Detalhe da pesquisa
1.
New Associations between Drug-Induced Adverse Events in Animal Models and Humans Reveal Novel Candidate Safety Targets.
Chem Res Toxicol
; 34(2): 438-451, 2021 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33338378
2.
Prospectively Validated Proteochemometric Models for the Prediction of Small-Molecule Binding to Bromodomain Proteins.
J Chem Inf Model
; 58(9): 1870-1888, 2018 09 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30125501
3.
Colonization and diversification of aquatic insects on three Macaronesian archipelagos using 59 nuclear loci derived from a draft genome.
Mol Phylogenet Evol
; 107: 27-38, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27742475
4.
Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors.
J Med Chem
; 67(2): 1500-1512, 2024 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38227216
5.
Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists.
J Med Chem
; 66(4): 2918-2945, 2023 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36727211
6.
Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models.
J Med Chem
; 65(4): 3306-3331, 2022 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35133824
7.
Fragment based discovery of a novel and selective PI3 kinase inhibitor.
Bioorg Med Chem Lett
; 21(21): 6586-90, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21925880
8.
Structural basis of the effect of activating mutations on the EGF receptor.
Elife
; 102021 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34319231
9.
DPP1 Inhibitors: Exploring the Role of Water in the S2 Pocket of DPP1 with Substituted Pyrrolidines.
ACS Med Chem Lett
; 10(8): 1222-1227, 2019 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31413809
10.
PELE-MSM: A Monte Carlo Based Protocol for the Estimation of Absolute Binding Free Energies.
J Chem Theory Comput
; 15(11): 6243-6253, 2019 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31589430
11.
Molecular dynamics simulations of LysRS: an asymmetric state.
Proteins
; 62(3): 649-62, 2006 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16317719
12.
Potent, Selective, and CNS-Penetrant Tetrasubstituted Cyclopropane Class IIa Histone Deacetylase (HDAC) Inhibitors.
ACS Med Chem Lett
; 7(1): 34-9, 2016 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26819662
13.
Functional asymmetry in the lysyl-tRNA synthetase explored by molecular dynamics, free energy calculations and experiment.
BMC Struct Biol
; 3: 5, 2003 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-12787471
14.
TAK1 inhibition in the DFG-out conformation.
Chem Biol Drug Des
; 82(5): 500-5, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23745990
15.
Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease.
J Med Chem
; 54(22): 7797-814, 2011 Nov 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-21888439