Detalhe da pesquisa
1.
Loss of TDP-43 in astrocytes leads to motor deficits by triggering A1-like reactive phenotype and triglial dysfunction.
Proc Natl Acad Sci U S A
; 117(46): 29101-29112, 2020 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33127758
2.
FUS-mediated dysregulation of Sema5a, an autism-related gene, in FUS mice with hippocampus-dependent cognitive deficits.
Hum Mol Genet
; 28(22): 3777-3791, 2019 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31509188
3.
Cell-autonomous requirement of TDP-43, an ALS/FTD signature protein, for oligodendrocyte survival and myelination.
Proc Natl Acad Sci U S A
; 115(46): E10941-E10950, 2018 11 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30373824
4.
C9orf72 intermediate repeats are associated with corticobasal degeneration, increased C9orf72 expression and disruption of autophagy.
Acta Neuropathol
; 138(5): 795-811, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31327044
5.
FUS-dependent microRNA deregulations identify TRIB2 as a druggable target for ALS motor neurons.
iScience
; 26(11): 108152, 2023 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37920668
6.
Cholesterol dyshomeostasis in amyotrophic lateral sclerosis: cause, consequence, or epiphenomenon?
FEBS J
; 289(24): 7688-7709, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34469619
7.
TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells.
Elife
; 102021 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33689679
8.
Dysfunction in nonsense-mediated decay, protein homeostasis, mitochondrial function, and brain connectivity in ALS-FUS mice with cognitive deficits.
Acta Neuropathol Commun
; 9(1): 9, 2021 01 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33407930
9.
TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination.
J Cell Biol
; 220(9)2021 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34347016
10.
The vulnerability of motor and frontal cortex-dependent behaviors in mice expressing ALS-linked mutation in TDP-43.
Neurobiol Aging
; 92: 43-60, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32422502
11.
Deregulated expression of a longevity gene, Klotho, in the C9orf72 deletion mice with impaired synaptic plasticity and adult hippocampal neurogenesis.
Acta Neuropathol Commun
; 8(1): 155, 2020 09 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32887666
12.
Elevated FUS levels by overriding its autoregulation produce gain-of-toxicity properties that disrupt protein and RNA homeostasis.
Autophagy
; 15(9): 1665-1667, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31230528
13.
The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy.
Autophagy
; 15(5): 827-842, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30669939
14.
Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis.
Elife
; 82019 02 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30747709