Detalhe da pesquisa
1.
Esmethadone-HCl (REL-1017): a promising rapid antidepressant.
Eur Arch Psychiatry Clin Neurosci
; 273(7): 1463-1476, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-36890259
2.
Esmethadone (REL-1017) and Other Uncompetitive NMDAR Channel Blockers May Improve Mood Disorders via Modulation of Synaptic Kinase-Mediated Signaling.
Int J Mol Sci
; 23(20)2022 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36293063
3.
Understanding Opioid Actions, Pain and Analgesia: A Tribute to Dr. Gavril Pasternak.
Cell Mol Neurobiol
; 41(5): 827-834, 2021 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-33978862
4.
Letter to the Editor regarding 'Unique pharmacodynamic properties and low abuse liability of the µ-opioid receptor ligand (S)-methadone'.
Mol Psychiatry
; 2024 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38806691
5.
Stabilization of the µ-opioid receptor by truncated single transmembrane splice variants through a chaperone-like action.
J Biol Chem
; 288(29): 21211-21227, 2013 Jul 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-23760268
6.
Cav1.3 L-type Ca2+ channel-activated CaMKII/ERK2 pathway in the ventral tegmental area is required for cocaine conditioned place preference.
Neuropharmacology
; 224: 109368, 2023 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36481277
7.
Drug-Drug Interaction Studies of Esmethadone (REL-1017) Involving CYP3A4- and CYP2D6-Mediated Metabolism.
Drugs R D
; 2023 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38010591
8.
The novel uncompetitive NMDA receptor antagonist esmethadone (REL-1017) has no meaningful abuse potential in recreational drug users.
Transl Psychiatry
; 13(1): 192, 2023 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37286536
9.
Cav1.2 L-type Ca²âº channels mediate cocaine-induced GluA1 trafficking in the nucleus accumbens, a long-term adaptation dependent on ventral tegmental area Ca(v)1.3 channels.
J Neurosci
; 31(38): 13562-75, 2011 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21940447
10.
The N-Methyl-D-Aspartate Receptor Blocker REL-1017 (Esmethadone) Reduces Calcium Influx Induced by Glutamate, Quinolinic Acid, and Gentamicin.
Pharmaceuticals (Basel)
; 15(7)2022 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35890179
11.
Pharmacological Comparative Characterization of REL-1017 (Esmethadone-HCl) and Other NMDAR Channel Blockers in Human Heterodimeric N-Methyl-D-Aspartate Receptors.
Pharmaceuticals (Basel)
; 15(8)2022 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36015145
12.
REL-1017 (Esmethadone) as Adjunctive Treatment in Patients With Major Depressive Disorder: A Phase 2a Randomized Double-Blind Trial.
Am J Psychiatry
; 179(2): 122-131, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34933568
13.
Estradiol-induced antinociceptive responses on formalin-induced nociception are independent of COX and HPA activation.
Synapse
; 65(7): 643-51, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21132813
14.
Improving the pharmacologic management of pain in older adults: identifying the research gaps and methods to address them.
Pain Med
; 12(9): 1336-57, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21834914
15.
The effect of obesity on pain severity and pain interference.
Pain Manag
; 11(5): 571-581, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-34102863
16.
REL-1017 (Esmethadone) Increases Circulating BDNF Levels in Healthy Subjects of a Phase 1 Clinical Study.
Front Pharmacol
; 12: 671859, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33995104
17.
Activation of the neuronal extracellular signal-regulated kinase 2 in the spinal cord dorsal horn is required for complete Freund's adjuvant-induced pain hypersensitivity.
J Neurosci
; 28(52): 14087-96, 2008 Dec 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-19109491
18.
Deletion of the glutamate receptor 5 subunit of kainate receptors affects the development of morphine tolerance.
J Pharmacol Exp Ther
; 328(2): 579-87, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18957577
19.
Does transdermal fentanyl work in patients with low BMI? Patient-reported outcomes of pain and percent pain relief in cancer patients on transdermal fentanyl.
Cancer Med
; 8(18): 7516-7522, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31568684
20.
Acute and chronic heroin dependence in mice: contribution of opioid and excitatory amino acid receptors.
Eur J Pharmacol
; 586(1-3): 179-88, 2008 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-18343363