Detalhe da pesquisa
1.
Brexanolone (SAGE-547 injection) in post-partum depression: a randomised controlled trial.
Lancet
; 390(10093): 480-489, 2017 07 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-28619476
2.
Brexanolone as adjunctive therapy in super-refractory status epilepticus.
Ann Neurol
; 82(3): 342-352, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28779545
3.
Open-label, proof-of-concept study of brexanolone in the treatment of severe postpartum depression.
Hum Psychopharmacol
; 32(2)2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28370307
4.
A phase II, randomized, placebo-controlled, double-blind, multi-dose study of SRT2104, a SIRT1 activator, in subjects with type 2 diabetes.
Br J Clin Pharmacol
; 78(1): 69-77, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24446723
5.
Pharmacological characterization of SAGE-718, a novel positive allosteric modulator of N-methyl-d-aspartate receptors.
Br J Pharmacol
; 181(7): 1028-1050, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-37698384
6.
Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man.
Br J Clin Pharmacol
; 75(1): 186-96, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22616762
7.
Allopregnanolone Concentrations in Breast Milk and Plasma from Healthy Volunteers Receiving Brexanolone Injection, With Population Pharmacokinetic Modeling of Potential Relative Infant Dose.
Clin Pharmacokinet
; 61(9): 1307-1319, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35869362
8.
SAGE-718: A First-in-Class N-Methyl-d-Aspartate Receptor Positive Allosteric Modulator for the Potential Treatment of Cognitive Impairment.
J Med Chem
; 65(13): 9063-9075, 2022 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35785990
9.
SAGE-217, A Novel GABAA Receptor Positive Allosteric Modulator: Clinical Pharmacology and Tolerability in Randomized Phase I Dose-Finding Studies.
Clin Pharmacokinet
; 59(1): 111-120, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31338688
10.
Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABAA receptor positive allosteric modulator.
Neuropharmacology
; 181: 108333, 2020 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32976892
11.
Neuroactive Steroid N-Methyl-d-aspartate Receptor Positive Allosteric Modulators: Synthesis, SAR, and Pharmacological Activity.
J Med Chem
; 62(16): 7526-7542, 2019 08 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-31390523
12.
Cardiometabolic effects of a novel SIRT1 activator, SRT2104, in people with type 2 diabetes mellitus.
Open Heart
; 4(2): e000647, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28912956
13.
Neuroactive Steroids. 2. 3α-Hydroxy-3ß-methyl-21-(4-cyano-1H-pyrazol-1'-yl)-19-nor-5ß-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ-Aminobutyric Acid)A Receptor.
J Med Chem
; 60(18): 7810-7819, 2017 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-28753313
14.
Assessing Colonic Exposure, Safety, and Clinical Activity of SRT2104, a Novel Oral SIRT1 Activator, in Patients with Mild to Moderate Ulcerative Colitis.
Inflamm Bowel Dis
; 22(3): 607-14, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26595549
15.
Effects of the small molecule SIRT1 activator, SRT2104 on arterial stiffness in otherwise healthy cigarette smokers and subjects with type 2 diabetes mellitus.
Open Heart
; 3(1): e000402, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27239324
16.
Mucosal administration of heat shock protein-65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient mice.
Circulation
; 106(13): 1708-15, 2002 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-12270867
17.
Neuroactive Steroids. 1. Positive Allosteric Modulators of the (γ-Aminobutyric Acid)A Receptor: Structure-Activity Relationships of Heterocyclic Substitution at C-21.
J Med Chem
; 58(8): 3500-11, 2015 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25799373
18.
Synthesis and biological evaluation of novel cyclosporin a analogues: potential soft drugs for the treatment of autoimmune diseases.
J Med Chem
; 46(5): 674-6, 2003 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-12593646
19.
Cardiovascular effects of a novel SIRT1 activator, SRT2104, in otherwise healthy cigarette smokers.
J Am Heart Assoc
; 2(3): e000042, 2013 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23770971
20.
Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors.
ACS Med Chem Lett
; 3(9): 705-9, 2012 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900538