Detalhe da pesquisa
1.
Robust arterial spin labeling MRI measurement of pharmacologically induced perfusion change in rat kidneys.
NMR Biomed
; 34(9): e4566, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34096123
2.
Preclinical evaluation of [11 C]L-235 as a radioligand for Positron Emission Tomography cathepsin K imaging in bone.
J Labelled Comp Radiopharm
; 64(4): 159-167, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33226657
3.
Application of Pharmacokinetic-Pharmacodynamic Modeling to Inform Translation of In Vitro NaV1.7 Inhibition to In Vivo Pharmacological Response in Non-human Primate.
Pharm Res
; 37(10): 181, 2020 Sep 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32888082
4.
Functional imaging of olfaction by CBV fMRI in monkeys: insight into the role of olfactory bulb in habituation.
Neuroimage
; 106: 364-72, 2015 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25498426
5.
Discovery of [¹¹C]MK-8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitors.
Bioorg Med Chem Lett
; 25(21): 4893-4898, 2015 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26077491
6.
Methyl-substitution of an iminohydantoin spiropiperidine ß-secretase (BACE-1) inhibitor has a profound effect on its potency.
Bioorg Med Chem Lett
; 25(21): 4812-4819, 2015 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26195137
7.
Quantification of the glycine transporter 1 in rhesus monkey brain using [18F]MK-6577 and a model-based input function.
Neuroimage
; 59(3): 2589-99, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21930214
8.
Chronic Collection of Cerebrospinal Fluid from Rhesus Macaques (Macaca mulatta) with Cisterna Magna Ports: Update on Refinements.
Comp Med
; 72(1): 45-49, 2022 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34903315
9.
The PET tracer [11C]MK-6884 quantifies M4 muscarinic receptor in rhesus monkeys and patients with Alzheimer's disease.
Sci Transl Med
; 14(627): eabg3684, 2022 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35020407
10.
Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound.
J Neurosci
; 30(19): 6743-50, 2010 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-20463236
11.
Translational Pharmacokinetic-Pharmacodynamic Modeling of NaV1.7 Inhibitor MK-2075 to Inform Human Efficacious Dose.
Front Pharmacol
; 12: 786078, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-35002718
12.
Nav1.7 target modulation and efficacy can be measured in nonhuman primate assays.
Sci Transl Med
; 13(594)2021 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34011626
13.
PET/CT Imaging of 89Zr-N-sucDf-Pembrolizumab in Healthy Cynomolgus Monkeys.
Mol Imaging Biol
; 23(2): 250-259, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33104972
14.
In Vivo Evaluation and Dosimetry Estimate for a High Affinity Affibody PET Tracer Targeting PD-L1.
Mol Imaging Biol
; 23(2): 241-249, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33098025
15.
Application of an end-to-end biomarker discovery platform to identify target engagement markers in cerebrospinal fluid by high resolution differential mass spectrometry.
J Proteome Res
; 9(3): 1392-401, 2010 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-20095649
16.
Rapid P1 SAR of brain penetrant tertiary carbinamine derived BACE inhibitors.
Bioorg Med Chem Lett
; 20(5): 1779-82, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20122828
17.
Discovery of [11C]MK-6884: A Positron Emission Tomography (PET) Imaging Agent for the Study of M4Muscarinic Receptor Positive Allosteric Modulators (PAMs) in Neurodegenerative Diseases.
J Med Chem
; 63(5): 2411-2425, 2020 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32101422
18.
First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates.
J Pharmacol Exp Ther
; 328(1): 131-40, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18854490
19.
Alpha-hydroxy amides as a novel class of bradykinin B1 selective antagonists.
Bioorg Med Chem Lett
; 18(2): 716-20, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18061443
20.
fMRI study of the role of glutamate NMDA receptor in the olfactory processing in monkeys.
PLoS One
; 13(6): e0198395, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29870538