Detalhe da pesquisa
1.
Exploration of a Large Virtual Chemical Space: Identification of Potent Inhibitors of Lactate Dehydrogenase-A against Pancreatic Cancer.
J Chem Inf Model
; 63(3): 1028-1043, 2023 02 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36646658
2.
Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure-activity relationship, in vitro and in vivo evaluation as antitumor agents.
Bioorg Med Chem Lett
; 41: 127923, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33705908
3.
The 3-D conformational shape of N-naphthyl-cyclopenta[d]pyrimidines affects their potency as microtubule targeting agents and their antitumor activity.
Bioorg Med Chem
; 29: 115887, 2021 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33310545
4.
Interleukin (IL)-6 modulates transforming growth factor-ß receptor I and II (TGF-ßRI and II) function in epidermal keratinocytes.
Exp Dermatol
; 26(8): 697-704, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27892604
5.
Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.
Bioorg Med Chem Lett
; 27(7): 1602-1607, 2017 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28258797
6.
Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents.
Bioorg Med Chem
; 25(2): 545-556, 2017 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27894589
7.
A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial-associated necrosis in breast cancer.
J Pharmacol Exp Ther
; 353(2): 392-404, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25720766
8.
Identification of novel drugs to target dormant micrometastases.
BMC Cancer
; 15: 404, 2015 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-25971923
9.
Evaluation of 99mTc-probestin for imaging APN expressing tumors by SPECT.
Bioorg Med Chem Lett
; 23(18): 5049-52, 2013 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23937983
10.
Solid phase synthesis and biological evaluation of probestin as an angiogenesis inhibitor.
Bioorg Med Chem Lett
; 23(12): 3561-4, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23664876
11.
N2-Trimethylacetyl substituted and unsubstituted-N4-phenylsubstituted-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines: design, cellular receptor tyrosine kinase inhibitory activities and in vivo evaluation as antiangiogenic, antimetastatic and antitumor agents.
Bioorg Med Chem
; 21(5): 1312-23, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23375090
12.
Synthesis and biological activity of 5-chloro-N4-substituted phenyl-9H-pyrimido[4,5-b]indole-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic agents.
Bioorg Med Chem
; 21(7): 1857-64, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23434139
13.
Synthesis and evaluation of novel Tc-99m labeled probestin conjugates for imaging APN/CD13 expression in vivo.
Bioconjug Chem
; 23(1): 115-24, 2012 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-22148582
14.
Synthesis and biodistribution studies of technetium-99m-labeled aminopeptidase N inhibitor conjugates.
Bioorg Med Chem Lett
; 22(14): 4567-70, 2012 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22727671
15.
N4-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: design, synthesis, and in vivo evaluation.
Bioorg Med Chem
; 20(7): 2444-54, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22370340
16.
N4-Aryl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as receptor tyrosine kinase inhibitors.
Bioorg Med Chem
; 20(2): 910-4, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22204741
17.
Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents.
Bioorg Med Chem
; 20(14): 4217-25, 2012 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22739090
18.
TNF-Alpha as an Initiator of Allodynia and Anxiety-Like Behaviors in a Preclinical Model of PTSD and Comorbid Pain.
Front Psychiatry
; 12: 721999, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34512420
19.
The contribution of a 2-amino group on receptor tyrosine kinase inhibition and antiangiogenic activity in 4-anilinosubstituted pyrrolo[2,3-d]pyrimidines.
Bioorg Med Chem Lett
; 20(10): 3177-81, 2010 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20403693
20.
Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents.
Bioorg Med Chem
; 18(10): 3575-87, 2010 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20403700