intensive chemotherapy followed by haematopoietic stem-cell transplantation. In those cases of sepsis in which the isolate from blood was the same species as that from the throat and/or stool, the genomic profiles of the isolates were compared by PFGE. Ten cases of blood culture-positive sepsis were documented in six of 14 subjects during a 2 year period; isolates of Pseudomonas aeruginosa, Staphylococcus epidermidis, Enterococcus sp., viridans streptococci and Fusobacterium sp. were recovered from blood. In five of seven cases in which the blood isolate was the same species as that from the throat or stool, the genotypes of the isolates from both sites were identical. In the majority of immunocompromised patients, the causative organisms of bloodstream infections originated mainly from their own flora.


Assuntos
Bacteriemia/microbiologia , Bactérias/genética , Hospedeiro Imunocomprometido , Intestinos/microbiologia , Faringe/microbiologia , Adolescente , Bactérias/classificação , Bactérias/isolamento & purificação , Criança , Pré-Escolar , Eletroforese em Gel de Campo Pulsado , Fezes/microbiologia , Feminino , Genótipo , Humanos , Lactente , Masculino
4.
Pediatr Neonatol ; 55(3): 225-7, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-23597543

RESUMO

Paraurethral cyst is a rare cause of interlabial mass formation in female neonates. Paraurethral cysts are generally asymptomatic, and spontaneous regression is expected. However, the management of paraurethral cysts is a controversial topic. Here, we report the case of a female neonate with a paraurethral cyst that regressed spontaneously on day 3 after birth. Urgent surgical treatment of these cysts is not recommended during the early neonatal period.


Assuntos
Cistos/fisiopatologia , Doenças Uretrais/fisiopatologia , Cistos/diagnóstico , Feminino , Humanos , Recém-Nascido , Remissão Espontânea , Doenças Uretrais/diagnóstico
7.
Pediatr Int ; 44(1): 24-7, 2002 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-11982866

RESUMO

BACKGROUND: Nosocomial infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are one of the most serious problems in pediatric wards. Epidemiological analysis of strains isolated in the ward is essential for infection control. There have been few reports in which a molecular epidemiological study of MRSA was performed in pediatric wards. METHODS: Fifty-six MRSA strains isolated in the pediatric ward of Asahikawa Medical College Hospital between 1995 and 1997 were studied. Fifty-two and four isolates were obtained from 27 patients and from two medical staff members, respectively. Forty-one isolates were regarded as colonizing strains and 15 were causes of infections. Genotypes of the isolates were investigated by pulsed-field gel electrophoresis (PFGE). RESULTS: The PFGE patterns of 56 isolates were classified into nine types: type A, its subtypes, A1 and A2, and types B through to G. Seventeen isolates were type A, 32 were type A1, and one of each type of A2 and B through to G were identified. Fifty of 56 isolates, which were isolated from 24 of 29 cases, belonged to type A or its subtypes. CONCLUSIONS: The predominant strain of MRSA isolates in the pediatric ward was a certain strain that may be originated from the one clone. Cross-infection control therefore is the major procedure in the prevention of MRSA dissemination in the ward.


Assuntos
Infecção Hospitalar/genética , Infecções Estafilocócicas/epidemiologia , Staphylococcus aureus/genética , Adulto , Criança , Eletroforese em Gel de Campo Pulsado , Genótipo , Humanos , Japão , Resistência a Meticilina/genética , Staphylococcus aureus/isolamento & purificação
8.
J Immunol ; 170(9): 4862-8, 2003 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-12707369

RESUMO

Using the recently developed ELISPOT cloning methodology, we obtained cDNA clone S35 coding for the Ag epitope recognized by a murine sarcoma Meth A-specific CTL clone AT-1. Analysis of truncated S35 constructs and overlapping peptides revealed that the peptide epitope was LGAEAIFRL. AT-1 CTL lysed peptide-pulsed CMS8 cells at a nanomolar concentration, and the peptide strongly stimulated IFN-gamma production in AT-1 CTL. Sequence homology indicated that the S35 was derived from a mouse homologue of human retinoic acid-regulated nuclear matrix-associated protein (ramp). The ramp gene consisted of 15 exons. The majority of the ramp mRNA was the transcript normally spliced between exons 14 and 15, but a minor population of mRNA with an extended exon 14 was also present in Meth A cells. The epitope was derived from the newly created open reading frame, which resulted from extension of exon 14 after splicing of the adjacent intronic sequence.


Assuntos
Epitopos de Linfócito T/biossíntese , Epitopos de Linfócito T/genética , Éxons/genética , Metilcolantreno , Sarcoma Experimental/imunologia , Linfócitos T Citotóxicos/imunologia , Sequência de Aminoácidos , Animais , Antígenos de Neoplasias/biossíntese , Antígenos de Neoplasias/genética , Antígenos de Neoplasias/isolamento & purificação , Antígenos de Neoplasias/metabolismo , Sequência de Bases , Proteínas de Transporte/biossíntese , Proteínas de Transporte/genética , Proteínas de Transporte/isolamento & purificação , Proteínas de Transporte/metabolismo , Células Clonais , Clonagem Molecular , Testes Imunológicos de Citotoxicidade , Proteínas de Ligação a DNA/biossíntese , Proteínas de Ligação a DNA/genética , Proteínas de Ligação a DNA/isolamento & purificação , Proteínas de Ligação a DNA/metabolismo , Ensaio de Imunoadsorção Enzimática , Epitopos de Linfócito T/isolamento & purificação , Epitopos de Linfócito T/metabolismo , Éxons/imunologia , Biblioteca Gênica , Humanos , Interferon gama/análise , Camundongos , Camundongos Endogâmicos BALB C , Camundongos Endogâmicos DBA , Dados de Sequência Molecular , Sarcoma Experimental/induzido quimicamente , Fatores de Transcrição
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