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1.
Nature ; 601(7894): 588-594, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-34937049

RESUMO

Present-day people from England and Wales have more ancestry derived from early European farmers (EEF) than did people of the Early Bronze Age1. To understand this, here we generated genome-wide data from 793 individuals, increasing data from the Middle to the Late Bronze Age and Iron Age in Britain by 12-fold, and western and central Europe by 3.5-fold. Between 1000 and 875 BC, EEF ancestry increased in southern Britain (England and Wales) but not northern Britain (Scotland) due to incorporation of migrants who arrived at this time and over previous centuries, and who were genetically most similar to ancient individuals from France. These migrants contributed about half the ancestry of people of England and Wales from the Iron Age, thereby creating a plausible vector for the spread of early Celtic languages into Britain. These patterns are part of a broader trend of EEF ancestry becoming more similar across central and western Europe in the Middle to the Late Bronze Age, coincident with archaeological evidence of intensified cultural exchange2-6. There was comparatively less gene flow from continental Europe during the Iron Age, and the independent genetic trajectory in Britain is also reflected in the rise of the allele conferring lactase persistence to approximately 50% by this time compared to approximately 7% in central Europe where it rose rapidly in frequency only a millennium later. This suggests that dairy products were used in qualitatively different ways in Britain and in central Europe over this period.


Assuntos
Arqueologia , Fazendeiros , Europa (Continente) , França , Genoma Humano/genética , Migração Humana/história , Humanos , Lactente , Reino Unido
2.
Nature ; 600(7890): 695-700, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-34880504

RESUMO

Surveys are a crucial tool for understanding public opinion and behaviour, and their accuracy depends on maintaining statistical representativeness of their target populations by minimizing biases from all sources. Increasing data size shrinks confidence intervals but magnifies the effect of survey bias: an instance of the Big Data Paradox1. Here we demonstrate this paradox in estimates of first-dose COVID-19 vaccine uptake in US adults from 9 January to 19 May 2021 from two large surveys: Delphi-Facebook2,3 (about 250,000 responses per week) and Census Household Pulse4 (about 75,000 every two weeks). In May 2021, Delphi-Facebook overestimated uptake by 17 percentage points (14-20 percentage points with 5% benchmark imprecision) and Census Household Pulse by 14 (11-17 percentage points with 5% benchmark imprecision), compared to a retroactively updated benchmark the Centers for Disease Control and Prevention published on 26 May 2021. Moreover, their large sample sizes led to miniscule margins of error on the incorrect estimates. By contrast, an Axios-Ipsos online panel5 with about 1,000 responses per week following survey research best practices6 provided reliable estimates and uncertainty quantification. We decompose observed error using a recent analytic framework1 to explain the inaccuracy in the three surveys. We then analyse the implications for vaccine hesitancy and willingness. We show how a survey of 250,000 respondents can produce an estimate of the population mean that is no more accurate than an estimate from a simple random sample of size 10. Our central message is that data quality matters more than data quantity, and that compensating the former with the latter is a mathematically provable losing proposition.


Assuntos
Vacinas contra COVID-19/administração & dosagem , Pesquisas sobre Atenção à Saúde , Vacinação/estatística & dados numéricos , Benchmarking , Viés , Big Data , COVID-19/epidemiologia , COVID-19/prevenção & controle , Centers for Disease Control and Prevention, U.S. , Conjuntos de Dados como Assunto/normas , Feminino , Pesquisas sobre Atenção à Saúde/normas , Humanos , Masculino , Projetos de Pesquisa , Tamanho da Amostra , Mídias Sociais , Estados Unidos/epidemiologia , Hesitação Vacinal/estatística & dados numéricos
3.
PLoS One ; 12(10): e0186054, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-29073226

RESUMO

Academic dishonesty has been and continues to be a major problem in America's schools and universities. Such dishonesty is especially important in high schools, where grades earned directly impact the academic careers of students for many years to come. The rising pressure to get the best grades in school, get into the best college, and land the best paying job is a cycle that has made academic dishonesty increase exponentially. Thus, finding the widespread roots of cheating is more important now than ever. In this study, we focus on how societal norms and interactions with peers influence lying about scores in order to obtain a benefit in a high school population. We show that (1) the societal norms that go hand in hand with test-taking in school, as administered by a teacher, significantly dampen small-scale dishonesty, perhaps suggesting that context-dependent rewards offset cheating; (2) providing reminders of societal norms via pre-reported average scores leads to more truthful self-reporting of honesty; (3) the matrix search task was shown to not depend on class difficulty, confirming its effectiveness as an appropriate method for this study; (4) males seem to cheat more than females; and (5) teenagers are more dishonest earlier in the day. We suggest that students understand that cheating is wrong, an idea backed up by the literature, and that an environment which clearly does not condone dishonesty helps dampen widespread cheating in certain instances. This dampening effect seems to be dependent on the reward that students thought they would get for exaggerating their performance.


Assuntos
Enganação , Recompensa , Adulto , Feminino , Humanos , Masculino , Estados Unidos , Universidades , Adulto Jovem
4.
Sci Rep ; 6: 24224, 2016 Apr 13.
Artigo em Inglês | MEDLINE | ID: mdl-27071543

RESUMO

Recent research using 3D printing to create active structures has added an exciting new dimension to 3D printing technology. After being printed, these active, often composite, materials can change their shape over time; this has been termed as 4D printing. In this paper, we demonstrate the design and manufacture of active composites that can take multiple shapes, depending on the environmental temperature. This is achieved by 3D printing layered composite structures with multiple families of shape memory polymer (SMP) fibers - digital SMPs - with different glass transition temperatures (Tg) to control the transformation of the structure. After a simple single-step thermomechanical programming process, the fiber families can be sequentially activated to bend when the temperature is increased. By tuning the volume fraction of the fibers, bending deformation can be controlled. We develop a theoretical model to predict the deformation behavior for better understanding the phenomena and aiding the design. We also design and print several flat 2D structures that can be programmed to fold and open themselves when subjected to heat. With the advantages of an easy fabrication process and the controllable multi-shape memory effect, the printed SMP composites have a great potential in 4D printing applications.

5.
Sci Rep ; 6: 24761, 2016 04 25.
Artigo em Inglês | MEDLINE | ID: mdl-27109063

RESUMO

The creation of reversibly-actuating components that alter their shapes in a controllable manner in response to environmental stimuli is a grand challenge in active materials, structures, and robotics. Here we demonstrate a new reversible shape-changing component design concept enabled by 3D printing two stimuli responsive polymers-shape memory polymers and hydrogels-in prescribed 3D architectures. This approach uses the swelling of a hydrogel as the driving force for the shape change, and the temperature-dependent modulus of a shape memory polymer to regulate the time of such shape change. Controlling the temperature and aqueous environment allows switching between two stable configurations - the structures are relatively stiff and can carry load in each - without any mechanical loading and unloading. Specific shape changing scenarios, e.g., based on bending, or twisting in prescribed directions, are enabled via the controlled interplay between the active materials and the 3D printed architectures. The physical phenomena are complex and nonintuitive, and so to help understand the interplay of geometric, material, and environmental stimuli parameters we develop 3D nonlinear finite element models. Finally, we create several 2D and 3D shape changing components that demonstrate the role of key parameters and illustrate the broad application potential of the proposed approach.

6.
Sci Rep ; 5: 13616, 2015 Sep 08.
Artigo em Inglês | MEDLINE | ID: mdl-26346202

RESUMO

Folding is ubiquitous in nature with examples ranging from the formation of cellular components to winged insects. It finds technological applications including packaging of solar cells and space structures, deployable biomedical devices, and self-assembling robots and airbags. Here we demonstrate sequential self-folding structures realized by thermal activation of spatially-variable patterns that are 3D printed with digital shape memory polymers, which are digital materials with different shape memory behaviors. The time-dependent behavior of each polymer allows the temporal sequencing of activation when the structure is subjected to a uniform temperature. This is demonstrated via a series of 3D printed structures that respond rapidly to a thermal stimulus, and self-fold to specified shapes in controlled shape changing sequences. Measurements of the spatial and temporal nature of self-folding structures are in good agreement with the companion finite element simulations. A simplified reduced-order model is also developed to rapidly and accurately describe the self-folding physics. An important aspect of self-folding is the management of self-collisions, where different portions of the folding structure contact and then block further folding. A metric is developed to predict collisions and is used together with the reduced-order model to design self-folding structures that lock themselves into stable desired configurations.

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