Detalhe da pesquisa
1.
Characterization of the c10orf76-PI4KB complex and its necessity for Golgi PI4P levels and enterovirus replication.
EMBO Rep
; 21(2): e48441, 2020 02 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31829496
2.
The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme.
J Biol Chem
; 294(18): 7488-7502, 2019 05 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30890560
3.
A single discrete Rab5-binding site in phosphoinositide 3-kinase ß is required for tumor cell invasion.
J Biol Chem
; 294(12): 4621-4633, 2019 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30659094
4.
Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes.
Elife
; 112022 06 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35708309
5.
Probing Protein-Membrane Interactions and Dynamics Using Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS).
Methods Mol Biol
; 2263: 465-485, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33877613
6.
Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents.
Nat Commun
; 12(1): 5885, 2021 10 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34620873
7.
The middle lipin domain adopts a membrane-binding dimeric protein fold.
Nat Commun
; 12(1): 4718, 2021 08 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34354069
8.
Integrated Structural Modeling of Full-Length LRH-1 Reveals Inter-domain Interactions Contribute to Receptor Structure and Function.
Structure
; 28(7): 830-846.e9, 2020 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32433991
9.
Crystal structure of a lipin/Pah phosphatidic acid phosphatase.
Nat Commun
; 11(1): 1309, 2020 03 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32161260
10.
Publisher Correction: Crystal structure of a lipin/Pah phosphatidic acid phosphatase.
Nat Commun
; 11(1): 1734, 2020 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32242008
11.
(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase.
J Med Chem
; 62(13): 6241-6261, 2019 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31244112
12.
Probing the Architecture, Dynamics, and Inhibition of the PI4KIIIα/TTC7/FAM126 Complex.
J Mol Biol
; 430(18 Pt B): 3129-3142, 2018 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30031006
13.
Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5.
Nat Commun
; 9(1): 3772, 2018 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30217979
14.
Neolymphostin A Is a Covalent Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitor That Employs an Unusual Electrophilic Vinylogous Ester.
J Med Chem
; 61(23): 10463-10472, 2018 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30380865