Integrated optical rotation detection scheme for chip-scale atomic magnetometer empowered by silicon-rich SiNx metalens.

High-performance atomic magnetometers (AMs) rely on the measurement of optical rotation, which requires a set of bulky polarization optics that limit their applications in scenarios where portability and compactness are necessary. In this study, a miniaturized AM is constructed based on a cubic 87Rb vapor cell and monolithic metalens, which provides an integrated scheme to achieve optical rotation detection induced by the circular birefringence of polarized atoms. The designed metalens achieves polarization splitting with deflection angles of ±10∘ and focusing with efficiencies of approximately 30% for orthogonal linear polarizations. The sensitivity of our compact device is ∼30 fT/Hz1/2 with a dynamic range of around ±1.45 nT. We envision that the presented approach paves the way for the chip integration of emerging atomic devices, which are in demand for applications such as biomagnetic imaging and portable atomic gyroscopes.

TRPA1 and TRPV1 contribute to iodine antiseptics-associated pain and allergy.

Iodine antiseptics exhibit superior antimicrobial efficacy and do not cause acquired microbial resistance. However, they are underused in comparison with antibiotics in infection treatments, partly because of their adverse effects such as pain and allergy. The cause of these noxious effects is not fully understood, and no specific molecular targets or mechanisms have been discovered. In this study, we show that iodine antiseptics cause pain and promote allergic contact dermatitis in mouse models, and iodine stimulates a subset of sensory neurons that express TRPA1 and TRPV1 channels. In vivo pharmacological inhibition or genetic ablation of these channels indicates that TRPA1 plays a major role in iodine antiseptics-induced pain and the adjuvant effect of iodine antiseptics on allergic contact dermatitis and that TRPV1 is also involved. We further demonstrate that iodine activates TRPA1 through a redox mechanism but has no direct effects on TRPV1. Our study improves the understanding of the adverse effects of iodine antiseptics and suggests a means to minimize their side effects through local inhibition of TRPA1 and TRPV1 channels.

Effects of Ginkgo leaf tablets on the pharmacokinetics of losartan and its metabolite EXP3174 in rats and its mechanism.

CONTEXT: Ginkgo leaf tablets (GLTs) and losartan are often simultaneously used for the treatment of hypertension in Chinese clinics. However, the herb-drug interaction between GLT and losartan is still unknown. OBJECTIVE: This study investigates the effects of GLT on the pharmacokinetics of losartan and its metabolite EXP3174 in rats and its potential mechanism. MATERIALS AND METHODS: The pharmacokinetic profiles of losartan and EXP3174 of orally administered losartan (10 mg/kg) with or without GLT pretreatment (80 mg/kg/day for 10 days) in Sprague-Dawley rats were determined. In vitro, the effects of GLT on the metabolic stability of losartan were investigated with rat liver microsomes. RESULTS: The Cmax (1.22 ± 0.25 vs 1.85 ± 0.37 µg/mL) and the AUC(0-t) (6.99 ± 1.05 vs 11.94 ± 1.79 mg·h/L) of losartan increased significantly (p < 0.05) with GLT pretreatment, while the Cmax (1.05 ± 0.19 vs 0.72 ± 0.12 µg/mL) of EXP3174 decreased significantly (p < 0.05) compared to the control. The t1/2 of losartan was prolonged significantly from 3.94 ± 0.62 to 4.75 ± 0.52 h (p < 0.05). The metabolic stability of losartan was increased from 37.4 min to 59.6 min with GLT pretreatment. DISCUSSION AND CONCLUSIONS: The results indicate that GLT might increase the plasma concentration of losartan and decrease the concentration of EXP3174 through inhibiting the metabolism of losartan.

Effect of Object on Kinesthetic Motor Imagery in Autism Spectrum Disorder: A Pilot Study Based on Eye-Tracking Methodology.

Introduction: Social disturbance is a significant autism spectrum disorder (ASD) symptom. Action representation, which is a fundamental component of social interaction, can be investigated through kinesthetic motor imagery (KMI). KMI has been commonly studied with the well-developed laterality judgment paradigm, wherein participants are required to discriminate the laterality of a hand rotated by different angles along one or more axes. Here, we investigated the KMI processing in individuals with ASD by hand laterality judgment paradigm with eye-tracking methodology. Methods: The current study included 22 participants with ASD and 22 typical developing (TD) peers matched for age, gender, and intelligence. Participants were asked to judge the laterality of hand-with-tooth brush images. Results: Compared to the TD controls, individuals with ASD performed KMI with lower accuracy and longer response time in both correct and incorrect action conditions. The incorrect action representation had greater effect on KMI for individuals with ASD. Differences in eye-movement patterns were also observed, characterized by individuals with ASD were more focused on the object area while TD peers were more focused on the hand area. Conclusion: Results suggest that while altered KMI performance was observed, the incorrect action representation elicited more engagement of KMI in both groups. The object-centered eye-movement pattern may contribute to the refine of motor simulation intervention for individuals with ASD.

Fatalism and depressive symptoms among Chinese college students: Mediation models of locus of control and positive coping.

Fatalistic voluntarism and classic fatalism have opposite effects on depression. This study attempted to measure fatalistic voluntarism with the magnanimity of Taoist values and examined the internal mechanism by which classic fatalism and magnanimity influenced depression. A total of 525 Chinese college students effectively completed self-reported questionnaires. Results showed that classic fatalism is positively correlated with depression, and magnanimity is negatively correlated with depression. Furthermore, classic fatalism and magnanimity can influence depression in Chinese college students through serial mediation by locus of control and positive coping. These findings illuminate the mediating role of locus of control and positive coping, providing specific ways to use two different belief systems, which can help reduce depressive symptoms among college students. In addition, our study may provide some ideas for the development of local culture in the promotion of mental health in different regions.

Childhood emotional abuse and depression symptoms among Chinese adolescents: The sequential masking effect of ruminative thinking and deliberate rumination.

BACKGROUND: This study delves into the relationship between childhood trauma and adolescent depression symptoms, specifically examining the distinct roles of ruminative thinking and deliberate rumination in mediating this connection. The focus is on exploring whether these cognitive processes, namely ruminative thinking and deliberate rumination, operate differently and sequentially in mediating the impact of childhood emotional abuse (CEA) on the development of depression symptoms among Chinese adolescents. METHODS: The study involved gathering data from 489 adolescents, with a relatively balanced gender distribution (44.79 % males and 55.21 % females). The average age of the participants was 16.92 years, with a standard deviation of 0.67. Data collection took place in two Chinese high schools, and participants were tasked with completing assessments related to CEA, ruminative thinking, deliberate rumination, and depression symptoms. The interplay among these variables was then examined using a serial mediation model. RESULTS: The findings of the study indicate that CEA not only exhibited a direct association with adolescent depression symptoms but also exerted indirect effects through distinct mediating mechanisms involving ruminative thinking and deliberate rumination. Specifically, ruminative thinking was identified as a mediator, whereas deliberate rumination emerged as a buffer in the relationship between CEA and depression. Additionally, ruminative thinking and deliberate rumination partially masked the effect of CEA on adolescent depression symptoms in a sequential pattern. CONCLUSIONS: Regarding the link from CEA to adolescent depression symptoms, ruminative thinking is an adverse mediator while deliberate rumination appears to play a benign role. Consequently, the promotion of a shift from ruminative thinking to deliberate rumination is proposed as a promising strategy for alleviating the detrimental effects of CEA on adolescent depression.

Metasurface-integrated elliptically polarized laser-pumped SERF magnetometers.

The emergence of biomagnetism imaging has led to the development of ultrasensitive and compact spin-exchange relaxation-free (SERF) atomic magnetometers that promise high-resolution magnetocardiography (MCG) and magnetoencephalography (MEG). However, conventional optical components are not compatible with nanofabrication processes that enable the integration of atomic magnetometers on chips, especially for elliptically polarized laser-pumped SERF magnetometers with bulky optical systems. In this study, an elliptical-polarization pumping beam (at 795 nm) is achieved through a single-piece metasurface, which results in an SERF magnetometer with a high sensitivity reaching 10.61 fT/Hz1/2 by utilizing a 87Rb vapor cell with a 3 mm inner diameter. To achieve the optimum theoretical polarization, our design combines a computer-assisted optimization algorithm with an emerging metasurface design process. The metasurface is fabricated with 550 nm thick silicon-rich silicon nitride on a 2 × 2 cm 2 SiO2 substrate and features a 22.17° ellipticity angle (a deviation from the target polarization of less than 2%) and more than 80% transmittance. This study provides a feasible approach for on-chip polarization control of future all-integrated atomic magnetometers, which will further pave the way for high-resolution biomagnetism imaging and portable atomic sensing applications.

Effects of dietary Allium mongolicum Regel powder supplementation on the growth performance, meat quality, antioxidant capacity and muscle fibre characteristics of fattening Angus calves under heat stress conditions.

The aim of this study was to investigate the effects of dietary Allium mongolicum Regel powder (AMRP) supplementation on the growth performance, meat quality, antioxidant capacity and muscle fibre characteristics of fattening Angus calves. Growth performance data and longissimus thoracis (LT) samples were collected from four groups of fattening Angus, which were fed either a basal diet (CON) or a basal diet supplemented with an AMRP dose of 10 (LAMR), 15 (MAMR), or 20 g/animal/day AMRP (HAMR) for 120 days before slaughter. AMRP addition to the feed improved growth performance and meat quality and altered muscle fibre type. Some responses to AMRP supplementation were dose dependent, whereas others were not. Together, the results of this study demonstrated that dietary supplementation with 10 g/animal/day AMRP was the optimal dose in terms of fattening calf growth performance, while 20 g/animal/day AMRP supplementation was the optimal dose in terms of meat quality.

Relatively Inefficient Integration of Metaphorical Semantics in Autistic Adults Without Intellectual Impairment.

Individuals diagnosed with autism are often thought to face challenges in comprehensive metaphors, even for the individuals without intellectual impairment. This study is to investigate the features and mechanisms of metaphor integration in the process of metaphor comprehension in real-time and context-free situations in autism, as well as the influence of the mental complexity of metaphor. Twenty autistic adults and twenty typically developing peers carried out a Lexical Decision Task and a Recognition Task. The results of the study showed that, there are deficiencies in real-time metaphor comprehension in autistic adults without intellectual impairment. It may caused by their relatively inefficient integration of metaphor semantics. This mechanism was equally pronounced in the metaphors with different mental complexity.

Depression and bedtime procrastination: Chain mediation of brooding and perceived stress.

This study aimed to investigate the relationships between depression and bedtime procrastination (BP), and the mediating effect of the brooding and perceived stress (PS). Based on the self-regulatory failure theory of procrastination in a temporal context and response styles theory, we constructed a chain mediation model. Total of 1136 participants (389 males and 747 females) completed the online questionnaire. In the present study, the participants were asked to fill The Beck Depression Inventory-II (BDI-II), Bedtime Procrastination Scale (BPS), Perceived Stress Scale (PSS) and Ruminative Responses Scale (RRS). The results showed that high level of depression positively affected brooding, and high level of brooding further positively affected PS, thus leading to BP. However, we did not find the mediating effect of brooding between depression and BP. This indicated that mood plays an important role in the mechanism of depression's effect on BP. The findings revealed pathways between depression and BP and was of great significance for the intervention of BP.

Impact of Social Support on Depressive Symptoms among Postgraduates during the Coronavirus Disease 2019 Pandemic: A Moderated Mediation Analysis.

The coronavirus disease (COVID-19) pandemic continues to spread worldwide, and its related stressors are causing a high prevalence of mental health problems among graduate students. This has the potential for long-term effects on their mental well-being. However, few large-scale studies have been conducted on multiple risk and protective factors. Therefore, we aimed to test the impact of social support on depressive symptoms among graduate students and analyze the mediating role of positive coping and the regulatory role of neuroticism. From 1-8 October 2021, 1812 Chinese graduate students were surveyed online. We used a structural equation model to study the mediating role of positive coping in the relationship between social support and depressive symptoms and used the Hayes PROCESS macro to conduct mediating analysis. The incidence of depressive symptoms was 10.40%. These results showed that positive coping influenced the social support's influence on depression symptoms to some extent. Moreover, neuroticism regulates the indirect relationship between social support and depressive symptoms through active coping. Further research is needed to assess the impact of various forms of social support on graduate students' mental health and to develop strategies for maintaining their well-being, such as network mindfulness.

Influence of Childhood Psychological Maltreatment on Peer Attachment Among Chinese Adolescents: The Mediation Effects of Emotion Regulation Strategies.

The formation of peer attachment is vitally important for the mental health of adolescents. Additionally, converging evidences show that childhood emotional trauma leads to poor peer attachment during adolescence. However, little is known about the underlying mechanism accounting for the link between early emotional trauma and adolescent peer attachment. Therefore, the present study is intended to examine the relationship between childhood psychological maltreatment (CPM) and peer attachment among Chinese adolescents and reveal its underlying mechanism. In total, we collected data from 670 adolescents (36.5% males and 63.5% females, Mage = 16.44 years, SD = 0.78) attending two Chinese high schools. These participants completed measurement scales for CPM (emotional abuse and neglect), peer attachment, and emotion regulation strategies, including cognitive reappraisal (CR) and expressive suppression (ES). The multiple mediation models showed that emotional neglect negatively predicted adolescent peer attachment but that emotional abuse did not. Furthermore, the two emotion regulation strategies, CR and ES, completely mediated the relationship between emotional abuse and peer attachment and partially mediated the relationship between emotional neglect and peer attachment. These findings extend the existing studies on adolescent peer attachment and elucidate how childhood emotional trauma negatively influences adolescent peer attachment. In addition, the present results provide implications for improving the peer attachment of adolescents. On one hand, appropriate family intervention should be implemented to reduce CPM. On the other hand, schools can focus on improving the peer attachment of adolescents by enhancing their emotion regulation. Specifically, adolescents should be taught how to use adaptive strategies, such as CR, to regulate negative emotions.

Topical borneol relieves nonhistaminergic pruritus via targeting TRPA1 and TRPM8 channels in peripheral nerve terminals of mice.

Borneol has been used successfully for the treatment of itchy skin in traditional Chinese medicine. However, the antipruritic effect of borneol has rarely been studied, and the mechanism is unclear. Here, we showed that topical application of borneol on skin substantially suppressed pruritogen chloroquine- and compound 48/80-induced itching in mice. The potential targets of borneol, including transient receptor potential cation channel subfamily V member 3 (TRPV3), transient receptor potential cation channel subfamily A member 1 (TRPA1), transient receptor potential cation channel subfamily M member 8 (TRPM8), and gamma-aminobutyric acid type A (GABAA) receptor were pharmacologically inhibited or genetically knocked out one by one in mouse. Itching behavior studies demonstrated that the antipruritic effect of borneol is largely independent of TRPV3 and GABAA receptor, and TRPA1 and TRPM8 channels are responsible for a major portion of the effect of borneol on chloroquine-induced nonhistaminergic itching. Borneol activates TRPM8 and inhibits TRPA1 in sensory neurons of mice. Topical co-application of TRPA1 antagonist and TRPM8 agonist mimicked the effect of borneol on chloroquine-induced itching. Intrathecal injection of a group II metabotropic glutamate receptor antagonist partially attenuated the effect of borneol and completely abolished the effect of TRPM8 agonist on chloroquine-induced itching, suggesting that a spinal glutamatergic mechanism is involved. In contrast, the effect of borneol on compound 48/80-induced histaminergic itching occurs through TRPA1-and TRPM8-independent mechanisms. Our work demonstrates that borneol is an effective topical itch reliever, and TRPA1 inhibition and TRPM8 activation in peripheral nerve terminals account for its antipruritic effect.

[Effect of Manure Application on the Adsorption of Antibiotics to Soil].

Sulfonamide antibiotics and florfenicol(FFC) are commonly used antibiotics in Zhejiang Province. They have weak adsorption on soil and are easy to migrate, with high environmental risks. In recent years, most of the studies on the potential risk of fecal-derived antibiotics to farmland soil were conducted by adding manure under laboratory conditions; therefore, it is impossible to assess the risk of antibiotic pollution under natural fertilization. Therefore, batch balance experiments were conducted to explore the effects of different soil types and manure types on the adsorption of antibiotics in the soil, in which five types of dryland farmland soils[Lin'an(LA), Jiashan(JS), Longyou(LY), Kaihua(KH), and Jinhua(JH)]in Zhejiang Province that have been used with different fertilizers(chicken manure, pig manure, and chemical fertilizer) for a long time were chosen, and four types of commonly used antibiotics[sulfadiazine(SD), sulfamethazine(SMT), sulfamethoxazole(SMZ), and FFC]were selected. The results showed that the adsorption of the four antibiotics in the experimental soil was weak, and the adsorption capacity decreased in the order of:SMT(1.44-13.23 mg1-(1/n)·L1/n·kg-1)>SMZ(0.73-6.05 mg1-(1/n)·L1/n·kg-1)>SD(0.16-5.57 mg1-(1/n)·L1/n·kg-1)>FFC(0.27-3.81 mg1-(1/n)·L1/n·kg-1). The Freundlich model was superior to the linear model in fitting the isotherm adsorption of SD, SMT, and FFC, in which SD and FFC belonged to "S" type adsorption, and SMT belonged to "L" type adsorption. For SMZ, the fitting effect of the linear model was better than that of the Freundlich model. The contents of total organic carbon(TOC) and dissolved organic carbon(DOC) could better predict the adsorption capacity of the four antibiotics(r=0.548-0.808), and the values of cation exchange capacity(CEC) and electrical conductivity(EC) could better predict the adsorption capacity of SMT and FFC(r=0.758-0.841). Compared with the application of chemical fertilizer, manure application increased the values of TOC, DOC, CEC, and EC in acidic and neutral soils, which was conducive to the adsorption of antibiotics on the soil. Meanwhile, manure application also increased pH in acidic and neutral soils, which was not conducive to the adsorption of antibiotics on the soil. In addition, manure application reduced the values of TOC, DOC, CEC, EC, and pH in alkaline soils. The lower pH was conducive to antibiotic adsorption on the soil, whereas the lower content of the other four was not conducive to antibiotic adsorption on the soil. For the acidic soil with low fertility, the application of manure increased soil fertility and thus increased the adsorption of antibiotics on the soil, such as the LA soil with chicken manure, the LY(1) soil with pig manure, and the JH soil with chicken manure and pig manure. However, for the acidic and neutral soils with high fertility, the application of manure had significantly increased soil pH and thus reduced the adsorption of antibiotics on the soil, such as the JS soil with chicken manure and pig manure and the LY(2) soil with chicken manure. For calcareous soil with high fertility and pH(such as KH soil), the adsorption profiles of the four types of antibiotics on the soil showed diversity after the application of manure:the adsorption capacity of SD increased significantly after the application of chicken manure and pig manure, whereas the adsorption capacity of SMT and SMZ decreased significantly, and the adsorption capacity of FFC declined significantly after the application of chicken manure. Therefore, manure application according to soil fertility could effectively control the environmental risk of fecal antibiotics.

Extraversion and Neuroticism on College Freshmen's Depressive Symptoms During the COVID-19 Pandemic: The Mediating Role of Social Support.

Objective: This study aims to explore the direct effects of extraversion and neuroticism on college freshmen's depressive symptoms and their indirect effects via social support under the background of COVID-19. Method: A total of 3,563 college freshmen were surveyed using the extraversion and neuroticism scales of the Chinese version of the Eysenck Personality Questionnaire (EPQ), the Chinese version of the Beck Depression Inventory-II (BDI-II), and the Social Support Rating Scale (SSRS). Partial correlation analyses and regression analyses were used. Results: (1) Extraversion had a significant and negative predictive effect on depressive symptoms, while neuroticism positively predicted depressive symptoms. The interaction effect between extraversion and neuroticism on depressive symptoms was also significant. Neuroticism had a greater impact on depressive symptoms in college freshmen with low levels of extraversion. (2) Furthermore, social support partially mediated the relationships between extraversion and depressive symptoms, and neuroticism and depressive symptoms. Conclusions: Extraversion and neuroticism can directly affect college freshmen' s depressive symptoms, and have indirect effects via the mediating role of social support. Additionally, extraversion interacts with neuroticism, and extraversion plays a protective role in the effect of neuroticism on depressive symptoms. These findings help identify college freshmen at high risk of depression and design effective prevention or intervention measures for them.

Post-traumatic Growth and Psychological Resilience During the COVID-19 Pandemic: A Serial Mediation Model.

Although the World Health Organization (WHO) has issued guidelines for managing to contain, mitigate, and limit of the COVID-19. However, it is more essential to highlight the urgency and importance of evaluating social functioning and mental health status during the pandemic. College students have experienced serious problems and have had to overcome many negative situations brought about by the pandemic. Accordingly, the present study intended to use Chinese college students as sample to examine the positive adoption and changes during the ongoing COVID-19. Guided by literatures in this filed, we explored the internal mechanism of post-traumatic growth affecting psychological resilience, and considered about mediation roles of positive coping styles and cognitive reappraisal. A total of 463 college students from universities in China effectively completed online questionnaires. The result indicated that these four variables were positively correlated with each other (ps < 0.001). More importantly, our findings proved a direct and positive effect on psychological resilience. Positive coping styles and cognitive reappraisal, respectively, mediated the relationship between post-traumatic growth and psychological resilience. Over all, the hypothesized serial model conclusively fits the data: students with high-level post-traumatic growth tended to report increased use of positive coping strategies, which further facilitated their cognitive reappraisal, and subsequently, promoted their psychological resilience. The findings obtained in this study will provide a theoretical basis and possible viable strategies for both targeted crisis intervention and psychological trauma recovery plans.

Social Support and Depressive Symptoms Among Adolescents During the COVID-19 Pandemic: The Mediating Roles of Loneliness and Meaning in Life.

Identifying which factors influence depressive symptom during the COVID-19 pandemic is highly significant for psychological crisis interventions among adolescents. Social support is likely to be one of the main factors. However, the underlying mechanism is still not well understood in the context of COVID-19. The current study examines whether loneliness and meaning in life mediate the association between social support and depressive symptoms in adolescents. A sample of 1,317 high school students in China were surveyed using the Perceived Social Support Scale, the Chinese Child Loneliness Scale, the Meaning in Life Questionnaire, and the Beck Depression Inventory-II. The results showed that social support predicted depressive symptoms directly and indirectly by enhancing loneliness and diminishing the sense of meaning in life. These findings help in providing new entry points in the design of effective depression prevention and intervention for adolescents during the COVID-19 pandemic.

New Models for Estimating the Sorption of Sulfonamide and Tetracycline Antibiotics in Soils.

Sulfonamides (SAs) and tetracyclines (TCs) are two classes of widely used antibiotics. There is a lack of easy models for estimating the parameters of antibiotic sorption in soils. In this work, a dataset of affinity coefficients (Kf and Kd) of seven SA/TC antibiotics (i.e., sulfachlorpyridazine, sulfamethazine, sulfadiazine, sulfamethoxazole, oxytetracycline, tetracycline, and chlortetracycline) and associated soil properties was generated. Correlation analysis of these data showed that the affinity coefficients of the SAs were predominantly affected by soil organic matter and cation exchange capacity, while those of the TCs were largely affected by soil organic matter and pH. Pedotransfer functions for estimating Kf and Kd were built by multiple linear regression analysis and were satisfactorily validated. Their performances would be better for soils having higher organic matter content and lower pH. These pedotransfer functions can be used to aid environmental risk assessment, prioritization of antibiotics and identification of vulnerable soils.

Psychological maltreatment and depression symptoms among Chinese adolescents: A multiple mediation model.

BACKGROUND: Adolescents are at risk of depression, and recent studies also found a high prevalence of depression among Chinese adolescents. Therefore, it is necessary to explore the risk and protective factors of depression among Chinese adolescents. OBJECTIVE: This study examined the direct effect of psychological maltreatment on depression symptoms in adolescents and the mediating roles of emotion regulation and social support in their relationship. METHOD: Data were collected from Chinese senior high school students (N = 687, 36.5 % males and 63.5 % females, Mage = 16.44 years, SD = 0.78) who completed the measures of psychological maltreatment, depression symptoms, perceived social support, and emotion regulation strategies, including cognitive reappraisal and expressive suppression. RESULTS: The results indicated that: (a) psychological maltreatment was positively correlated with depression symptoms; (b) the two emotion regulation strategies and perceived social support partially mediated the link between psychological maltreatment and depression symptoms separately; (c) the two emotion regulation strategies and perceived social support partially mediated the link between psychological maltreatment and depression symptoms in a sequential pattern. CONCLUSION: Psychological maltreatment was positively associated with depression symptoms in adolescents. Emotion regulation and perceived social support both significantly mediated the relationship between psychological maltreatment and depression symptoms.

Atypical processing pattern of gaze cues in dynamic situations in autism spectrum disorders.

Psychological studies have generally shown that individuals with Autism Spectrum Disorder (ASD) have particularity in the processing of social information by using static or abstract images. Yet, a recent study showed that there was no difference in their use of social or non-social cues in dynamic interactive situations. To establish the cause of the inconsistent results, we added gaze cues in different directions to the chase detection paradigm to explore whether they would affect the performance of participants with ASD. Meanwhile, eye-tracking methodology was used to investigate whether the processing patterns of gaze cues were different between individuals with ASD and TD. In this study, unlike typical controls, participants with ASD showed no detection advantage when the direction of gaze was consistent with the direction of movement (oriented condition). The results suggested that individuals with ASD may utilize an atypical processing pattern, which makes it difficult for them to use social information contained in oriented gaze cues in dynamic interactive situations.