Detalhe da pesquisa
1.
Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood.
Bioorg Med Chem Lett
; 19(13): 3485-8, 2009 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19464884
2.
Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor alpha (TNF-alpha) production: selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles.
J Med Chem
; 50(19): 4728-45, 2007 Sep 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-17715908
3.
Can teaching hospitals use serial formative OSCEs to improve student performance?
BMC Res Notes
; 9(1): 464, 2016 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27737698
4.
Identification of a novel class of selective Tpl2 kinase inhibitors: 4-Alkylamino-[1,7]naphthyridine-3-carbonitriles.
Bioorg Med Chem
; 15(19): 6425-42, 2007 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17664070
5.
Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood.
J Biol Chem
; 282(46): 33295-33304, 2007 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-17848581
6.
Inhibition of Tpl2 kinase and TNFalpha production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis.
Bioorg Med Chem Lett
; 16(23): 6067-72, 2006 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16973359
7.
Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships.
Bioorg Med Chem Lett
; 15(23): 5288-92, 2005 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16165349
8.
Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity.
J Biol Chem
; 279(50): 52117-23, 2004 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-15466476
9.
The NMR structure of the TRADD death domain, a key protein in the TNF signaling pathway.
J Biomol NMR
; 39(4): 337-42, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17922260
10.
Assignment of 1H, 13C and 15N resonances of the death domain of TRADD.
J Biomol NMR
; 28(4): 407-8, 2004 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-14872135