Seasonal variation of transport pathways and potential source areas at high inorganic nitrogen wet deposition sites in southern China.

This study attempts to identify the dominant transport pathways, potential source areas, and their seasonal variation at sites with high inorganic nitrogen (IN) wet deposition flux in southern China. This is a long-term study (2010-2017) based on continuous deposition measurements at the Guangzhou urban site (GZ) and the Dinghushan Natural Reserve site (DHS) located in the Pearl River Delta (PRD) region. A dataset on monthly IN concentration in precipitation and wet deposition flux were provided. The average annual fluxes measured at both sites (GZ: 33.04±9.52, DHS: 20.52±10.22 kg N/(ha∙year)) were higher, while the ratios of reduced to oxidized N (GZ: 1.19±0.77, DHS: 1.25±0.84) were lower compared with the national mean level and the previous reported level throughout the PRD region. The dominant pathways were not always consistent with the highest proportional trajectory clusters. The transport pathways contributing most of deposition were identified in the north and north-northeast in the dry season and in the east-southeast, east, and south-southwest in the wet season. A weighted potential source contribution function (WPSCF) value >0.3 was determined reasonably to define the potential source area. Emission within the PRD region contributed the majority (≥95% at both sites) of the IN deposition in the wet season, while the contribution outside the region increased significantly in the dry season (GZ: 27.86%, DHS: 95.26%). Our results could help create more effective policy to control precursor emissions for IN fluxes, enabling reduction of the ecological risks due to excessive nitrogen.

Atmospheric Arsenic Deposition in the Pearl River Delta Region, South China: Influencing Factors and Speciation.

This is a comprehensive study on mobilization/speciation and temporal/spatial variation of atmospheric arsenic (As) deposition in the Pearl River Delta (PRD) region. A set of experimental procedures was established for measuring the deposition fluxes of individual As species. The deposition carrying inorganic AsIII % was significantly higher than that contained in atmospheric particles. Compared with dry deposition, wet deposition was much more harmful to the regional ecosystem, as it contributed the majority of bulk deposition (>75%) and carried most of the mobilized iAsIII compounds. A stepwise linear regression model was utilized to identify the factors influencing total As deposition (wet: precipitation and PM2.5, dry: relative humidity, wind speed, and PM10, bulk: precipitation, PM2.5, and wind speed). By examining the representativeness of the study sites and comparison with the literature data, the statistic models were verified to explain the temporal/spatial variation of total As deposition in the entire PRD region, where significant seasonal variation was only found for wet deposition (wet season > dry season). The annual As load contributed from regional atmospheric deposition increased from 2013 to 2015, when the contributions of individual cities varied annually.

Wet and dry deposition fluxes of heavy metals in Pearl River Delta Region (China): Characteristics, ecological risk assessment, and source apportionment.

The atmospheric deposition of heavy metals poses serious risks to the ecological system and human health. To advance our knowledge of atmospheric dry/wet heavy metal deposition in the PRD region, monthly fluxes were examined based on soluble/insoluble fractions of five heavy metal elements (Cu, Pb, Cd, Cr and Zn) in samples collected from January 2014 to December 2015 at Guangzhou (urban) and Dinghushan (suburban) sites. The ratios of wet/dry deposition fluxes indicated that heavy metal deposition was governed by wet deposition rather than dry deposition in the PRD region. Affected by the shifting of the Asian monsoon, wet deposition fluxes exhibited significant seasonal variation between summer monsoon seasons (April to September) and winter monsoon seasons (October to February) in this region. Cd was classified as an extremely strong potential ecological risk based on solubility and the Hakanson ecological risk index. Source contributions to wet deposition were calculated by PMF, suggesting that dust, biomass burning, industries, vehicles, long-range transport and marine aerosol sources in Guangzhou, and Zn fertilizers, marine aerosol sources, agriculture, incense burning, biomass burning, vehicles and the ceramics industry in Dinghushan, were the potential sources of heavy metals.

Impacts of Atmospheric Mercury Deposition on Human Multimedia Exposure: Projection from Observations in the Pearl River Delta Region, South China.

A preliminary projection was performed to determine human multimedia exposure to mercury (Hg) based on deposition flux observations and to identify the impacts of atmospheric Hg deposition in Pearl River Delta (PRD) region, South China. The Monte Carlo technique was used to propagate the variability throughout the projection. The regional specific probability density functions (PDFs) of the studied parameters were regressed from the provincial/national published data, except when the data were deficient. The atmospheric Hg deposition flux ranged from 43.70 to 321.19 µg/m2/year and did not significantly contribute to Hg accumulation in the regional topsoil, freshwater bodies, and most food items except fish. The consumption of fish and milk/dairy products was the major contributor to the total exposure for adults (>18 years)/6- to 12-year children and 0- to 6-year children, respectively. The projected concentrations and exposure levels were the results combining MeHg and inorganic Hg (Hg2+). Under the 30-year projection, the probability of risks caused by Hg deposition (combining Hg2+ and MeHg) was the highest for 0- to 6-year children, followed by 6- to 12-year children and adults. The ground effects driven by precipitation had a significantly greater effect relative to the mass transport effects in this region.

Risk assessment of arsenic and other metals via atmospheric particles, and effects of atmospheric exposure and other demographic factors on their accumulations in human scalp hair in urban area of Guangzhou, China.

Eighty-eight scalp hair samples were collected from Guangzhou (GZ) urban population (15-65 years) to investigate the accumulation of As and other metals (Cr, Mn, Ni, Cu, Zn, Cd, Sn, Sb, Hg and Pb). Demographic information, including body weight, height, age, gender, habits of smoking and drinking, types of drinking water, duration of stay in GZ, days of stay in GZ per year (days/year), and hours spent in indoor environment per day (h/day), were also recorded during hair sampling to refine the uncertainty of risk assessment derived from exposures to elements via dust and airborne particles. No significant non-carcinogenic risk was found. However, the cancer risks of Cr and As for both ingestion and inhalation exceeded the most tolerable regulated level (1.0×10(-6)). The environmental exposures to urban dust and airborne particles were observed significantly correlated to accumulations of Cd (R=0.306, p=0.005) and Ni (R=0.333, p=0.002) in scalp hair. Furthermore, the hair burden of elements was also significantly (p<0.05) dependent on gender (Mn, Ni, Zn, As, Sn and Hg), age (Cr, As, Cd and Hg), duration of stay in GZ (Hg) as well as nutritional and physical status, reflected by BMI and BSA (Cr, Ni, Cd, Sb and Hg). Nutritional and physical status was observed as the exclusive important factor influencing As speciation in human scalp hair. However, habits of smoking and alcohol drinking as well as types of drinking water were not identified as the significant influencing factors on any element (p>0.05).

Applicability of evaluation metrics/schemes for human health burden attributable to regional ozone pollution: A case study in the Guangdong-Hong Kong-Macao Greater Bay Area (GBA), South China.

This is a study to identify the applicable/preferable short- and long-term metrics/schemes to evaluate the premature mortality attributable to the ozone pollution in the Guangdong-Hong Kong-Macao Greater Bay Area (GBA), one of the most representative populous ozone pollution regions in China, by comprehensively accounting the uncertainty sources. The discrepancy between the observation and the CAQRA reanalysis datasets (2013-2019) was investigated in terms of the concentration variation pattern, which determines the exposure metric change. A set of domestic short-term C-R coefficients for the all-age population were integrated using the meta-analysis respectively corresponding to the metrics of MDA1, MDA8, and Daily average. The dataset-based deviations of the short-term attributable factors (AFs) and their corresponding premature mortalities were respectively about 16.9 ± 13.3 % and <5 % based on MDA8, much smaller than other two metrics; and the MDA8-based evaluation results were the most sensitive to the deteriorative ozone pollution, with the maximum upward trends of 0.095-0.129 %/year. Accordingly, MDA8 was recognized as the most applicable short-term metric. For the long-term exposure, the domestic summer metric SMDA8 could not exactly represent the peak-season ozone maximum level in the GBA, with the deviation from 6MMDA8 as much as 30 %. By considering the ability of metric to represent the peak-season ozone, the relatively smaller dataset-based discrepancies of AFs (6MMDA8-WHO2021: 23.3 ± 16.9 %, AMDA8-T2016: 20.7 ± 15.8 %) and the attributable premature mortalities (6MMDA8-WHO2021: 5 %, AMDA8-T2016: 8 %), and the higher sensitivity of the evaluation results to the deteriorative ozone pollution (6MMDA8-WHO2021: 0.13 %;year, p = 0.01; AMDA8-T2016: 0.15 %/year, p = 0.03), the schemes of 6MMDA8-WHO2021 and AMDA8-T2016 were recognized relatively more preferable for the adult (≥25-year) long-term evaluation. Based on the recognized metric/schemes, the central and the eastern PRE areas of higher NO2 level in the GBA were experiencing the highest health burdens from 2013 to 2019.

Mercury levels in road dust and household TSP/PM2.5 related to concentrations in hair in Guangzhou, China.

Road dust, household total suspended particulate matters (TSP) and PM2.5 were collected in urban area of Guangzhou, south of China, to investigate the concentrations of total mercury (THg) and methyl mercury (MeHg). The household PM2.5 concentrations varied between 16.2 and 623 µg/m³. The average PM2.5 level (174 µg/m³) from all of the locations exceeded 24-h concentration from WHO air quality guideline The average concentrations of THg and MeHg were: 235 µg/kg and 0.392 µg/kg in road dust, 600 µg/kg and 1.49 µg/kg in TSP; 1006 µg/kg (104 pg/m³) and 1.40 µg/kg (0.134 pg/m³) in PM2.5. Risk assessment showed that the Hazardous quotients (HQs) of exposure to Hg and MeHg via road dust and TSP were less than 1, indicating that no adverse risk was manifested. Ingestion of dust was found to constitute a relatively minor pathway of Guangzhou residents' exposure to Hg. Furthermore, human hair samples from 88 Guangzhou citizens were also analyzed to investigate the mercury accumulation in human body in Guangzhou. The average concentrations of THg and MeHg in human hair samples were 869±831 µg/kg and 104±108 µg/kg respectively. However, no significant correlations of the mercury species were noted between human hair and road dust, TSP and PM2.5.

Pollution evaluation and children's multimedia exposure of atmospheric arsenic deposition in the Pearl River Delta, China.

The populous Pearl River Delta (PRD) region in China suffers from serious air arsenic (As) pollution. The objective of this study was to explore the pollution situation of atmospheric arsenic deposition in the PRD region, and to evaluate the associated multimedia daily intake in children. The average deposition flux was 3921.7 µg/m2/year during the 2016-2017, and the pollution situation was even worse than that in 2015. A continuously increasing trend of arsenic atmospheric deposition was found. The bioaccessibility of As in the settled dust was determined as about 22% by a physiologically based extraction test (PBET). After corrected with the bioaccessibilities of As in the settled dust and food items, the geometry means (GM) value of daily uptake through multimedia ingestion of produce (dust and diet) originated from arsenic atmospheric deposition was 0.23 µg/kg/day for 1- to 6-year-old children. The contribution of the non-dietary oral exposure (settled dust) was negligible and just accounted for only 0.01% of the daily uptake. This estimated value was much lower than those in the literatures, in which the bioaccessibility of As was not taken into account, concluding that the role of the settled dust in the total daily intake may have been overestimated previously. Milk, eggs and freshwater fish were the dominant pathways for children to intake the products derived from atmospheric arsenic deposition. There still be a concern about the high non-carcinogenic and carcinogenic risk by long-term multimedia ingestion. Special care should be considered toward the emission sources of air arsenic, including the coal combustion from industries and construction dust, etc., to reduce the negative effect of air arsenic in children.

A quantitative analysis of the driving factors affecting seasonal variation of aerosol pH in Guangzhou, China.

Aerosol acidity is of great interest due to its effects on atmospheric chemical processes and impact on human health; however, the driving factors of aerosol acidity have only been scarcely investigated. This study characterized the aerosol acidity during the wet and dry seasons in Guangzhou, China, and systematically analyzed the seasonal variation and the corresponding driving factors of aerosol acidity followed by the discussion of their impact on gas-aerosol partitioning of NH3 and HNO3. It was demonstrated that the pH of PM2.5 was 0.08 unit lower (more acidic) during wet season than during the dry season and the aerosol acidity varied less in South China than that in North China. Additionally, our results showed that the meteorological parameters including temperature and relative humidity have larger effect on aerosol pH variation than chemical species. Particularly, the lower temperature during dry season had the positive influence (0.38 pH unit) on aerosol pH compared to the wet season; however, the negative effect due to relative humidity (RH) and chemical species resulted in a smaller seasonal variation of aerosol pH between these two seasons. The sensitivity analysis showed that the increase of temperature has negative impact (reducing pH) on aerosol pH with an almost linear relationship, while RH and chemical species represented a two-phase linear and nonlinear effect, respectively. Finally, the calculation of gas-aerosol partitioning indicated that the temperature had the largest influence on the seasonal variation of gas-aerosol partitioning for both HNO3 and NH3 followed by liquid water content and non-ideality, while aerosol acidity imposed the lowest impact, which suggests that all the parameters including meteorological and chemical species should be comprehensively evaluated to devise a PM2.5 control strategy.

Trends of outdoor air pollution and the impact on premature mortality in the Pearl River Delta region of southern China during 2006-2015.

Severe air pollution in the Pearl River Delta (PRD) region of southern China has increased attention of both the scientific community and policy makers. Air quality data collected at the PRD Regional Air Quality Monitoring Network during 2006-2015 were analyzed for assessing the effectiveness of pollution control measures and for estimating the trends of premature mortality attributable to ambient PM2.5 and O3. Statistically significant decreasing trends were detected for PM2.5 (-1.74 to -1.83 µg m-3 yr-1), PM10 (-2.70 to -2.78 µg m-3 yr-1), NO (-0.61 to -0.74 µg m-3 yr-1), NO2 (-1.20 to -1.22 µg m-3 yr-1), and SO2 (-3.46 to -4.01 µg m-3 yr-1), while an increasing trend was found for O3 (0.70-0.86 µg m-3 yr-1) during the study period. The findings demonstrate the effectiveness of control measures implemented in the last decade for primary pollutants and also indicate the challenges for controlling secondary pollutants. The PM2.5-related premature deaths varied little, e.g., from 40.6 thousand deaths in 2006 to 40.4 thousand deaths in 2015, due to the two contrasting factors, i.e., the decreased PM2.5 concentration and increased population. The increases in both O3 concentration and exposed population resulted in a significant rising trend for the O3-related premature deaths, which increased from 2.7 thousand deaths in 2006 to 4.5 thousand deaths in 2015, at a rate of 165 deaths yr-1. Consistent with the spatial distribution of air pollution and population density, high levels of premature deaths from PM2.5 and O3 were located in the central PRD including Guangzhou, Foshan, Dongguan, and Shenzhen. Decreasing PM2.5 concentration is the most effective way in reducing the regional mortality burden from air pollution in the near future. Besides controlling primary emissions of PM2.5, reducing VOCs emissions is also important for limiting atmospheric oxidizing capacity and associated secondary PM2.5 formation.

Projections of long-term human multimedia exposure to metal(loid)s and the health risks derived from atmospheric deposition: A case study in the Pearl River Delta region, South China.

This is one of a limited number of studies that investigates multimedia exposure to metal(loid)s and the related human health risks caused by atmospheric deposition in China and Asia. The aggregate multimedia human exposure included the accidental ingestion and dermal adsorption of soil and surface water, as well as the intake of grains, fruits, vegetables, meats and eggs, milk and dairy products, and freshwater fish. The values and variabilities of atmospheric deposition and exposure factors were identified as two major uncertainty sources. The annual variations in wet and bulk deposition were propagated from the variabilities of particulate matter (PM) × precipitation and the linear regressed coefficients of flux~PM × precipitation, and the annual variation in dry deposition was propagated by subtracting the wet deposition from the bulk deposition. The variabilities in the exposure factors were updated based on the latest published regional data. Long-term atmospheric deposition was identified as a vital source of Cd contamination in surface soil and freshwater bodies and As accumulation in freshwater fish. The noncarcinogenic (NC) risk probabilities caused by Cd were the highest, followed by As. The overall uncertainties related to the NC risk probabilities were much lower for both adults and 6- to 17-year-old children/adolescents, while those related to the carcinogenic risk (CR) probabilities were much lower for 2- to 5-year-old children and 6- to 17-year-old children/adolescents. Our results could help infer the cobenefits due to the current regional air pollution control policy.

Characterization of diurnal variations of PM2.5 acidity using an open thermodynamic system: A case study of Guangzhou, China.

Aerosol acidity has significant implications for atmospheric processing, and high time-resolution measurements can provide critical insights into those processes. This paper reports diurnal variations of aerosol acidity characterized using an open thermodynamic system in Guangzhou, China. Hourly measurements of PM2.5-associated ionic species and related parameters were carried out during June-September 2013 followed by application of the Extended Aerosol Inorganic Model in open mode to estimate aerosol pH. The model-estimated aerosol pH was 2.4 ±â€¯0.3, and the pH diurnal profile exhibited peaks in the early morning (6 a.m.) and troughs in the afternoon (2 p.m.) that appeared to be constrained by liquid water content (LWC) and free H+. A linear regression model was developed to predict aerosol pH, which performed strongly with 4 variables during daytime (NH4+, Na+, SO42- and RH; R2 = 0.95) and 3 during nighttime (NH4+, SO42- and RH; R2 = 0.91). The effect of aerosol acidity on the partitioning of HNO3, HCl and NH3 was studied based on theoretical considerations and measurement data. The fractions in particulate phase for acidic compounds correlated strongly with pH (R2 = 0.64-0.69) while that for NH3, interestingly, was weak (R2 = 0.17). Analytical expressions were developed to explain these observations and it was concluded that the partitioning of HCl and HNO3 was more sensitive to pH compared to that of NH3. These results are significant in terms of potential atmospheric depletion rates of HCl and HNO3 in the region and stress the need for future studies in this direction.

Alkyl Side-Chain Engineering in Wide-Bandgap Copolymers Leading to Power Conversion Efficiencies over 10.

A series of wide-bandgap (WBG) copolymers with different alkyl side chains are synthesized. Among them, copolymer PBT1-EH with moderatly bulky side chains on the acceptor unit shows the best photovoltaic performance with power conversion efficiency over 10%. The results suggest that the alkyl side-chain engineering is an effective strategy to further tuning the optoelectronic properties of WBG copolymers.

High time-resolved elemental components in fine and coarse particles in the Pearl River Delta region of Southern China: Dynamic variations and effects of meteorology.

Hourly-resolved PM2.5 and PM10-2.5 samples were collected in the industrial city Foshan in the Pearl River Delta region, China. The samples were subsequently analyzed for elemental components and black carbon (BC). A key purpose of the study was to understand the composition of particulate matter (PM) at high-time resolution in a polluted urban atmosphere to identify key components contributing to extreme PM concentration events and examine the diurnal chemical concentration patterns for air quality management purposes. It was found that BC and S concentrations dominated in the fine mode, while elements with mostly crustal and oceanic origins such as Si, Ca, Al and Cl were found in the coarse size fraction. Most of the elements showed strong diurnal variations. S did not show clear diurnal variations, suggesting regional rather than local origin. Based on empirical orthogonal functions (EOF) method, 3 forcing factors were identified contributing to the extreme events of PM2.5 and selected elements, i.e., urban direct emissions, wet deposition and a combination of coarse mode sources. Conditional probability functions (CPF) were performed using wind profiles and elemental concentrations. The CPF results showed that BC and elemental Cl, K, Fe, Cu and Zn in the fine mode were mostly from the northwest, indicating that industrial emissions and combustion were the main sources. For elements in the coarse mode, Si, Al, K, Ca, Fe and Ti showed similar patterns, suggesting same sources such as local soil dust/construction activities. Coarse elemental Cl was mostly from the south and southeast, implying the influence of marine aerosol sources. For other trace elements, we found vanadium (V) in fine PM was mainly from the sources located to the southeast of the measuring site. Combined with CPF results of S and V in fine PM, we concluded shipping emissions were likely an important elemental emission source.

Potential cytotoxicity of water-soluble fraction of dust and particulate matters and relation to metal(loid)s based on three human cell lines.

Hepatocellular liver carcinoma (HepG2), human skin derived keratinocyte (KERTr,) and lung epithelial carcinoma (A549) were employed in MTT assay to evaluate the cytotoxicity of water-soluble fraction of road dust, air-conditioning (AC) filter dust and PM2.5 via ingestion, dermal contact and inhalation. Their effects on cell growth were dependent on exposure time and concentration. The LC20s of PM2.5 for A549 cell were approximately one order of magnitude lower than those of road dust and AC filter dust for KERTr cell and HepG2 cell. The LC20s of aqueous extracts were negatively correlated to the water-soluble metal(loid)s contained in dust coarse particles (KERTr: p=0.004; HepG2: p<0.001). However, no significant correlation between soluble metal(loid)s and LC20s of PM2.5 was observed for A549 cell (p>0.05). Other water-soluble components in dust and PM might cause the cell hazards synergistically or additively with metal(loid)s.

Arsenic speciation in total contents and bioaccessible fractions in atmospheric particles related to human intakes.

Speciation of inorganic trivalent arsenicals (iAs(III)), inorganic pentavalent arsenicals (iAs(V)), monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) in total arsenic (As) content and its bioaccessible fractions contained in road dust, household air-conditioning (AC) filter dust and PM2.5 was investigated. Inorganic As, especially iAs(V), was observed as the dominant species. Physiologically based extraction test (PBET), an in-vitro gastrointestinal method, was used to estimate the oral As bioaccessibility in coarse particles and the species present in the oral bioaccessible fraction. A composite lung simulating serum was used to mimic the pulmonary condition to extract the respiratory bioaccessible As and its species in PM2.5. Reduction of iAs(V) to iAs(III) occurred in both in-vitro gastrointestinal and lung simulating extraction models. The inorganic As species was the exclusive species for absorption through ingestion and inhalation of atmospheric particles, which was an important exposure route to inorganic As, in addition to drinking water and food consumption.

Contamination and risk assessment (based on bioaccessibility via ingestion and inhalation) of metal(loid)s in outdoor and indoor particles from urban centers of Guangzhou, China.

Road dust, household air-conditioning (AC) filter dust and PM2.5 were collected to investigate the contamination of metal(loid)s (Cr, Mn, Ni, Cu, Zn, As, Cd, Sn, Sb, Hg and Pb) in outdoor and indoor urban environments of Guangzhou. Zinc was found to be the most abundant element in road dust and household PM2.5, while the concentration of Pb was the highest in AC filter dust. Enrichment factor (EF) was used to assess the influence of human activity on the contamination of these metal(loid)s. Ingestion and inhalation were the two exposure pathways applied for risk assessment. Physiologically based extraction test (PBET) was used to estimate the oral bioaccessibilities of metal(loid)s in road dust and AC filter dust. Respiratory bioaccessible fraction of metal(loid)s via household PM2.5 was extracted with lung simulating solution. Household AC filter dust was more hazardous to human health than road dust, especially to children. Arsenic was found to be the most risky element based on the risk assessment.

Exposure assessment and distribution of polychlorinated biphenyls (PCBs) contained in indoor and outdoor dusts and the impacts of particle size and bioaccessibility.

The size fraction, bioaccessibility and associated human daily intake of PCBs via indoor and outdoor dust collected from two most populated urban centers of Pearl River Delta (PRD), China, were studied. The ΣPCBs levels (ng g(-1)) in indoor (51.9-264) and outdoor (4.02-228) dust in Guangzhou (GZ) were found higher than those in indoor (17.4-137) and outdoor (7.75-114) dust of Hong Kong (HK). Hexa-PCB was the largest contributor in dust samples (29-64%), followed by tri-PCB. The size fraction of PCBs indicated a high accumulation effect of particles less than 63 µm, while the lowest was found in 280-2000 µm. Toxic equivalency (TEQ) of dioxin-like PCBs in indoor dust of GZ and HK was 2 to 13 times higher than that in outdoor dust. The bioaccessibility of PCBs was determined as 5-61% depending on individual PCB congeners under study and bioaccessible PCB exposure was significantly lower than the estimate for total PCB. The daily intake of bioaccessible PCBs via dust ranged in 0.02-8.95 and 0.37-17.8 ng day(-1) in GZ while 0.01-4.95 and 0.16-9.83 ng day(-1) in HK for adults and children, respectively. Dust ingestion contributed to 0.49-10.6% of overall non-dietary PCB exposure (dust ingestion and inhalation) for adults while 12.9-35% for children, indicating the dominant contribution from inhalation.

Hair mercury levels and food consumption in residents from the Pearl River Delta: South China.

The Pearl River Delta (PRD) is located in the Southern part of China and is the main region for fish culture in Guangdong Province. In order to assess the potential health risks associated with dietary consumption of mercury, hair samples from 91 urban, town and fishing village residents, 37 species of fish, cereal, vegetables, and meat samples were collected. The average total mercury (THg) and methylmercury (MeHg) concentrations in hair were 1.08 ± 0.94 and 0.58 ± 0.59 µg/g, respectively. Daily Hg intake via fish consumption is significantly correlated with THg and MeHg accumulated in human hair (r=0.48, p<0.01; r=0.43, p<0.01). The estimated daily intake of Hg via different food types showed that both fish and cereal consumption were the two main routes of Hg exposure for residents in the sampling areas. Besides food intake, smoking was also an important source for daily THg intake in the smoke group, contributing 11-18% to EDI of THg.

Size fraction effect on phthalate esters accumulation, bioaccessibility and in vitro cytotoxicity of indoor/outdoor dust, and risk assessment of human exposure.

Indoor and outdoor dusts from two urban centers in the Pearl River Delta, China, were analyzed and phthalate esters varied from 4.95 to 2,220 µg g(-1) in indoor dust, significantly higher than outdoor dust (1.70-869 µg g(-1)). Di-2-ethylhexyl phthalate (DEHP) was the dominant phthalate found and the highest distribution factor (DF) (1.56 ± 0.41) was noted in the <63 µm fraction (p<0.05). In vitro cytotoxicity of dust extract on human T cell lymphoblast leukemic cell line (CCRF-CEM) indicated by Lethal Concentration 50 (LC50) decreased with particle size. The power model was found as a better fit for explaining the relationship between LC50 and phthalates (R(2)=0.46, p<0.01). Bioaccessibility of phthalates in dust varied with different particle sizes, with the greatest bioaccessible fraction (2.49-38.6%) obtained in <63 µm. Risk assessment indicated that indoor dust ingestion accounted for the major source for DEHP exposure (81.4-96.4% of non-dietary exposure and 36.5% of total exposure), especially for toddlers. The cancer risks associated with DEHP via home dust were high (10(-6)-10(-4)), with 10% of houses estimated with unacceptable risks (>10(-4)). After corrected with the bioaccessibility of phthalates, the cancer risks of dust exposure were moderate (10(-7)-10(-5)).