Development of chlorine dioxide sustained-release device using carboxymethyl cellulose-polyvinyl alcohol-ß-cyclodextrin ternary hydrogel and a new sustained-release kinetic model.

Owing to unique physiochemical and biological properties as well as the ability to be combined with a wide variety of materials for both biocompatibility and hydrophilia, carboxymethyl cellulose (CMC) is an excellent choice as a carrier. Loading Chlorine dioxide (ClO2) into biodegradable carrier for its good disinfection performance and high safety factors has attracted significantattention. Therefore, in this study, we used ClO2 as a model drug, and a sustained-ClO2-gas-release gel was developed from degradable materials, such as carboxymethyl cellulose (CMC), polyvinyl alcohol (PVA), and ß-cyclodextrin (ßCD), through a simple and benign crosslinking strategy. Notably, the gel had sustained-release property in a wide temperature range of 4-35 â„ƒ and released ClO2 gas effectively for more than 30 days. Furthermore, a loss factor was proposed based on the incomplete release of the drug in the sustained release process to a chieve a good fit with the gas diffusion process. A new diffusion model was designed based on the Korsmeyer-Peppas model, and an excellent fit was obtained. This sustained-ClO2-gas-release gel provides theoretical and technical guidance for the development of sustained-disinfectant-release agents for use in space and offers new insights into the sustained release model of skeleton-soluble hydrogels. Supplementary Information: The online version contains supplementary material available at 10.1007/s10570-023-05070-6.

Performance of Polydopamine Complex and Mechanisms in Wound Healing.

Polydopamine (PDA) has been gradually applied in wound healing of various types in the last three years. Due to its rich phenol groups and unique structure, it can be combined with a variety of materials to form wound dressings that can be used for chronic infection, tissue repair in vivo and serious wound healing. PDA complex has excellent mechanical properties and self-healing properties, and it is a stable material that can be used for a long period of time. Unlike other dressings, PDA complexes can achieve both photothermal therapy and electro activity. In this paper, wound healing is divided into four stages: antibacterial, anti-inflammatory, cell adhesion and proliferation, and re-epithelialization. Photothermal therapy can improve the bacteriostatic rate and remove reactive oxygen species to inhibit inflammation. Electrical signals can stimulate cell proliferation and directional migration. With low reactive oxygen species (ROS) levels, inflammatory factors are down-regulated and growth factors are up-regulated, forming regular collagen fibers and accelerating wound healing. Finally, five potential development directions are proposed, including increasing drug loading capacity, optimization of drug delivery platforms, improvement of photothermal conversion efficiency, intelligent electroactive materials and combined 3D printing.

Antibacterial Mechanism of Curcumin: A Review.

Curcumin is a plant-derived polyphenolic active substance with broad-spectrum antibacterial properties. Curcumin blocks bacterial growth owing to its structural characteristics and the generation of antioxidation products. Curcumin can inhibit bacterial virulence factors, inhibit bacterial biofilm formation and prevent bacterial adhesion to host receptors through the bacterial quorum sensing regulation system. As a photosensitizer, curcumin acts under blue light irradiation to induce phototoxicity and inhibit bacterial growth. Moreover, it can exert a synergistic antibacterial effect with other antibacterial substances. In this review, we summarize the research progress on the antibacterial mechanism of curcumin based on five targeting structures and two modes of action. Our discussion provides a theoretical basis and technical foundation for the development and application of natural antibacterial agents.

Preparation and characterization of ß-cyclodextrin-oregano essential oil microcapsule and its effect on storage behavior of purple yam.

BACKGROUND: Natural plant essential oils have antimicrobial properties; however, essential oils are difficult to maintain in a system because of their volatile nature. First, we prepared microcapsules from ß-cyclodextrin and oregano essential oil and characterized their properties. Second, the effect of microcapsules on the preservation of freshly cut purple yam was studied using an edible coating technique. Purple yams immersed in distilled water were used as control, and their characteristics were compared with yams coated with citric acid, citric acid + sodium alginate, and citric acid + sodium alginate + ß-cyclodextrin-oregano essential oil microcapsules (CA-SA-MC) and stored at 4 °C for 5 days. RESULTS: Microcapsules of oregano essential oil and ß-cyclodextrin solution were successfully prepared via the inclusion method, with an optimal encapsulation efficiency of 55.14%. Scanning electron microscopy, Fourier transform infrared spectroscopy, and thermogravimetric analysis showed strong bonds between ß-cyclodextrin and oregano essential oil. All edible coatings, particularly CA-SA-MC, significantly (P ≤ 0.05) maintained firmness, total soluble solids, ascorbic acid content, and anthocyanin content compared with control treatment. This treatment also prevented browning and extended the shelf life of purple yam. CONCLUSION: Oregano essential oil can be successfully encapsulated into cyclodextrin microcapsules. It has a great impact on the shelf life extension of purple yam and could be successfully applied to other fresh produce. © 2020 Society of Chemical Industry.

Application of chlorine dioxide microcapsule sustained-release antibacterial films for preservation of mangos.

In this study, fresh mangos were packed using a custom-made antimicrobial film coated with sustained-release chlorine dioxide microcapsules. We then compared physical and chemical indexes, such as weight loss rate, firmness, chromatic aberrations, soluble solids, vitamin C, titratable acid, and other nutritional indicators, to examine changes in the mango and film during storage. Our findings revealed that control mango showed loss of edible value and commercial value after 21 days of storage, and the chlorine dioxide microcapsule antibacterial film group still retains food value and commercial value. Cross-sectional scanning electron microscopy images of the used film showed that the polylactic acid film was smooth and flat, whereas cross-sections of the antimicrobial film showed that the film was covered with voids due to deliberate release of chlorine dioxide gas during the packaging process. Thus, the antibacterial film exhibited erosion and degradation. These findings provided important insights into the use of antimicrobial films for the packaging of fruits during storage, which is essential for promoting the application of solid chlorine dioxide antimicrobial film in packaging preservation.

Dissolution behavior of ionic liquids for different ratios of lignin and cellulose in the preparation of nanocellulose/lignin blends.

Lignin is regarded as a potential solution for boosting the strength of cellulose-based products. However, the mechanism of co-solubilization for lignin and cellulose has not been investigated. In this study, the effect of lignin content on the interaction between lignin and nanocellulose during lignin/cellulose co-dissolution was examined. The results revealed that lignin binds to nanocellulose throughout the dissolution process to limit the degradation of cellulose and to prepare nanocellulose/lignin composites. Moreover, the S units in lignin were more likely to interact with cellulose during the dissolution process, whereas the G units were more likely to condense. However, when the lignin content exceeded 30 wt%, the excess lignin created a severe condensation reaction, which led to a decrease in the lignin content bound to cellulose, resulting in an unequal dissolution of cellulose. Thus, a small amount of lignin attached to cellulose during the co-dissolution of lignin and cellulose inhibits cellulose degradation and can be utilized to create nanocellulose/lignin to extend the potential applications of nanocellulosic materials.

Preparation and application of chlorine dioxide gas slow-release fresh-keeping card based on polylactic acid.

Blueberries are highly perishable after harvest, so a simple preservation method is needed to extend the shelf life of blueberries. In this study, sodium chlorite-loaded sepiolite was added to polylactide solution with tartaric acid to create a ClO2 gas slow-release fresh-keeping card. The fresh-keeping card absorbs moisture in the air, which causes tartaric acid to enter the sepiolite and react with sodium chlorite to release ClO2 gas slowly. The study investigated the impact of fresh-keeping cards on the quality attributes of blueberries, including appearance, decay rate, ethylene release rate, respiration rate, hardness, ascorbic acid content, and anthocyanin concentration. Low-field nuclear magnetic technology was used to analyze the water state and distribution of blueberries during storage. The results showed that the ClO2 gas released by the fresh-keeping card can destroy ethylene in the air and kill microorganisms in blueberries, thereby delaying fruit decay.

Sodium carboxymethyl cellulose hydrogels containing montmorillonite-NaClO2 for postharvest preservation of Chinese bayberries.

Owing to their lack of outer skin, Chinese bayberries are highly susceptible to mechanical damage during picking, which accelerates bacterial invasion and rotting, shortening their shelf life. In this study, montmorillonite (MMT) was used to absorb an aqueous sodium chlorite solution embedded in a carboxymethyl cellulose sodium hydrogel after freeze drying, and the hydrogel was crosslinked by Al3+ ions. Al3+ hydrolyzed to produce H+, creating an acidic environment within the hydrogel and reacting with NaClO2 to slowly release ClO2. We prepared a ClO2 slow-release hydrogel gasket with 0.5 wt% MMT-NaClO2 and investigated its storage effect on postharvest Chinese bayberries. Its inhibition rates against Escherichia coli and Listeria monocytogenes were 98.84% and 98.96%, respectively. The results showed that the gasket preserved the appearance and nutritional properties of the berries. The antibacterial hydrogel reduced hardness loss by 26.57% and ascorbic acid loss by 46.36%. This new storage method could also be applicable to other fruits and vegetables.

Failure Mechanism of the Corrugated Medium under Simulated Cold Chain Logistics.

It is necessary to develop corrugated medium food packaging, which is suitable for highly humid environments, to meet the demands of cold chain logistics. In this paper, we investigated the influence of the transverse ring crush index of different environmental factors of corrugated medium and the failure mechanisms during cold chain transportation. After freeze-thaw treatment of corrugated medium, XRD and DP showed a decrease in crystallinity and polymerization of 3.47 and 7.83%, respectively. Also, the FT-IR spectra of the paper showed that the number of intermolecular hydrogen bonds decreased by about 3.00% after freezing. SEM and XRD showed CaCO3 precipitation on the paper surface and a 26.01% increase in pore size. This study would be beneficial in further expanding the applications of cellulose-based paperboard cold chain transportation.

Preparation and plasticizing mechanism of deep eutectic solvent/lignin plasticized chitosan films.

Chitosan (CS) is a natural biopolymer from crab shells known for its biocompatibility and biodegradability; however, CS films are extremely rigid, limiting their applications. In this study, CS composite films were prepared based on the selective dissolution of lignin by deep eutectic solvents (DES), and the toughening effect of this DES/lignin on a CS film substrate was examined, along with its corresponding mechanism. The addition of DES/lignin effectively increased the plasticity of the CS film, giving a maximum elongation at break of 62.6 % for the plasticized film, which is 12.5 times that of the CS film. Fourier transform infrared spectroscopy and nuclear magnetic resonance analyses showed that molecules in the DES/lignin complex interacted with CS to break the hydrogen bonds between the CS molecules; simultaneously, each molecule recombined with the CS molecules via hydrogen bonding. Thus, the rigidity of the CS molecular chain was weakened to achieve a plasticized CS film, thereby demonstrating the ability of DES/regenerated lignin to improve the toughness of CS films, which provides a reference for modifying plasticity and could lead to the broader utilization of CS films.

Recent Advances in Sustainable Antimicrobial Food Packaging: Insights into Release Mechanisms, Design Strategies, and Applications in the Food Industry.

In response to the issues of foodborne microbial contamination and carbon neutrality goals, sustainable antimicrobial food packaging (SAFP) composed of renewable or biodegradable biopolymer matrices with ecofriendly antimicrobial agents has emerged. SAFP offers longer effectiveness, wider coverage, more controllability, and better environmental performance. Analyzing SAFP information, including the release profile of each antimicrobial agent for each food, the interaction of each biomass matrix with each food, the material size, form, and preparation methods, and its service quality in real foods, is crucial. While encouraging reports exist, a comprehensive review summarizing these developments is lacking. Therefore, this review critically examines recent release-antimicrobial mechanisms, kinetics models, preparation methods, and key regulatory parameters for SAFPs based on slow- or controlled-release theory. Furthermore, it discusses fundamental physicochemical characteristics, effective concentrations, advantages, release approaches, and antimicrobial and preservative effects of various materials in food simulants or actual food. Lastly, inadequacies and future trends are explored, providing practical references to regulate the movement of active substances in different media, reduce the reliance on petrochemical-based materials, and advance food packaging and preservation technologies.

Unveiling the retrogradation mechanism of a novel high amylose content starch-Pouteria campechiana seed.

The research of starch retrogradation have been attracting interest. Thereby, the long-term retrogradation mechanism (0-21 days) of Pouteria campechiana seed starch (PCSS) was investigated. The results showed that crystal type was changed from A- to B + V-type during retrogradation. The retrogradation PCSS (RPCSS) exhibited faster retrogradation rate and more compact internal ultra-structure compared to rice, wheat and maize starch. Pearson correlation indicated that, as retrogradation days increased, values of α-1,4-glycosidic bond, A chains, double helix, V-type polymorphism, Mw, relative crystallinity (Rc) and short-range order gradually significantly increased, and B1 chains, B3 + chains values gradually significantly dropped (p < 0.05). These inferred an increasing peak temperature and compactness of morphology with increasing retrogradation days. Compared to native starch, RPCSS α-1.4-glycosidic bond was increased, which indicated that its quick molecules degradation including decreased Mw, B3 + chains, Rc, semicrystalline order, and ΔH. These might provide a theoretical direction for preparation of starch-basis food.

Effect of the Amylose Nanoscale Polymerization Index on the Digestion Kinetics and Mechanism of Recombinant Chinese Seedless Breadfruit Starch Triadic Complexes.

The demand for multicomponent foods to meet human energy and nutritional needs has been increasing; however, few studies have addressed the theoretical basis for their preparation. We investigated the effect of the nanoscale polymerization index (DPw) of amylose on the logarithm of slope plot-based kinetics and the mechanism of digestion of starch-lauric acid-ß-lactoglobulin protein complexes. Amylose from each of the five Chinese seedless breadfruit species was mixed with breadfruit amylopectin with the highest resistant starch (RS) content to form starch ternary complexes with various amylose DPws. All five complexes exhibited V-type crystalline diffraction and rod-like molecular configuration. Characteristic X-ray diffraction peaks and Fourier transform-infrared spectra of the ternary complexes revealed similar molecular configurations. As the amylose DPw increased, the complexing index, relative crystallinity, short-range order, weight-average molar mass, molecular density index, gelatinization temperature, decomposition temperature, RS, slowly digestible starch (SDS), and speed rate constants at the second hydrolysis stage (k2) increased, whereas the semicrystalline lamellae thickness, mass fractal structure parameter, average characteristic crystallite unit length, radius of gyration, fractal dimension and cavities of granule surface microstructure, final viscosity, interval speed rate from SDS to RS, equilibrium concentration, and glycemic index decreased. The digestion kinetics exhibited highly significant variation according to the physiochemical properties and multiscale supramolecular structure (r > 0.99 or r < -0.99, p < 0.01). Together, these results identify amylose DPw as an important structural factor that markedly affects the kinetics and mechanism of ternary complex digestion and provide a new theoretical direction for the production of starch-based multicomponent foods.

Polyvinyl alcohol film with chlorine dioxide microcapsules can be used for blueberry preservation by slow-release of chlorine dioxide gas.

Introduction: Chlorine dioxide (ClO2) is a safe and efficient bactericide with unique advantages in reducing foodborne illnesses, inhibiting microbial growth, and maintaining the nutritional quality of food. However, gaseous ClO2 is sensitive to heat, vibration, and light, which limits its application. Methods: In this study, a ClO2 precursor-stabilized ClO2 aqueous solution was encapsulated by the double emulsion method, and a high-performance ClO2 self-releasing polyvinyl alcohol (PVA) film was prepared to investigate its performance and effect on blueberry quality during storage. Results: The self-releasing films had the best overall performance when the microcapsule content was 10% as the film's mechanical properties, thermal stability, and film barrier properties were significantly improved. The inhibition rates of Listeria monocytogenes and Escherichia coli were 93.69% and 95.55%, respectively, and the mycelial growth of Staphylococcus griseus was successfully inhibited. The resulting ClO2 self-releasing films were used for blueberry preservation, and an experimental study found that the ClO2 self-releasing antimicrobial film group delayed the quality decline of blueberries. During the 14-day storage period, no mold contamination was observed in the ClO2 self-releasing film group, and blueberries in the antibacterial film group had higher anthocyanin accumulation during the storage period. Discussion: Research analysis showed that films containing ClO2 microcapsules are promising materials for future fruit and vegetable packaging.

Recent advances in self-healing polyurethane based on dynamic covalent bonds combined with other self-healing methods.

To meet more application requirements, improving mechanical properties and self-healing efficiency has become the focus of current research on self-healing PU. The competitive relationship between self-healing ability and mechanical properties cannot be avoided by a single self-healing method. To address this problem, a growing number of studies have combined dynamic covalent bonding with other self-healing methods to construct the PU structure. This review summarizes recent studies on PU materials that combine typical dynamic covalent bonds with other self-healing methods. It mainly includes four parts: hydrogen bonding, metal coordination bonding, nanofillers combined with dynamic covalent bonding and multiple dynamic covalent bond bonding. The advantages and disadvantages of different self-healing methods and their significant role in improving self-healing ability and mechanical properties in PU networks are analyzed. At the same time, the possible challenges and research directions of self-healing PU materials in the future are discussed.

Correction: Recent advances in self-healing polyurethane based on dynamic covalent bonds combined with other self-healing methods.

Correction for 'Recent advances in self-healing polyurethane based on dynamic covalent bonds combined with other self-healing methods' by Ze-Wei An et al., Nanoscale, 2023, 15, 6505-6520, https://doi.org/10.1039/D2NR07110J.

Self-Healable, Solvent Response Cellulose Nanocrystal/Waterborne Polyurethane Nanocomposites with Encryption Capability.

Cellulose nanocrystal (CNC)-based chiral nematic structure is widely used in stimulus response and sensing. A popular area of research is enhancing the mechanical characteristics and environmental adaptability of chiral nematic materials. In this paper, a flexible photonic film with self-healing ability (FPFS) was prepared by combining waterborne polyurethane containing dynamic covalent disulfide bonds (SSWPU) with CNC. The results found that the FPFS showed excellent toughness under the action of stretching, bending, twisting, and folding. The FPFS exhibited an amazing self-healing efficiency, which can be self-healed within 2 h at room temperature. Moreover, the FPFS could respond immediately and produce reversible color change when it was soaked in typical solvents. In addition, when ethanol was used as ink to paint on the FPFS, a visible pattern only under polarized light was formed. This study offers fresh perspectives in the areas of self-healing, biological anticounterfeiting, solvent response, and flexible photonic materials.

Constructions of synergistic photothermal therapy antibacterial hydrogel based on polydopamine, tea polyphenols and polyvinyl alcohol and effects on wound healing in mouse.

Hydrogels with significant antibacterial efficacy have enormous potential in wound healing. This work reported a series of effective antibacterial and antioxidant hydrogels based on tea polyphenols (TP), polydopamine (PDA), and polyvinyl alcohol (PVA). PDA-TP molecular chains are formed from oxidized TP and PDA. These molecular chains, which were cross-linked with PVA by cyclic freeze-thaw (FT), formed the PVA/PDA-TP hydrogel (PPTP). The number of freezing-thawing cycles and the amount of TP would affect the mechanical properties and swelling properties of hydrogel. The PPTP hydrogel exhibited high photo thermal conversion efficiency, high antibacterial efficacy, antioxidant properties, good cellular compatibility and short wound closure time. The PPTP hydrogel leaded to wound closure in approximately 10 d in a full-thickness skin defect mouse model. The preparation method of hydrogel with non-chemical cross-linked and ability of rapid high temperature generation provided a new way to apply TP to wound healing and proved that synergistic chemical and photothermal therapy can effectively inhibit resistant bacteria and accelerate wound healing.

Effect of new type extrusion modification technology on supramolecular structure and in vitro glycemic release characteristics of starches with various estimated glycemic indices.

Nowadays, the highly effective modified technology to starch with various digestibility is gaining interest in food science. Here, the interactions between glycemic release characteristics and fine supramolecular structure of cassava (ECS), potato (EPS), jackfruit seed (EJFSS), maize (EMS), wheat (EWS), and rice starches (ERS) prepared with improved extrusion modification technology (IEMS) were investigated. The crystalline structures of all extruded cooking starches changed from the A-type to V-type. IEMS-treated cassava, potato, and rice starches had broken α-1.6-glycosidic amylopectin (long chains). The others sheared α-1.4-glycosidic amylopectin. The molecular weight, medium and long chain counts, and relative crystallinity decreased, whereas the number of amylopectin short chains increased. The glycemic index (GI) and digestive speed rate constant (k) of ECS, EPS, EJFSS, and EWS were improved compared to those of raw starch. Although EMS and ERS had degraded molecular structures, their particle morphology changed from looser polyhedral to more compact with less enzymolysis channels due to the rearrangement of side chain clusters of amylopectin, leading to enzyme resistance. The starch characteristics of IEMS-treated samples significantly differed. EPS had the highest amylose content, medium chains, long chains, and molecular weight but lowest GI, relative crystallinity, and k. ERS showed the opposite results. Thus, IEMS may affect starches with different GIs to varying degrees. In this investigation, we provide a basis for wider applications of conventional crop starch in the food industry corresponding to different nutrition audience.

Antimicrobial food packaging integrating polysaccharide-based substrates with green antimicrobial agents: A sustainable path.

Food spoilage and waste, human and animal poisoning, and even death caused by foodborne microorganisms remain extensive concerns in food safety. The global demand for functional, eco-friendly, and efficient antimicrobial food packaging is increasing. However, the bacteriostatic or bactericidal effects of most conventional food packaging display limited action, and their major components are petrochemical materials (non-renewable, non-biodegradable, and not environmentally friendly), and the current target microorganisms easily acquire drug-resistant. Therefore, the development of more effective, sustainable and safe antimicrobial materials has become a research hotspot in food packaging. This paper systematically reviews the latest research on antimicrobial active packaging materials combining renewable and biodegradable polysaccharide-based substrates with green organic guanidine-based polymers, inorganic chlorine dioxide, or natural antimicrobial agents (such as essential oils, other plant extracts, chitosan, propolis, protein, bacteriocin, probiotics, and bacteriophages). The compositions, characteristics, antimicrobial mechanisms, and food applications of the various types of sustainable antimicrobial materials are updated, and future trends are explored. Although they show impressive properties, further studies are required to confirm the safety and efficacy of these materials as a majority of the studies have been conducted under laboratory conditions. This review provides theoretical and technical support for the development of new antimicrobial food packaging and extending the shelf-life of foods.