RESUMO
PURPOSE: Early-life stress (ELS) may mediate adjustment problems while resilience may protect individuals against adjustment problems during military service. We investigated the relationship of ELS and resilience with adjustment problem factor scores in the Korea Military Personality Test (KMPT) in candidates for the military service. METHODS: Four hundred and sixty-one candidates participated in this study. Vulnerability traits for military adjustment, ELS, and resilience were assessed using the KMPT, the Korean Early-Life Abuse Experience Questionnaire, and the Resilience Quotient Test, respectively. Data were analyzed using multiple linear regression analyses. RESULTS: The final model of the multiple linear regression analyses explained 30.2 % of the total variances of the sum of the adjustment problem factor scores of the KMPT. Neglect and exposure to domestic violence had a positive association with the total adjustment problem factor scores of the KMPT, but emotion control, impulse control, and optimism factor scores as well as education and occupational status were inversely associated with the total military adjustment problem score. CONCLUSIONS: ELS and resilience are important modulating factors in adjusting to military service. We suggest that neglect and exposure to domestic violence during early life may increase problem with adjustment, but capacity to control emotion and impulse as well as optimistic attitude may play protective roles in adjustment to military life. The screening procedures for ELS and the development of psychological interventions may be helpful for young adults to adjust to military service.
Assuntos
Adaptação Psicológica , Violência Doméstica/psicologia , Militares/psicologia , Resiliência Psicológica , Transtornos de Estresse Pós-Traumáticos/psicologia , Adolescente , Adulto , Criança , Violência Doméstica/estatística & dados numéricos , Feminino , Humanos , Coreia (Geográfico) , Acontecimentos que Mudam a Vida , Masculino , Testes de Personalidade , Estudos Retrospectivos , Fatores Socioeconômicos , Inquéritos e Questionários , Adulto JovemRESUMO
Previous studies have reported a relationship between short sleep duration and childhood overweight. Although school-aged children tend to compensate for weekday sleep deficit by increasing weekend sleep duration, the association between weekend catch-up sleep and childhood overweight remains unclear. This study aimed to examine the relationship between weekend catch-up sleep and being overweight in children. A total of 936 school children (48.2% boys) aged 10 or 11 years participated in this school-based cohort study. Anthropometric measurements including height and body weight were carried out. We obtained data on sleep patterns, lifestyle and parent characteristics using questionnaires. The main outcome measure was childhood overweight. After adjusting for the relevant confounding variables (age, sex, breakfast eating, screen time and parental obesity), longer sleep on weekdays and weekends was associated with decreased odds of childhood overweight (OR: 0.68; 95% CI: 0.54-0.86; OR: 0.64; 95% CI: 0.53-0.77, respectively). Participants with increased catch-up sleep duration during weekends also had decreased odds of being overweight (OR: 0.67; 95% CI: 0.53-0.85). There was an interaction between weekday sleep duration and weekend catch-up sleep in relation to childhood overweight, and this effect of weekend catch-up sleep on being overweight was stronger as the participants slept less on weekdays (P = 0.024). These results indicate that weekend catch-up sleep is independently associated with decreased risk of being overweight in fifth-grade students, and this effect can be varied by the weekday sleep duration. A prospective study is required to confirm this observation.
Assuntos
Sobrepeso/prevenção & controle , Sobrepeso/fisiopatologia , Privação do Sono/prevenção & controle , Privação do Sono/fisiopatologia , Sono/fisiologia , Adulto , Desjejum , Criança , Feminino , Humanos , Masculino , Obesidade/fisiopatologia , Obesidade/prevenção & controle , Razão de Chances , Pais , Inquéritos e QuestionáriosRESUMO
OBJECTIVE: This study explored the clinical characteristics and risk factors of suicidal ideation in a sample of first graders from South Korea. Children's depression and aggression and maternal depression were examined as possible risk factors. METHODS: This study is a school-based, cross-sectional study of 5 elementary schools in Gunpo City, South Korea. Participants were 707 first graders (mean age, 6.54 years) and their mothers. We assessed children's depressive and aggressive symptoms using the Behavior Assessment System for Children-2 (BASC-2) and maternal depression using the Beck Depression Inventory (BDI). Two items from BASC-2 and 1 item from BDI identified children's and maternal suicidal ideation. RESULTS: Twenty-seven (3.8%) children evidenced suicidal ideation. Children with suicidal ideation had higher mean scores of depression domain (10.11 ± 5.34 vs 4.57 ± 3.44, P < .0001) and aggression domain (7.78 ± 3.84 vs 3.80 ± 2.85, P < .0001) on BASC-2 and maternal depression (9.78 ± 6.45 vs 7.28 ± 5.38, P = .02) on BDI. In regression analysis, children's depression (odds ratio [OR], 1.19; 95% confidence interval [CI], 1.07-1.32; P = .001) and aggression (OR, 1.24; 95% CI, 1.08-1.41; P = .002) contributed significantly to children's suicidal ideation, whereas maternal depression was not significantly related to children's suicidal ideation (OR, 0.99; 95% CI, 0.92-1.06; P = .75). CONCLUSIONS: This study demonstrated that even first graders had a considerable prevalence of suicidal ideation and that depression and aggression were associated with suicidal ideation in young children.
Assuntos
Agressão/psicologia , Transtorno Depressivo/epidemiologia , Transtorno Depressivo/psicologia , Ideação Suicida , Adulto , Criança , Estudos Transversais , Transtorno Depressivo/diagnóstico , Feminino , Inquéritos Epidemiológicos , Humanos , Masculino , Mães/psicologia , Determinação da Personalidade/estatística & dados numéricos , Psicometria , República da Coreia , Fatores de RiscoRESUMO
BACKGROUND: The number of workers who died due to occupational injury in Korea as of 2007 was 1,383. The aim of this study was to identify whether there were any differences in the risk of occupational injury between nonstandard workers (temporary workers and/or subcontract workers) and regular workers. METHODS: 1,576 injured workers, selected from National Health Insurance and National Workers' Compensation Insurance, were interviewed via telephone survey using standardized questionnaires in 2007. The control group was 1,500 workers matched for age, gender, and severity of injury. A multivariate logistic regression model was used to analyze the association between the type of nonstandard work and occupational injury. RESULTS: Nonstandard temporary workers were more likely to be injured than regular workers even if other related factors of occupational injury were statistically adjusted (adjusted odds ratio, OR 2.87, 95% confidence interval 2.37-3.49). CONCLUSIONS: The reason why the risks of nonstandard workers are higher than those of regular workers is that nonstandard workers are placed in poor working conditions.
Assuntos
Acidentes de Trabalho/estatística & dados numéricos , Doenças Profissionais/epidemiologia , Exposição Ocupacional/efeitos adversos , Ferimentos e Lesões/epidemiologia , Adulto , Estudos de Casos e Controles , Intervalos de Confiança , Bases de Dados Factuais , Feminino , Inquéritos Epidemiológicos , Humanos , Incidência , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Doenças Profissionais/etiologia , Razão de Chances , República da Coreia/epidemiologia , Medição de Risco/métodos , Ferimentos e Lesões/etiologia , Adulto JovemRESUMO
BACKGROUND: Distal radioulnar joint (DRUJ) instability is an important cause of ulnar-sided wrist pain in distal radius fractures. However, instability is frequently undiagnosed and the clinical and radiographic factors associated with instability are not well understood. QUESTIONS/PURPOSES: We therefore identified clinical and radiographic factors associated with DRUJ instability in distal radius fractures. PATIENTS AND METHODS: We retrospectively reviewed all 221 patients who underwent surgical treatment for unstable distal radius fractures from 2007 to 2010. Ten patients (five men and five women) had DRUJ instability by intraoperative manual testing (Group I); these patients had a median age of 52 years. The other 211 patients (81 men and 130 women) (Group II) had a median age of 55 years. Clinical and radiographic data were compared between the groups. RESULTS: The incidence of open wounds at the wrist and the relative ulnar length measured on the prereduction radiograph were greater in Group I. An open wound at the wrist and positive ulnar variance of 6 mm or greater on the prereduction radiograph increased the risk of DRUJ instability (relative risks = 45 and 17, respectively) in distal radius fractures. CONCLUSIONS: An open wound at the wrist or positive ulnar variance of 6 mm or greater observed on the prereduction radiograph in patients with distal radius fractures should alert the physician to the possibility of DRUJ instability. LEVEL OF EVIDENCE: Level II, prognostic study. See the Guidelines for Authors for a complete description of levels of evidence.
Assuntos
Fraturas Expostas/complicações , Instabilidade Articular/diagnóstico , Fraturas do Rádio/diagnóstico por imagem , Ulna/diagnóstico por imagem , Articulação do Punho/diagnóstico por imagem , Adulto , Feminino , Humanos , Instabilidade Articular/diagnóstico por imagem , Instabilidade Articular/etiologia , Masculino , Pessoa de Meia-Idade , Radiografia , Fraturas do Rádio/complicações , Fraturas do Rádio/diagnóstico , Fraturas do Rádio/cirurgia , Estudos RetrospectivosRESUMO
BACKGROUND: Pattern-induced visual discomfort and photophobia are frequently observed symptoms in migraineurs. The presumed pathophysiologic mechanisms of pattern glare and photophobia seem to overlap anatomically within the central nervous system. OBJECTIVE: To assess the relationship between interictal pattern-induced visual discomfort and ictal photophobia in episodic migraineurs. METHODS: We compared pattern-induced visual discomfort among 3 groups: controls, migraineurs without ictal photophobia (MwoP), and migraineurs with ictal photophobia (MwP). Photophobia was assessed with a validated photophobia questionnaire. Visual discomfort tests were performed using 3 striped patterns with different spatial frequencies. After viewing the patterns for 10 seconds, subjects were asked to report the severity of visual discomfort using 4 scales (none, mild, moderate, and severe) and using a 0-10 visual analog scale (VAS). We compared the proportion of subjects choosing moderate-to-severe discomfort and the median values of VAS scores for each pattern among the 3 groups. RESULTS: We enrolled 35 controls, 18 MwoP, and 44 MwP, and there were no significant differences in clinical features among the 3 groups. MwP reported a significantly higher proportion of moderate-to-severe discomfort and higher median VAS scores than the controls and MwoP did. The intensity of discomfort increased with higher frequency of visual stimuli. CONCLUSIONS: We conclude that MwP experienced more severe pattern-induced visual discomfort as compared with the controls and MwoP.
Assuntos
Dor Ocular/fisiopatologia , Transtornos de Enxaqueca/fisiopatologia , Reconhecimento Visual de Modelos , Estimulação Luminosa , Fotofobia/fisiopatologia , Adulto , Dor Ocular/epidemiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Transtornos de Enxaqueca/epidemiologia , Medição da Dor , Fotofobia/epidemiologiaRESUMO
During warfarin treatment, determining the optimal dose and maintaining the target PT-INR are challenging. Increasing evidence supports the theory that genotypic polymorphisms influence an individual's warfarin dose requirement. In this study, we evaluated allele frequencies and effects of CYP2C9 and VKORC1 on warfarin response during initial anticoagulation therapy in Korean patients. We enrolled patients who had initiated warfarin therapy and undergone PT-INR testing at least three times within the first month of anticoagulation therapy. All the participating patients were tested for the detection of CYP2C9*3 (c.1075A>C) and VKORC1-1639G>A. A melting-curve analysis after real-time PCR was performed using CYP2C9*3 and VK1639 genotyping kits (Idaho Technology, US). A total of 37 patients were enrolled in this study. CYP2C9*1/*1 (87%) and VKORC1-1639AA genotypes (89%) were predominant in Korea. The CYP2C9*3 and VKORC1-1639G alleles were found in five (13%) and four patients (11%), respectively. Patients with the CYP2C9*3 allele received a lower warfarin dose (P = 0.018) and tended to show more rapid PT-INR increase than CYP2C9*1/*1 genotype. Patients with the VKORC1-1639G allele nonsignificantly received higher warfarin dose than those without. The CYP2C9*3 and VKORC1-1639G alleles influenced warfarin response during the first month of anticoagulation therapy. Considering these results, CYP2C9 and VKORC1 genotyping can be an useful tool to estimate initial warfarin dose and frequency of PT-INR monitoring during the first month of anticoagulation therapy.
Assuntos
Anticoagulantes/uso terapêutico , Polimorfismo Genético , Varfarina/farmacologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Hidrocarboneto de Aril Hidroxilases/genética , Citocromo P-450 CYP2C9 , Relação Dose-Resposta a Droga , Monitoramento de Medicamentos , Feminino , Frequência do Gene , Genótipo , Humanos , Coeficiente Internacional Normatizado , Coreia (Geográfico) , Masculino , Pessoa de Meia-Idade , Oxigenases de Função Mista/genética , Farmacogenética/métodos , Vitamina K Epóxido Redutases , Varfarina/uso terapêuticoRESUMO
OBJECTIVE: To determine whether spouses who only smoke cigarettes outside the home can reduce the secondhand smoke (SHS) exposure of non-smoking pregnant women to the levels of those with non-smoking spouses. METHODS: In this cross-sectional survey performed between 1 October 2006 and 31 July 2007, 896 non-smoking pregnant women in their 35th gestational week were included. Hair nicotine levels and the smoking behaviour of their spouses at home were assessed. RESULTS: The geometric means of the hair nicotine levels of the participants with non-smoking spouses (group A), the participants with spouses who only smoked outside the home (group B), and the participants with spouses who smoked inside the home (group C) were 0.33 ng/mg (95% CI 0.30 to 0.35), 0.51 ng/mg (95% CI, 0.45 to 0.57) and 0.58 ng/mg (95% CI, 0.51 to 0.65), respectively. The mean log hair nicotine level of group A was significantly different from the other groups (p<0.001, Scheffe's post hoc test). Multiple linear regression analysis of the log-transformed hair nicotine levels of the participants after adjusting for confounding showed that the mean differences (SE of the mean difference) of groups B and C compared to the reference group A were 0.43 (0.07; p<0.001) and 0.44 (0.10; p<0.001), respectively. CONCLUSIONS: Spouses who only smoked outside the home did not reduce the level of SHS exposure of pregnant women to the level of pregnant women with non-smoking spouses. A strategy based on the separation of pregnant women and the smoking activity of their spouses might be inadequate to protect pregnant women from SHS at home.
Assuntos
Cabelo/química , Habitação , Nicotina/análise , Fumar/psicologia , Cônjuges/psicologia , Poluição por Fumaça de Tabaco/análise , Adulto , Estudos Transversais , Feminino , Humanos , Masculino , Gravidez , Poluição por Fumaça de Tabaco/estatística & dados numéricosRESUMO
OBJECTIVE: To analyze the relationship between serum prostate-specific antigen (PSA) and body mass index (BMI) according to age in a population of ostensibly healthy Korean men. PATIENTS AND METHODS: Between 2002 and 2006, data from 13,025 men who visited health promotion centers were evaluated. All men underwent anthropometric measurements and serum PSA determination. The relationship between serum PSA and BMI according to age was analyzed. RESULTS: The median age was 50.0 years and the median serum PSA level was 0.69 ng/ml. There was no relationship between serum PSA and BMI in the group whose BMI was <23 kg/m(2). The serum PSA showed a significant inverse relationship in those with BMI of ≥23 kg/m(2). However, this finding was only true among 40- to 59-year-old middle aged men and no such relationship between serum PSA and BMI was seen in the older groups (60-79 years of age). CONCLUSION: Our study revealed serum PSA had a significant inverse relationship with BMI in overweight and obese men aged between 40 and 59 years; however, there was no relationship between serum PSA and BMI in men whose age was older than 60 years.
Assuntos
Povo Asiático , Índice de Massa Corporal , Obesidade/sangue , Obesidade/etnologia , Sobrepeso/sangue , Sobrepeso/etnologia , Antígeno Prostático Específico/sangue , Adulto , Distribuição por Idade , Fatores Etários , Idoso , Regulação para Baixo , Humanos , Masculino , Pessoa de Meia-Idade , República da CoreiaRESUMO
BACKGROUND: Cytochrome P450 2E1 (CYP2E1) and NAD(P)H:quinone oxidoreductase (NQO1) catalyze the activation of some environmental procarcinogens present in tobacco smoke (i.e. nitrosoamines and heterocyclic amines). We conducted a hospital based case-control study to evaluate the potential association between genetic polymorphisms of CYP2E1 (C1019T in the 5' flanking region) and NQO1 (C609T in exon 6) and bladder cancer risk in Asian population. METHODS: The study population was comprised of 218 histologically confirmed prevalent bladder cancer cases and 199 controls without cancer or systemic illness. PCR-restriction fragment length polymorphism based methods were used for the genotyping analyses and unconditional logistic regression model for the statistical evaluations. RESULTS: The risk of bladder cancer increased with the amount of smoking (P for trend < 0.01). The frequency of CYP2E1 c1/c1 genotype was significantly higher in bladder cancer patients (57.9%) than in the controls (47.9%) (OR = 1.8, 95% CI = 1.1-2.9). Similarly, the NQO1 C/C genotypes were significantly more prevalent in the patients (45.8%) than in the controls (37.6%) (OR = 1.6, 95% CI = 1.0-2.7). The risk for bladder cancer increased with the number of the putative risk genotypes (P for trend = 0.03); the most remarkable risk was observed for heavy smokers with both CYP2E1 c1/c1 and NQO1 C/C genotypes (OR = 13.8, 95% CI = 3.9-48.6) when compared to non/light smokers with other genotypes. CONCLUSION: Our findings suggest that CYP2E1 and NQO1 genotypes may play an important role in development of smoking related bladder cancer among Korean men.
Assuntos
Citocromo P-450 CYP2E1/genética , NAD(P)H Desidrogenase (Quinona)/genética , Fumar , Neoplasias da Bexiga Urinária/etiologia , Neoplasias da Bexiga Urinária/genética , Povo Asiático/genética , Feminino , Predisposição Genética para Doença , Genótipo , Humanos , MasculinoRESUMO
OBJECTIVES: Long working hours can negatively impact a worker's health. The objective of this study was to examine the association between working hours and cardiovascular diseases (CVDs) and compare the degree of risk based on CVD subtypes in Korean workers. METHODS: This study was a case-control study of the patients registered in the Occupational Cardiovascular Diseases Surveillance 2010. The cases included 348 patients diagnosed with a CVD (123 cerebral infarction, 69 intracerebral hemorrhage, 57 subarachnoid hemorrhage, 99 acute myocardial infarction). Controls were 769 participants with no history of CVDs matched for gender, age, type of occupation, and region. Participants' working hours in the previous week and the average working hours over the past three months were assessed to examine short-term and long-term effects. RESULTS: After adjusting for confounding factors, the odds ratios (ORs) for CVDs in the short-term were 2.66 (95% Confidence interval (CI) :1.78-3.99) for working ≤40 hours, 1.85 (95% CI: 1.22-2.81) for working 50.1-60 hours and 4.23 (95% CI: 2.81-6.39) for working >60 hours compared with the 40.1-50-hour working group. The ORs in the long-term were 2.90 (95% CI: 1.86-4.52) for working ≤40 hours, 1.73 (95% CI: 1.03-2.90) for working 48.1-52 hours and 3.46 (95% CI: 2.38-5.03) for working >52 hours compared with the 40.1-48-hour working group. CONCLUSIONS: Long working hours are related to an increased risk of CVDs, and the degree of risk differs based on CVD subtype. Short working hours are also related to an increased risk for CVDs. More prospective studies targeting specific disease risks are required.
Assuntos
Doenças Cardiovasculares/etiologia , Admissão e Escalonamento de Pessoal/estatística & dados numéricos , Tolerância ao Trabalho Programado/fisiologia , Doenças Cardiovasculares/epidemiologia , Estudos de Casos e Controles , Feminino , Humanos , Incidência , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Doenças Profissionais/epidemiologia , Doenças Profissionais/etiologia , Vigilância da População/métodos , Estudos Prospectivos , República da Coreia/epidemiologia , Fatores de Risco , Fatores de Tempo , Tolerância ao Trabalho Programado/psicologiaRESUMO
BACKGROUND: The ideal points for medial patellofemoral ligament (MPFL) reconstruction have not been precisely defined. PURPOSE: To determine at which flexion angles the grafts should be fixed to best restore patellar stability as well as to compare the length change of various femoral and patellar fixation sites for current MPFL reconstruction during knee flexion in vivo. STUDY DESIGN: Descriptive laboratory study. METHODS: The right knees of 10 living patients were scanned with a high-resolution computed tomography scanner at 0°, 30°, 60°, 90°, and 120° of knee flexion, and 3-dimensional knee models were constructed using customized software. Based on recent anatomic studies and current surgical techniques, 4 femoral points (A: adductor tubercle; B: midpoint between the medial epicondyle and the adductor tubercle; C: medial epicondyle; and D: 10 mm inferior to the adductor tubercle) and 2 patellar points (30% [point 1] and 45% [point 2] from the proximal pole of the patella) were marked. The lengths of the 8 ligaments were digitally measured, and the length changes of these ligaments at the 5 different knee flexion angles were calculated. RESULTS: Two ligaments including the adductor tubercle (A1, A2) showed an increase while the knee was flexed over 60°. Four ligaments (B1, B2, D1, D2) showed a slight increase as the knee flexed from 0° to 30° and a decrease as the flexion angle exceeded 30°. Length changes in these 6 ligaments were not significantly different. There was no significant difference between 2 patellar points in the length changes of these 6 ligaments. Two ligaments including the medial epicondyle (C1, C2) showed an excessive decrease during knee flexion and showed greatest length changes. CONCLUSION: The femoral fixation sites should be located at point B or point D. Point A and point C are not ideal femoral fixation sites. The best angle for graft fixation would be near 30° of knee flexion. CLINICAL RELEVANCE: The data obtained for length and length change pattern in each virtual ligament will serve as a useful basis for improved MPFL reconstruction.
Assuntos
Fêmur/cirurgia , Instabilidade Articular/prevenção & controle , Articulação do Joelho/diagnóstico por imagem , Ligamentos/diagnóstico por imagem , Patela/cirurgia , Adulto , Humanos , Articulação do Joelho/cirurgia , Masculino , Modelos Biológicos , Procedimentos Ortopédicos , Amplitude de Movimento Articular , Procedimentos de Cirurgia Plástica , Tomografia Computadorizada por Raios XRESUMO
OBJECTIVES: This study was performed to determine whether there is an association between impaired fasting glucose and noise-induced hearing loss. METHODS: The study subjects were workers in one automobile manufacturing company. The data were obtained from results of health examinations during 2005 and 2009. The factors analyzed were age, smoking and alcohol history, work duration, environmental noise level, hearing thresholds, blood pressure, serum creatinine, initial hearing threshold and fasting glucose. RESULTS: The hearing thresholds at 4,000 Hz frequencies for both ears were significantly higher in 2009 than those in 2005. The changes in the hearing thresholds of the subjects with an impaired fasting glucose (100-125 mg/dl) and diabetes (≥126 mg/dl) were greater than those of the normal (<100 mg/dl) group. After adjusting for variables such as age, smoking and alcohol history, environmental noise, hypertension and serum creatinine, fasting glucose was found to be a significant variable. Impaired fasting glucose (100-125 mg/dl) was significant (ß=1.339, p=0.002) for the right ear, whereas it was not significant (ß=0.639, p=0.121) for the left ear. CONCLUSIONS: Impaired fasting glucose, as well as diabetes, might be risk factors for hearing loss in individuals with exposure to certain noise levels. The results of this study suggest that impaired fasting glucose should be considered a risk factor for hearing loss.
Assuntos
Automóveis , Intolerância à Glucose/complicações , Perda Auditiva Provocada por Ruído/complicações , Ruído Ocupacional/efeitos adversos , Doenças Profissionais/complicações , Adulto , Glicemia/metabolismo , Distribuição de Qui-Quadrado , Complicações do Diabetes/sangue , Jejum , Perda Auditiva Provocada por Ruído/sangue , Humanos , Masculino , Pessoa de Meia-Idade , Doenças Profissionais/sangue , Estudos Retrospectivos , Estatísticas não ParamétricasRESUMO
INTRODUCTION: Prediction of lymph node metastasis in early gastric cancer (EGC) is very important to decide treatment strategies preoperatively. The aim of this study was to evaluate factors that predict the presence of lymph node metastasis and to identify the differences between mucosal and submucosal gastric cancers. METHODS: A total of 376 patients with EGC who underwent gastrectomy from March 1999 through December 2007 were retrospectively identified. The clinopathological factors and biological markers (p53, Ki67) were analyzed. RESULTS: The rate of lymph node metastasis was 9.6% (mucosal cancer 2.8%, submucosal cancer 18.4%). Tumor size, depth of invasion, macroscopic type, and lymphovascular invasion were related to lymph node metastasis in EGC. When the carcinomas were confined to the mucosal layer, tumor size and lymphovascular invasion showed significant correlation with lymph node metastasis. On the other side, macroscopic type and lymphovascular invasion were association with lymph node metastasis in submucosal carcinoma. CONCLUSION: The risk factors for lymph node metastasis in EGC are quite different depending on depth of tumor invasion. To predict lymph node metastasis in EGC, it is recommended that distinct assessment according to individual situation should be clearly established.
Assuntos
Carcinoma/secundário , Neoplasias Gástricas/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Carcinoma/metabolismo , Carcinoma/terapia , Feminino , Mucosa Gástrica/patologia , Humanos , Antígeno Ki-67/metabolismo , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Invasividade Neoplásica , Estudos Retrospectivos , Fatores de Risco , Neoplasias Gástricas/metabolismo , Neoplasias Gástricas/terapia , Proteína Supressora de Tumor p53/metabolismoRESUMO
PURPOSE: We aimed to verify the current status of transurethral resection of the prostate (TURP) in Korea. MATERIALS AND METHODS: The medical records of 1,341 men who underwent TURP in 9 Korean medical centers between 2004 and 2008 were reviewed. The patients were divided into two groups according to time periods: 2004-2005 (group 1) and 2006-2008 (group 2). To verify differences in the two patient groups, age, prostate volume, indications for TURP, preoperative International Prostate Symptom Score (IPSS), and resected tissue weight were evaluated. RESULTS: The mean age of the patients was 71.2 years and the mean IPSS was 22.7. The patients' characteristics were not significantly different between the two groups. The annual cases of TURP increased over the study period. The proportion of lower urinary tract symptoms (LUTS) as an indication for TURP increased up to 58.3% in group 2 compared with 51.6% in group 1 (p=0.019). However, the proportion of patients who presented with acute urinary retention decreased from 35.5% to 30.3% with marginal statistical significance (p=0.051). Other indications such as hematuria, bladder stone, recurrent urinary tract infection, and hydronephrosis were not significantly different between the groups. The mean resected weights of the prostate were similar (17.5 g in group 1 and 18.3 g in group 2, respectively; p>0.05). CONCLUSIONS: TURP has been steadily performed in patients with benign prostatic hyperplasia and it is expected to remain constant. LUTS was the most common indication for TURP in recent years.
RESUMO
Leukemia and brain cancer patients under age 15 years, along with controls with respiratory illnesses who were matched to cases on age, sex, and year of diagnosis (1993-1999), were selected from 14 South Korean hospitals using the South Korean Medical Insurance Data System. Diagnoses were confirmed through the South Korean National Cancer Registry. Residential addresses were obtained from medical records. A newly developed prediction program incorporating a geographic information system that was modified by the results of actual measurements was used to estimate radio-frequency radiation (RFR) exposure from 31 amplitude modulation (AM) radio transmitters with a power of 20 kW or more. A total of 1,928 leukemia patients, 956 brain cancer patients, and 3,082 controls were analyzed. Cancer risks were estimated using conditional logistic regression adjusted for residential area, socioeconomic status, and community population density. The odds ratio for all types of leukemia was 2.15 (95% confidence interval (CI): 1.00, 4.67) among children who resided within 2 km of the nearest AM radio transmitter as compared with those resided more than 20 km from it. For total RFR exposure from all transmitters, odds ratios for lymphocytic leukemia were 1.39 (95% CI: 1.04, 1.86) and 1.59 (95% CI: 1.19, 2.11) for children in the second and third quartiles, respectively, versus the lowest quartile. Brain cancer and infantile cancer were not associated with AM RFR.
Assuntos
Neoplasias Encefálicas/epidemiologia , Neoplasias Encefálicas/etiologia , Exposição Ambiental/efeitos adversos , Leucemia Induzida por Radiação/epidemiologia , Leucemia Induzida por Radiação/etiologia , Neoplasias Induzidas por Radiação/epidemiologia , Neoplasias Induzidas por Radiação/etiologia , Ondas de Rádio/efeitos adversos , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Coreia (Geográfico)/epidemiologia , Leucemia Mieloide/epidemiologia , Leucemia Mieloide/etiologia , Modelos Logísticos , Masculino , Razão de Chances , Densidade Demográfica , Leucemia-Linfoma Linfoblástico de Células Precursoras/epidemiologia , Leucemia-Linfoma Linfoblástico de Células Precursoras/etiologia , Sistema de Registros , Características de Residência , Fatores SocioeconômicosRESUMO
OBJECTIVES: In spite of the recent increased concern for Asian dust storms, there are few studies concerning how dangerous the general public recognizes these dust storms to be. This study examined the public's perceptions of the risk of the Asian dust storms and also the source of the information concerning the risk. METHODS: A telephone interview survey using a standardized questionnaire was done for the adults living in Seoul and its metropolitan area from May 15th, 2003 to May 16th, 2003. The contents of the questionnaire were the sociodemographic characteristics, the perceptions of risk to the Asian dust storms, and the coping strategy of the study participants. RESULTS: The study participants get their information on Asian dust storms mainly from TV newscasts and they have a good knowledge of them. They regard it as one of the most dangerous health risks, along with dioxin. They think that it is associated with allergic rhinitis, conjunctivitis and bronchial asthma, etc. Of the 500 study participants, 201(40.2%) persons suffered bodily discomforts during the Asian dust storm period. CONCLUSIONS: Although there are uncertainties about the health risks of Asian dust storms, the public thinks these dust storms are very dangerous to health in many ways. This negative perception will not disappear easily. To fill the gap of the public's perceptions of the risk and the objective evidence of its health effects, more studies about its health effects and the methods to reduce exposure are required.
Assuntos
Poluentes Atmosféricos/efeitos adversos , Poluição do Ar/efeitos adversos , Poeira , Conhecimentos, Atitudes e Prática em Saúde , Saúde da População Urbana , Vento , Adulto , Feminino , Humanos , Coreia (Geográfico) , Masculino , Pessoa de Meia-Idade , Percepção , Gestão de Riscos , Fatores SocioeconômicosRESUMO
OBJECTIVES: This study was conducted to investigate the prevalence of childhood obesity, the association between the undesirable lifestyles and socioeconomic factors, the association between childhood obesity and various risk factors, including socioeconomic factors, and the agreement between the body mass index (BMI) classification and the body fat percentage. METHODS: The study subjects were all the 5th grade students from all the elementary schools in Gunpo City, Kyunggi Province, South Korea (4043 children at 22 schools). The subjects were measured for their height, weight and percent body fat etc. and they were also surveyed by questionnaire from March 18th to April 25th, 2005. To determine whether the children were within normal limits or not, standardized BMIs for each age group were used. The data was analyzed by logistic regression analysis using SAS 9.0 version. RESULTS: The prevalence of childhood obesity prevalence was 25.1%. Boys had a higher prevalence of obesity (27.5%) than did the girls (22.5%). Children had tendencies of having undesirable lifestyles and getting obese if they had a lower socioeconomic status. The risk factors for childhood obesity were low paternal education (OR: 1.17, 95% CI: 0.97-1.42) and non-parental caregivers (OR: 1.34, 95% CI: 0.98-1.82). Other risk factors for childhood obesity were a high birth-weight, longer TV/computer-using time, a lower fruit-eating frequency, short sleeping hours and parental obesity. The agreement rate between the BMI classification and the body fat percentage was 93.1%. CONCLUSIONS: This study showed the children had a higher prevalence of obesity: further, not only individual lifestyles, but also socioeconomic factors could influence childhood obesity. Childhood obesity was especially more problematic for children with a low socioeconomic status.