Detalhe da pesquisa
1.
Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells.
Cell
; 162(3): 552-63, 2015 Jul 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-26232225
2.
PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.
Cell
; 155(2): 397-409, 2013 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24120138
3.
Lack of Evidence for PKM2 Protein Kinase Activity.
Mol Cell
; 59(5): 850-7, 2015 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-26300261
4.
Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation.
Mol Cell
; 57(1): 95-107, 2015 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25482511
5.
Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth.
EMBO J
; 37(22)2018 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30348863
6.
The redox requirements of proliferating mammalian cells.
J Biol Chem
; 293(20): 7490-7498, 2018 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29339555
7.
Lack of evidence for substrate channeling or flux between wildtype and mutant isocitrate dehydrogenase to produce the oncometabolite 2-hydroxyglutarate.
J Biol Chem
; 293(52): 20051-20061, 2018 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30381394
8.
Pyrimidine homeostasis is accomplished by directed overflow metabolism.
Nature
; 500(7461): 237-41, 2013 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23903661
9.
An RNA Damage Response Network Mediates the Lethality of 5-FU in Clinically Relevant Tumor Types.
bioRxiv
; 2023 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-37162991
10.
mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species.
Nat Metab
; 4(12): 1792-1811, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36536136
11.
Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex.
iScience
; 25(11): 105458, 2022 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36388985
12.
The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth.
Cell Rep
; 39(7): 110824, 2022 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35584673
13.
Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited.
Nat Metab
; 4(6): 711-723, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35739397
14.
Cancer Signaling Drives Cancer Metabolism: AKT and the Warburg Effect.
Cancer Res
; 81(19): 4896-4898, 2021 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34598998
15.
The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals.
Elife
; 102021 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33646118
16.
Differential substrate use in EGF- and oncogenic KRAS-stimulated human mammary epithelial cells.
FEBS J
; 288(19): 5629-5649, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33811729
17.
Cancer-associated mutations in human pyruvate kinase M2 impair enzyme activity.
FEBS Lett
; 594(4): 646-664, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31642061
18.
Author Correction: Cooperative nutrient accumulation sustains growth of mammalian cells.
Sci Rep
; 10(1): 12054, 2020 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32694612
19.
Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer.
Nat Commun
; 10(1): 5604, 2019 12 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31811141
20.
Preparation of Lipid-Stripped Serum for the Study of Lipid Metabolism in Cell Culture.
Bio Protoc
; 8(11): e2876, 2018 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34285990