Detalhe da pesquisa
1.
ATI-1777, a Topical Jak1/3 Inhibitor, May Benefit Atopic Dermatitis without Systemic Drug Exposure: Results from Preclinical Development and Phase 2a Randomized Control Study ATI-1777-AD-201.
JID Innov
; 4(2): 100251, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38299059
2.
Selective Inhibition of the MK2 Pathway: Data From a Phase IIa Randomized Clinical Trial in Rheumatoid Arthritis.
ACR Open Rheumatol
; 5(2): 63-70, 2023 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-36604812
3.
Interleukin-1ß-induced interleukin-6 production in A549 cells is mediated by both phosphatidylinositol 3-kinase and interleukin-1 receptor-associated kinase-4.
Cell Biol Int
; 35(4): 355-8, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21166654
4.
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the MK2 Inhibitor ATI-450 in Healthy Subjects: A Placebo-Controlled, Randomized Phase 1 Study.
Clin Pharmacol
; 13: 123-134, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34140814
5.
Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804.
Biochemistry
; 48(27): 6402-11, 2009 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-19496616
6.
Anti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translation.
J Pharmacol Exp Ther
; 331(3): 882-95, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19720877
7.
SD0006: a potent, selective and orally available inhibitor of p38 kinase.
Pharmacology
; 84(1): 42-60, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19590255
8.
Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals.
J Exp Med
; 215(5): 1315-1325, 2018 05 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29549113
9.
Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.
J Med Chem
; 60(13): 5521-5542, 2017 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28498658