Detalhe da pesquisa
1.
Interplay of Amino Acid Residues at Positions 28 and 31 in NS5A Defines Resistance Pathways in HCV GT2.
Antimicrob Agents Chemother
; 63(12)2019 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31527040
2.
Efficacy and safety of elbasvir/grazoprevir in participants with hepatitis C virus genotype 1, 4, or 6 infection from the Asia-Pacific region and Russia: Final results from the randomized C-CORAL study.
J Gastroenterol Hepatol
; 34(1): 12-21, 2019 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-30311701
3.
Unraveling the structural basis of grazoprevir potency against clinically relevant substitutions in hepatitis C virus NS3/4A protease from genotype 1a.
J Biol Chem
; 292(15): 6202-6212, 2017 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28228479
4.
In Vitro Antiviral Profile of Ruzasvir, a Potent and Pangenotype Inhibitor of Hepatitis C Virus NS5A.
Antimicrob Agents Chemother
; 62(11)2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30150466
5.
MK-8325: A silyl proline-containing NS5A inhibitor with pan-genotype activity for treatment of HCV.
Bioorg Med Chem Lett
; 28(10): 1954-1957, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29653894
6.
Antiviral Activity and Resistance Analysis of NS3/4A Protease Inhibitor Grazoprevir and NS5A Inhibitor Elbasvir in Hepatitis C Virus GT4 Replicons.
Antimicrob Agents Chemother
; 61(7)2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28416549
7.
The Combination of Grazoprevir, a Hepatitis C Virus (HCV) NS3/4A Protease Inhibitor, and Elbasvir, an HCV NS5A Inhibitor, Demonstrates a High Genetic Barrier to Resistance in HCV Genotype 1a Replicons.
Antimicrob Agents Chemother
; 60(5): 2954-64, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26926625
8.
Discovery of 2-(4-sulfonamidophenyl)-indole 3-carboxamides as potent and selective inhibitors with broad hepatitis C virus genotype activity targeting HCV NS4B.
Bioorg Med Chem Lett
; 26(2): 594-601, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26652483
9.
Alternative core development around the tetracyclic indole class of HCV NS5A inhibitors.
Bioorg Med Chem Lett
; 26(20): 5132-5137, 2016 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27634194
10.
Structure-activity relationships of proline modifications around the tetracyclic-indole class of NS5A inhibitors.
Bioorg Med Chem Lett
; 26(21): 5354-5360, 2016 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27680588
11.
Substituted tetracyclic indole core derivatives of HCV NS5A inhibitor MK-8742.
Bioorg Med Chem Lett
; 26(19): 4851-4856, 2016 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27568086
12.
Aryl or heteroaryl substituted aminal derivatives of HCV NS5A inhibitor MK-8742.
Bioorg Med Chem Lett
; 26(15): 3414-20, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27394665
13.
Alkyl substituted aminal derivatives of HCV NS5A inhibitor MK-8742.
Bioorg Med Chem Lett
; 26(15): 3800-5, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27282742
14.
Discovery of potent macrocyclic HCV NS5A inhibitors.
Bioorg Med Chem Lett
; 26(15): 3793-9, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27282743
15.
Discovery of fused tricyclic core containing HCV NS5A inhibitors with pan-genotype activity.
Bioorg Med Chem Lett
; 26(13): 3158-3162, 2016 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27180013
16.
Matched and mixed cap derivatives in the tetracyclic indole class of HCV NS5A inhibitors.
Bioorg Med Chem Lett
; 26(16): 4106-11, 2016 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27423481
17.
Discovery of silyl proline containing HCV NS5A inhibitors with pan-genotype activity: SAR development.
Bioorg Med Chem Lett
; 26(5): 1475-9, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26850003
18.
Susceptibilities of genotype 1a, 1b, and 3 hepatitis C virus variants to the NS5A inhibitor elbasvir.
Antimicrob Agents Chemother
; 59(11): 6922-9, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26303801
19.
Kinetic analyses reveal potent and early blockade of hepatitis C virus assembly by NS5A inhibitors.
Gastroenterology
; 147(2): 453-62.e7, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24768676
20.
Efficacy and safety of elbasvir/grazoprevir in treatment-naive Chinese adults with hepatitis C virus infection: A randomized trial.
JGH Open
; 4(6): 1065-1073, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-33319038