Detalhe da pesquisa
1.
Scientific and Regulatory Policy Committee Points to Consider: Nonclinical Research and Development of In Vivo Gene Therapy Products, Emphasizing Adeno-Associated Virus Vectors.
Toxicol Pathol
; 50(1): 118-146, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34657529
2.
The Natural History of Pneumonic Tularemia in Female Fischer 344 Rats after Inhalational Exposure to Aerosolized Francisella tularensis Subspecies tularensis Strain SCHU S4.
Am J Pathol
; 187(2): 252-267, 2017 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-27939130
3.
Lethal factor, but not edema factor, is required to cause fatal anthrax in cynomolgus macaques after pulmonary spore challenge.
Am J Pathol
; 184(12): 3205-16, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25285720
4.
Local and systemic tolerability of a 2'O-methoxyethyl antisense oligonucleotide targeting interleukin-4 receptor-α delivery by inhalation in mouse and monkey.
Inhal Toxicol
; 26(8): 452-63, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24932560
5.
Preclinical safety and biodistribution assessment of Ad-KCNH2-G628S administered via atrial painting in New Zealand white rabbits.
Basic Clin Pharmacol Toxicol
; 133(2): 179-193, 2023 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-37177881
6.
Expression of either lethal toxin or edema toxin by Bacillus anthracis is sufficient for virulence in a rabbit model of inhalational anthrax.
Infect Immun
; 80(7): 2414-25, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22526673
7.
Antibodies contribute to effective vaccination against respiratory infection by type A Francisella tularensis strains.
Infect Immun
; 79(4): 1770-8, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21282410
8.
Identification of an Attenuated Substrain of Francisella tularensis SCHU S4 by Phenotypic and Genotypic Analyses.
Pathogens
; 10(6)2021 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34067337
9.
Chromatin remodeling by the histone methyltransferase EZH2 drives lung pre-malignancy and is a target for cancer prevention.
Clin Epigenetics
; 13(1): 44, 2021 02 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33632299
10.
Granuloma formation induced by low-dose chronic silica inhalation is associated with an anti-apoptotic response in Lewis rats.
J Toxicol Environ Health A
; 73(10): 669-83, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-20391111
11.
Gene promoter hypermethylation in mouse lung tumors.
Mol Cancer Res
; 4(4): 267-73, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16603640
12.
Preclinical efficacy and safety of KCNH2-G628S gene therapy for postoperative atrial fibrillation.
J Thorac Cardiovasc Surg
; 154(5): 1644-1651.e8, 2017 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28676183
13.
Aberrant promoter hypermethylation of the death-associated protein kinase gene is early and frequent in murine lung tumors induced by cigarette smoke and tobacco carcinogens.
Cancer Res
; 64(11): 3844-8, 2004 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15172992
14.
Safety and biodistribution assessment of sc-rAAV2.5IL-1Ra administered via intra-articular injection in a mono-iodoacetate-induced osteoarthritis rat model.
Mol Ther Methods Clin Dev
; 3: 15052, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26817025
15.
The toxicity of microcystin LR in mice following 7 days of inhalation exposure.
Toxicon
; 45(6): 691-8, 2005 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15804518
16.
Oncostatin M induces growth arrest of mammary epithelium via a CCAAT/enhancer-binding protein delta-dependent pathway.
Mol Cancer Ther
; 1(8): 601-10, 2002 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12479220
17.
Immunization with a Recombinant, Pseudomonas fluorescens-Expressed, Mutant Form of Bacillus anthracis-Derived Protective Antigen Protects Rabbits from Anthrax Infection.
PLoS One
; 10(7): e0130952, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26207820
18.
Intrapleural administration of an AAVrh.10 vector coding for human α1-antitrypsin for the treatment of α1-antitrypsin deficiency.
Hum Gene Ther Clin Dev
; 24(4): 161-73, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24191907
19.
Preclinical evaluation of a recombinant adeno-associated virus vector expressing human alpha-1 antitrypsin made using a recombinant herpes simplex virus production method.
Hum Gene Ther
; 22(2): 155-65, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20812844
20.
Cowpox virus inhibits human dendritic cell immune function by nonlethal, nonproductive infection.
Virology
; 412(2): 411-25, 2011 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-21334039