Detalhe da pesquisa
1.
An arrayed genome-wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate-limiting for prion propagation.
EMBO J
; 41(23): e112338, 2022 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36254605
2.
The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.
Nat Immunol
; 15(8): 727-37, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24952505
3.
Mechanism of misfolding of the human prion protein revealed by a pathological mutation.
Proc Natl Acad Sci U S A
; 118(12)2021 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-33731477
4.
Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference.
PLoS Pathog
; 17(10): e1010013, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34705895
5.
The ultrastructure of infectious L-type bovine spongiform encephalopathy prions constrains molecular models.
PLoS Pathog
; 17(6): e1009628, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34061899
6.
Genome-wide transcriptomics identifies an early preclinical signature of prion infection.
PLoS Pathog
; 16(6): e1008653, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32598380
7.
Concordance of cerebrospinal fluid real-time quaking-induced conversion across the European Creutzfeldt-Jakob Disease Surveillance Network.
Eur J Neurol
; 29(8): 2431-2438, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35524506
8.
The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6.
Nature
; 536(7617): 464-8, 2016 08 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-27501152
9.
Isolation of infectious, non-fibrillar and oligomeric prions from a genetic prion disease.
Brain
; 143(5): 1512-1524, 2020 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32303068
10.
A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity.
PLoS Pathog
; 14(10): e1007335, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30273408
11.
Prion pathogenesis is unaltered in a mouse strain with a permeable blood-brain barrier.
PLoS Pathog
; 14(11): e1007424, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30496289
12.
Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity.
PLoS Pathog
; 13(11): e1006733, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-29176838
13.
The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein.
Nature
; 501(7465): 102-6, 2013 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23903654
14.
Modifiers of prion protein biogenesis and recycling identified by a highly parallel endocytosis kinetics assay.
J Biol Chem
; 292(20): 8356-8368, 2017 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28341739
15.
Differential Toxicity of Antibodies to the Prion Protein.
PLoS Pathog
; 12(1): e1005401, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26821311
16.
Absolute Quantification of Amyloid Propagons by Digital Microfluidics.
Anal Chem
; 89(22): 12306-12313, 2017 11 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28972786
17.
Prion infections and anti-PrP antibodies trigger converging neurotoxic pathways.
PLoS Pathog
; 11(2): e1004662, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25710374
18.
Structural plasticity of the cellular prion protein and implications in health and disease.
Proc Natl Acad Sci U S A
; 110(21): 8549-54, 2013 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23650394
19.
Prion transmission prevented by modifying the ß2-α2 loop structure of host PrPC.
J Neurosci
; 34(3): 1022-7, 2014 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24431459
20.
Cellular prion protein conformation and function.
Proc Natl Acad Sci U S A
; 108(42): 17308-13, 2011 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-21987789