Detalhe da pesquisa
1.
A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models.
Nat Chem Biol
; 11(6): 432-7, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25915199
2.
Structure-guided optimization of small molecule c-Abl activators.
J Comput Aided Mol Des
; 28(2): 75-87, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24573412
3.
Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites.
Biochem J
; 436(2): 363-9, 2011 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21410436
4.
Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia.
Nat Cancer
; 2(10): 1002-1017, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34790902
5.
C-terminal region of USP7/HAUSP is critical for deubiquitination activity and contains a second mdm2/p53 binding site.
Arch Biochem Biophys
; 503(2): 207-12, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20816748
6.
Baculovirus production of fully-active phosphoinositide 3-kinase alpha as a p85alpha-p110alpha fusion for X-ray crystallographic analysis with ATP competitive enzyme inhibitors.
Protein Expr Purif
; 73(2): 167-76, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20457255
7.
Biochemical characterization of human prolyl hydroxylase domain protein 2 variants associated with erythrocytosis.
Biochemistry
; 47(43): 11165-7, 2008 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-18834144
8.
A High-Throughput Dose-Response Cellular Thermal Shift Assay for Rapid Screening of Drug Target Engagement in Living Cells, Exemplified Using SMYD3 and IDO1.
SLAS Discov
; 23(1): 34-46, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28957646
9.
Crystal structure of the kinase domain of serum and glucocorticoid-regulated kinase 1 in complex with AMP PNP.
Protein Sci
; 16(12): 2761-9, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17965184
10.
A high-throughput screen measuring ubiquitination of p53 by human mdm2.
J Biomol Screen
; 12(8): 1050-8, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17989425
11.
4-Aryl-1,2,3-triazole: a novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivo.
J Med Chem
; 48(18): 5644-7, 2005 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-16134930
12.
A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC.
Cancer Cell
; 28(1): 57-69, 2015 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26175415
13.
Development of a high-throughput screen to detect inhibitors of TRPS1 sumoylation.
Assay Drug Dev Technol
; 11(5): 308-25, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23772552
14.
Assay development and high-throughput screening of small molecular c-Abl kinase activators.
J Biomol Screen
; 16(1): 53-64, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20938045
15.
Discovery and characterization of a cell-permeable, small-molecule c-Abl kinase activator that binds to the myristoyl binding site.
Chem Biol
; 18(2): 177-86, 2011 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-21338916
16.
A second p53 binding site in the central domain of Mdm2 is essential for p53 ubiquitination.
Biochemistry
; 45(30): 9238-45, 2006 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16866370