1.
Bioorg Med Chem Lett
; 24(10): 2247-50, 2014 May 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24736116
RESUMO
By considering published structural information we have designed high throughput biaryl lipophilic acid arrays leveraging facile chemistry to expedite their synthesis. We rapidly identified multiple hits which were of suitable IP agonist potency. These relatively simple and strategically undecorated molecules present an ideal opportunity for optimization towards our target candidate profile.