Detalhe da pesquisa
1.
Identification and characterization of the first fragment hits for SETDB1 Tudor domain.
Bioorg Med Chem
; 27(17): 3866-3878, 2019 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31327677
2.
Conformational dynamics of the TTD-PHD histone reader module of the UHRF1 epigenetic regulator reveals multiple histone-binding states, allosteric regulation, and druggability.
J Biol Chem
; 292(51): 20947-20959, 2017 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29074623
3.
Studies on deacetoxycephalosporin C synthase support a consensus mechanism for 2-oxoglutarate dependent oxygenases.
Biochemistry
; 53(15): 2483-93, 2014 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-24684493
4.
Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway.
Acta Crystallogr D Biol Crystallogr
; 69(Pt 8): 1567-79, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23897479
5.
A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II.
Nat Commun
; 13(1): 5453, 2022 09 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36114190
6.
Structural and biochemical analyses reveal how ornithine acetyl transferase binds acidic and basic amino acid substrates.
Org Biomol Chem
; 9(18): 6219-25, 2011 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21796301
7.
Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway.
Proteins
; 78(6): 1398-407, 2010 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20014241
8.
Anatomy of a simple acyl intermediate in enzyme catalysis: combined biophysical and modeling studies on ornithine acetyl transferase.
J Am Chem Soc
; 131(2): 749-57, 2009 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-19105697
9.
Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP).
J Med Chem
; 60(11): 4611-4625, 2017 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28492317
10.
Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors.
ACS Med Chem Lett
; 6(7): 798-803, 2015 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26191369
11.
Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.
J Med Chem
; 58(16): 6574-88, 2015 Aug 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-26218264
12.
Crystal structures of an oligopeptide-binding protein from the biosynthetic pathway of the beta-lactamase inhibitor clavulanic acid.
J Mol Biol
; 396(2): 332-44, 2010 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-19941870