RESUMO
A 38-year-old man with rheumatoid arthritis developed colitis after a course of 320 mg sodium aurothiomalate. Recovery comparable with that reported with corticosteroids or chelating agents was achieved by fluid replacement alone. Mucosal recovery was confirmed by measurement of rectal potential differences.
Assuntos
Enterocolite Pseudomembranosa/induzido quimicamente , Tiomalato Sódico de Ouro/efeitos adversos , Adulto , Enterocolite Pseudomembranosa/terapia , Hidratação , Humanos , Mucosa Intestinal/patologia , Masculino , Reto/patologiaRESUMO
1 Measurement of changes in trans-mural rectal potential difference (t.m.r.p.d.) and plasma aldosterone levels have been used in a comparison of the extra-renal activities of spironolactone and its major metabolite canrenone. 2 A characteristic pressure artifact was observed during measurement of t.m.r.p.d. When pressure artifacts were eliminated, there was a log-linear relationship between increasing doses of intravenous aldosterone and maximum increase in t.m.r.p.d. 3 Pre-treatment for 5 days with spironolactone or canrenone produced a similar attenuation of the increase in t.m.r.p.d. produced by infused aldosterone, suggesting that canrenone is the active metabolite of spironolactone in the rectum. This is in contrast to the significantly greater renal activity of spironolactone that has been demonstrated after a similar treatment period. Neither antagonist treatment produced significant changes in pre-infusion plasma aldosterone concentrations. 4 The need for assay of the extra-renal activities of aldosterone antagonists in the assessment of their therapeutic potential is discussed.
Assuntos
Aldosterona/sangue , Canrenona/farmacologia , Potenciais da Membrana/efeitos dos fármacos , Pregnadienos/farmacologia , Espironolactona/farmacologia , Humanos , Masculino , Pessoa de Meia-Idade , Antagonistas de Receptores de Mineralocorticoides , Pressão , Reto , Fatores de TempoRESUMO
Measurement of changes in buccal mucosal potential difference produced by contact with drug formulations may provide a means of predicting their mucosal toxicity and ulcerogenic activity.
Assuntos
Emeprônio/efeitos adversos , Doenças da Boca/induzido quimicamente , Mucosa Bucal/fisiopatologia , Propantelina/efeitos adversos , Compostos de Amônio Quaternário/efeitos adversos , Adulto , Idoso , Bochecha , Emeprônio/farmacologia , Feminino , Humanos , Potenciais da Membrana/efeitos dos fármacos , Mucosa Bucal/efeitos dos fármacos , Propantelina/farmacologia , Úlcera/induzido quimicamenteRESUMO
Twenty final year medical students had their ability to interpret rheumatological physical signs tested by 10 multiple choice questions (MCQ) on days 1 and 4 of an educational study. Ten theory questions were used as controls. They were then given an information sheet on the interpretation of physical signs, and repeated the MCQ on day 26. There was a progressive improvement in the theory scores but no improvement in clinical scores until after the information sheet was available. The improvement in clinical scores was significantly greater than the improvement in theory scores (P less than 0.001). We suggest that the use of an information sheet in conjunction with an MCQ paper can improve undergraduates' ability to interpret physical signs when used in the pattern test/inform/retest.