RESUMO
Behçet's disease (BD) is a systemic inflammatory disease commonly characterized by oral and genital ulcerations, with skin and eye involvement. Its cause is still unknown, but vasculitis is the major pathologic feature. BD is a rare condition, seen more commonly in Turkey, as well as in Middle Eastern, Mediterranean and Far Eastern countries. Neurological involvement is reported to manifest as brainstem or corticospinal tract syndromes, increased intracranial pressure mostly related to venous sinus thrombosis or aseptic meningitis, isolated behavioral symptoms or isolated headache. This report presents a 34-year-old BD patient with secondary cerebral infarction due to head trauma. The clinical and central nervous system findings of BD are discussed.
Assuntos
Transtornos Cerebrovasculares/complicações , Artéria Cerebral Média/fisiopatologia , Espondilite Anquilosante/complicações , Espondilite Anquilosante/patologia , Adulto , Lateralidade Funcional/fisiologia , Humanos , Imageamento por Ressonância Magnética/métodos , Masculino , Tomografia Computadorizada por Raios X/métodosRESUMO
INTRODUCTION: The aim of the present study was to evaluate the role of erythropoietin (EPO) in liver and renal injury following hemorrhagic shock (HS) after inhibition of tyrosine kinase activity in rats.. METHODS: Forty-eight Sprague-Dawley rats were assigned to six groups: (I) HS alone; (II) HS followed by retransfusion; (III) EPO and genistein followed by HS; (IV) EPO and genistein followed by HS, followed by retransfusion; (V) HS followed by EPO and genistein; and (VI) HS followed by EPO and genistein, followed by retransfusion. HS was induced for 60 minutes after withdrawal of 30% of the calculated total blood volume of each rat from the left femoral artery. Blood and tissue samples (from the kidney and liver) were obtained 60 minutes after HS in Group I, III, and V; blood and tissue samples were obtained 60 minutes after retransfusion in Group II, IV, and VI. In Group III and IV, EPO was given 60 minutes before HS, and genistein 30 minutes before HS. In Group V and VI, EPO and genistein were given 30 minutes after HS. RESULTS: Liver and renal injury were significantly attenuated with EPO and genistein administration. CONCLUSION: These results suggest that EPO is effective in attenuating liver and renal injury in HS, even with inhibition of tyrosine kinase activity with genistein.
Assuntos
Eritropoetina/farmacologia , Nefropatias/prevenção & controle , Hepatopatias/prevenção & controle , Choque Hemorrágico/complicações , Animais , Linfócitos T CD4-Positivos/patologia , Linfócitos T CD8-Positivos/patologia , Genisteína/farmacologia , Interleucina-2/análise , Rim/imunologia , Rim/patologia , Nefropatias/etiologia , Nefropatias/patologia , Fígado/imunologia , Fígado/patologia , Hepatopatias/etiologia , Hepatopatias/patologia , Masculino , Proteínas Tirosina Quinases/antagonistas & inibidores , Ratos , Ratos Sprague-Dawley , Fator de Necrose Tumoral alfa/análiseRESUMO
BACKGROUND: It is unclear whether hemostasis plays a role in the pathogenesis of ischemic stroke subtypes. OBJECTIVE: We aimed to investigate the possible relationship between different hemostatic markers and lacunar stroke. RESULTS: The study consisted of 30 patients with symptomatic lacunar stroke and 30 healthy age-matched healthy individuals. We analyzed the values of "Mean Platelet Volume," D-dimer, "soluble p-selectin," "Plasminogen Activator Inhibitor Type-1" (PAI-1), "Thrombin-Activatable Fibrinolysis Inhibitor" (TAFI), and "Platelet Factor 4" (PF4) in patients with lacunar infarct and compared these values to those of control individuals. There were significant differences for D-dimer, mean platelet volume, thrombin-activatable fibrinolysis inhibitor, and platelet factor 4 values in symptomatic lacunar stroke group compared with the control group (P < 0.01). CONCLUSIONS: Different hemostatic factors may play a role in the pathogenesis of lacunar stroke. Evaluating the role of hemostatic factors on different types of strokes may help us identify new therapeutic strategies and different prognostic stratifications for ischemic stroke.
Assuntos
Transtornos da Coagulação Sanguínea/sangue , Infarto Encefálico/sangue , Infarto Encefálico/fisiopatologia , Isquemia Encefálica/sangue , Isquemia Encefálica/fisiopatologia , Hemostasia/fisiologia , Idoso , Idoso de 80 Anos ou mais , Biomarcadores/análise , Biomarcadores/sangue , Transtornos da Coagulação Sanguínea/diagnóstico , Infarto Encefálico/diagnóstico , Isquemia Encefálica/diagnóstico , Carboxipeptidase B2/análise , Carboxipeptidase B2/sangue , Feminino , Produtos de Degradação da Fibrina e do Fibrinogênio/análise , Produtos de Degradação da Fibrina e do Fibrinogênio/metabolismo , Humanos , Masculino , Pessoa de Meia-Idade , Selectina-P/análise , Selectina-P/sangue , Inibidor 1 de Ativador de Plasminogênio/análise , Inibidor 1 de Ativador de Plasminogênio/sangue , Ativação Plaquetária/fisiologia , Fator Plaquetário 4/análise , Fator Plaquetário 4/sangue , Valor Preditivo dos Testes , PrognósticoRESUMO
Osteopoikilosis is a rare, usually asymptomatic, autosomal dominant bone disorder, which is usually found incidentally on X-ray. Klippel-Feil syndrome is a rare disorder characterized by the congenital fusion of any two of the seven cervical (neck) vertebrae. It is caused by a failure in the normal segmentation or division of the cervical vertebrae during the early weeks of fetal development. In this case report, we describe a woman with osteopoikilosis associated with type 2 Klippel-Feil syndrome. Additionally, four female members of her family had osteopoikilosis. We state that possible syndromes that can go with osteopoikilosis must be kept in mind in case of an incidental diagnosis in daily practice.