1.
Bioorg Med Chem Lett
; 23(14): 4080-4, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23768908
RESUMO
Stable, nanosized polyelectrolyte complexes between rationally designed thermally sensitive block copolymers and plasmid DNA (polyplexes) were formed and their in vitro transfection efficiency was tested. The polyplexes were further stabilized through encapsulation into a biodegradable polymer shell. Although reduced as compared to that of the corresponding polyplexes, the encapsulated systems still show acceptable transfection efficiency. That opens the possibility to tune the balance between the safe transport and efficient delivery of DNA into the cells.