Detalhe da pesquisa
1.
Discovery of LHF418 as a new potent SOS1 PROTAC degrader.
Bioorg Med Chem
; 103: 117661, 2024 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38489998
2.
Design, synthesis and evaluation of thieno[3,2-d]pyrimidine derivatives as novel potent CDK7 inhibitors.
Bioorg Chem
; 148: 107456, 2024 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-38761706
3.
Neuronal K+-Cl- cotransporter KCC2 as a promising drug target for epilepsy treatment.
Acta Pharmacol Sin
; 45(1): 1-22, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37704745
4.
A novel photocaged B-RafV600E inhibitor toward precise melanoma treatment.
Bioorg Med Chem Lett
; 64: 128683, 2022 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35307569
5.
Colorimetric determination of the early biomarker hypoxia-inducible factor-1 alpha (HIF-1α) in circulating exosomes by using a gold seed-coated with aptamer-functionalized Au@Au core-shell peroxidase mimic.
Mikrochim Acta
; 187(1): 61, 2019 12 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31853650
6.
Discovery of 5-aminopyrido[2,3-d]pyrimidin-7(8H)-one derivatives as new hematopoietic progenitor kinase 1 (HPK1) inhibitors.
Eur J Med Chem
; 269: 116310, 2024 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38479166
7.
Design and Synthesis of Novel Macrocyclic Derivatives as Potent and Selective Cyclin-Dependent Kinase 7 Inhibitors.
J Med Chem
; 67(8): 6099-6118, 2024 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38586950
8.
Mechanisms of acquired resistance to HER2-Positive breast cancer therapies induced by HER3: A comprehensive review.
Eur J Pharmacol
; 977: 176725, 2024 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38851563
9.
Discovery of LWY713 as a potent and selective FLT3 PROTAC degrader with in vivo activity against acute myeloid leukemia.
Eur J Med Chem
; 264: 115974, 2024 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38007910
10.
Discovery of LLC355 as an Autophagy-Tethering Compound for the Degradation of Discoidin Domain Receptor 1.
J Med Chem
; 67(10): 8043-8059, 2024 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38730324
11.
Discovery of LLC0424 as a Potent and Selective in Vivo NSD2 PROTAC Degrader.
J Med Chem
; 67(9): 6938-6951, 2024 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38687638
12.
Discovery of AXL Degraders with Improved Potencies in Triple-Negative Breast Cancer (TNBC) Cells.
J Med Chem
; 66(3): 1873-1891, 2023 02 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36695404
13.
Discovery of a First-in-Class Degrader for the Lipid Kinase PIKfyve.
J Med Chem
; 66(17): 12432-12445, 2023 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37605297
14.
Hydrogen sulfide functions as a micro-modulator bound at the copper active site of Cu/Zn-SOD to regulate the catalytic activity of the enzyme.
Cell Rep
; 42(7): 112750, 2023 07 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37421623
15.
Targeting the Non-Catalytic Functions: a New Paradigm for Kinase Drug Discovery?
J Med Chem
; 65(3): 1735-1748, 2022 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35000385
16.
Application of serum exosomal hypoxia-inducible factor-1 alpha (HIF-1α) as potential circulating biomarker for bacterial peritonitis.
Bioengineered
; 13(2): 1975-1987, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34898382
17.
Discovery of a Highly Potent and Selective Dual PROTAC Degrader of CDK12 and CDK13.
J Med Chem
; 65(16): 11066-11083, 2022 08 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-35938508
18.
Carbonyl reductase 1 as a novel target of (-)-epigallocatechin gallate against hepatocellular carcinoma.
Hepatology
; 52(2): 703-14, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20683966
19.
Structural insights into xylanase mutant 254RL1 for improved activity and lower pH optimum.
Enzyme Microb Technol
; 147: 109786, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-33992408
20.
Decreased expression of the human carbonyl reductase 2 gene HCR2 in hepatocellular carcinoma.
Cell Mol Biol Lett
; 11(2): 230-41, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16847567