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1.
J Clin Psychol Med Settings ; 29(4): 785-797, 2022 12.
Artigo em Inglês | MEDLINE | ID: mdl-35048253

RESUMO

This study investigated the effects of massage therapy (MT), high-intensity interval training (HIIT), and neuromuscular electrical stimulation (NMES) as three physical therapies on pain perception and negative emotional state (NES) in males with chronic joint pain (CJP). This double-blind randomized experimental study was done with three pretest, posttest, and follow-up stages within three experimental groups and the control group. Participants recruited by a random sampling method in each group that they were 160 patients with CJP. A demographic questionnaire, the Short-Form-McGill Pain Questionnaire (SF-MPQ), and Depression, Anxiety and Stress Scale- 21 (DASS-SF-21) were used in this study. Findings showed significant differences in the effectiveness of MT, HIIT, and NMES on pain symptoms and NES in experimental and control groups during post-test and follow-up stages. The MT, HIIT, and NMES were effective in decreasing the sensory experience of pain, the affective experience of pain, the present pain intensity (PPI), and depression, anxiety, and stress among outpatients with CJP in the experimental groups during post-test and follow-up stages. NMES, HIIT, and MT may be considered by health professionals as effective interventions to reduce pain perception and NES in patients with CJP.


Assuntos
Dor Crônica , Percepção da Dor , Masculino , Humanos , Medição da Dor , Dor , Ansiedade/terapia , Artralgia , Dor Crônica/terapia
2.
Int Wound J ; 16(4): 960-967, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-30950218

RESUMO

Negative pressure wound therapy (NPWT) represents one of the many solutions for complex wounds of the upper extremity. The goal of this study was to investigate the most common indications for definitive treatment of wound defects in the upper extremity with NPWT and to report revision surgery outcomes after its use. A systematic review of the literature was performed. The following keywords and their combinations were used: "upper extremity," "arm," "forearm," "wrist," "hand," "finger" AND "negative-pressure wound therapy," "VAC therapy," "vacuum assisted closure." A total of 45 articles were included, regrouping 404 cases of NPWT in the upper extremity. The forearm was involved in 53% of cases, followed by hand (36%), fingers (10%), and arm (1%). Seventeen different indications were cited, the most common of which were radial forearm flap reconstruction (23%), burn wounds (18%), and compartment syndromes (17%). Of the cases, 90% did not require any subsequent surgical procedure, as opposed to 6% considered partial failures requiring minor revisions and 4% total failures requiring major revisions. Closure of radial forearm flap donor site required the most revision procedures when treated with NPWT. NPWT can be used for several indications pertaining to the reconstruction of the upper extremity. Positive outcomes as a definitive treatment are demonstrated in this systematic review, which reaffirms NPWT as a potent tool for reconstructive endeavours.


Assuntos
Traumatismos do Braço/cirurgia , Tratamento de Ferimentos com Pressão Negativa/métodos , Procedimentos de Cirurgia Plástica , Transplante de Pele/métodos , Retalhos Cirúrgicos/transplante , Cicatrização/fisiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
3.
J Reconstr Microsurg ; 34(9): 692-700, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-29689575

RESUMO

BACKGROUND: After thumb amputations, restoration of function and aesthetic can be accomplished with microvascular free toe flaps. However, many patients in clinical practice do not choose this reconstruction despite positive reported outcomes. This study aims to determine patients' perceptions with respect to free toe flaps to improve areas of informed consent. METHODS: A retrospective survey was administered to patients with thumb amputations. Participants were required to complete a questionnaire about patient demographics, the Brief Michigan Hand Questionnaire (bMHQ), the standard gamble/time trade-off questionnaires for utility scores, and a questionnaire investigating potential reasons for electing not to undergo a free toe transfer. RESULTS: Thirty patients were enrolled in the study wherein 53% underwent a replantation procedure, 27% a revision amputation, and 20% a delayed reconstruction. Mean normalized score on the bMHQ was recorded as 63.54. Utility questionnaires yielded mean measures of 0.8967 and 0.86 on the standard gamble and time trade-off, respectively. From 14 elements, a majority (87%) stated flap failure as a major source of concern, followed by lack of understanding of risks and benefits (80%) and prolonged hospital stay (53%). Cultural/religious beliefs, aesthetic appearance of the foot, and concerns about footwear were not reported as important reasons in 90, 80, and 79% of patients, respectively. CONCLUSION: A better understanding of patients' attitudes and beliefs with respect to free toe flaps will allow surgeons to better address their concerns during informed consent. This study emphasizes the importance to discuss about failure rates, risks, and benefits of the operation and prolonged hospital stay.


Assuntos
Amputação Traumática , Estética/psicologia , Consentimento Livre e Esclarecido/estatística & dados numéricos , Satisfação do Paciente/estatística & dados numéricos , Recuperação de Função Fisiológica/fisiologia , Reimplante/métodos , Polegar , Dedos do Pé/transplante , Amputação Traumática/psicologia , Amputação Traumática/cirurgia , Avaliação da Deficiência , Retalhos de Tecido Biológico , Humanos , Consentimento Livre e Esclarecido/psicologia , Medidas de Resultados Relatados pelo Paciente , Percepção , Guias de Prática Clínica como Assunto , Reimplante/psicologia , Estudos Retrospectivos , Inquéritos e Questionários , Dedos do Pé/irrigação sanguínea , Resultado do Tratamento
4.
J Craniofac Surg ; 26(1): 113-7, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25534061

RESUMO

BACKGROUND: Cranioplasty can be performed either with gold-standard, autologous bone grafts and osteotomies or alloplastic materials in skeletally mature patients. Recently, custom computer-generated implants (CCGIs) have gained popularity with surgeons because of potential advantages, which include preoperatively planned contour, obviated donor-site morbidity, and operative time savings. A remaining concern is the cost of CCGI production. The purpose of the present study was to objectively compare the operative time and relative cost of cranioplasties performed with autologous versus CCGI techniques at our center. METHODS: A review of all autologous and CCGI cranioplasties performed at our institution over the last 7 years was performed. The following operative variables and associated costs were tabulated: length of operating room, length of ward/intensive care unit (ICU) stay, hardware/implants utilized, and need for transfusion. RESULTS: Total average cost did not differ statistically between the autologous group (n = 15; $25,797.43) and the CCGI cohort (n = 12; $28,560.58). Operative time (P = 0.004), need for ICU admission (P < 0.001), and number of complications (P = 0.008) were all statistically significantly less in the CCGI group. The length of hospital stay and number of cases needing transfusion were fewer in the CCGI group but did not reach statistical significance. CONCLUSION: The results of the present study demonstrated no significant increase in overall treatment cost associated with the use of the CCGI cranioplasty technique. In addition, the latter was associated with a statistically significant decrease in operative time and need for ICU admission when compared with those patients who underwent autologous bone cranioplasty. LEVEL OF EVIDENCE: IV, therapeutic.


Assuntos
Autoenxertos/economia , Substitutos Ósseos/economia , Transplante Ósseo/economia , Desenho Assistido por Computador , Craniotomia/educação , Procedimentos de Cirurgia Plástica/economia , Adolescente , Adulto , Benzofenonas , Materiais Biocompatíveis/economia , Transfusão de Sangue/economia , Criança , Pré-Escolar , Estudos de Coortes , Custos e Análise de Custo , Cuidados Críticos/economia , Feminino , Seguimentos , Custos de Cuidados de Saúde , Unidades Hospitalares/economia , Humanos , Cetonas/economia , Tempo de Internação/economia , Masculino , Pessoa de Meia-Idade , Duração da Cirurgia , Polietilenoglicóis/economia , Polímeros , Próteses e Implantes/economia , Cirurgia Assistida por Computador/economia , Adulto Jovem
5.
Ann Plast Surg ; 73(2): 210-4, 2014 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-23528634

RESUMO

BACKGROUND: Debilitating lower extremity lymphedema can be either congenital or acquired. Utility scores are an objective measure used in medicine to quantify degrees of impact on an individual's life. Using standardized utility outcome measures, we aimed to quantify the health state of living with severe unilateral lower extremity lymphedema. METHODS: A utility outcomes assessment using visual analog scale, time trade-off, and standard gamble was used for lower extremity lymphedema, monocular blindness, and binocular blindness from a sample of the general population and medical students. Average utility scores were compared using a paired t test. Linear regression was performed using age, race, and education as independent predictors. RESULTS: A total of 144 prospective participants were included. All measures [visual analog scale, time trade-off, and standard gamble; expressed as mean (SD)] for unilateral lower extremity lymphedema (0.50 ± 0.18, 0.76 ± 0.22, and 0.76 ± 0.21, respectively) were significantly different (P < 0.001) from the corresponding scores for monocular blindness (0.64 ± 0.18, 0.84 ± 0.16, and 0.83 ± 0.17, respectively) and binocular blindness (0.35 ± 0.17, 0.61 ± 0.28, and 0.62 ± 0.26, respectively). CONCLUSIONS: We found that a sample of the general population and medical students, if faced with severe lymphedema, is willing to theoretically trade 8.64 life-years and undergo a procedure with a 24% risk of mortality to restore limb appearance and function to normal. These findings provide a frame of reference regarding the meaning of a diagnosis of severe lower extremity lymphedema to a patient and will allow objective comparison with other health states.


Assuntos
Atitude Frente a Saúde , Efeitos Psicossociais da Doença , Linfedema/psicologia , Qualidade de Vida , Índice de Gravidade de Doença , Adulto , Cegueira/psicologia , Feminino , Pesquisas sobre Atenção à Saúde , Humanos , Modelos Lineares , Linfedema/terapia , Masculino , Anos de Vida Ajustados por Qualidade de Vida , Escala Visual Analógica
6.
Ann Plast Surg ; 73 Suppl 2: S149-52, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-25046669

RESUMO

BACKGROUND: The number of patients requesting surgical procedures performed for brachioplasty and massive weight loss is increasing. The authors set out to quantify the health state utility outcome assessment of living with arm deformity requiring brachioplasty. METHODS: Utility assessments using the visual analog scale (VAS), time trade-off (TTO), and standard gamble (SG) were used to obtain utilities scores for arm deformity, monocular blindness, and binocular blindness from a sample of the general population and medical students. Linear regression and Student t test were used for statistical analysis. A P value less than 0.05 was deemed statistically significant. RESULTS: All the measures for arm deformity of the 107 volunteers (VAS, 0.80 ± 0.14; TTO, 0.91 ± 0.12; SG, 0.94 ± 0.10) were significantly different (P < 0.001) from the corresponding measures for monocular blindness and binocular blindness. When compared to the sample of the general population, having a medical education demonstrated a statistical significance of being less likely to trade years of life and less likely to gamble risk of death for a procedure such as a brachioplasty. Race and sex were not statistically significant independent predictors of risk acceptance. CONCLUSIONS: We have objectified the health state of living with upper arm deformity requiring brachioplasty. Utility outcome scores (VAS, 0.80 ± 0.14; TTO, 0.91 ± 0.12; SG, 0.94 ± 0.10) were comparable to living with health states such as aging neck needing rejuvenation, excess skin in the thighs necessitating thigh lift, and massive weight loss requiring panniculectomy based on previously reported studies.


Assuntos
Braço/cirurgia , Atitude Frente a Saúde , Técnicas Cosméticas/psicologia , Nível de Saúde , Anos de Vida Ajustados por Qualidade de Vida , Adulto , Cegueira/psicologia , Efeitos Psicossociais da Doença , Feminino , Pesquisas sobre Atenção à Saúde , Humanos , Modelos Lineares , Masculino , Estudos Prospectivos , Qualidade de Vida , Inquéritos e Questionários , Escala Visual Analógica
7.
J Reconstr Microsurg ; 30(5): 313-8, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-24535675

RESUMO

BACKGROUND: The gold standard for the treatment of breast cancer includes mastectomy surgery. Our goal was to quantify the health state utility assessment of living with unilateral mastectomy. METHODS: The visual analogue scale (VAS), time trade-off (TTO), and standard gamble (SG) were used to obtain utilities for unilateral mastectomy, monocular blindness and binocular blindness from a prospective sample of the general population and medical students. RESULTS: All measures (VAS, TTO, SG) for unilateral mastectomy (0.75 SD 0.17, 0.87 SD 0.14, and 0.86 SD 0.18, respectively) of the 140 volunteers were significantly different from the corresponding scores for monocular (0.61 SD 0.18, 0.84 SD 0.17, and 0.84 SD 0.18, respectively) and binocular blindness (0.38 SD 0.17, 0.67 SD 0.24, and 0.69 SD 0.23, respectively). Age, gender, race, education, and income were not statistically significant independent predictors of utility scores. CONCLUSION: In a sample of the general population and medical students, utility assessments for living with unilateral mastectomy were comparable with those of living with bilateral mastectomy and severe breast hypertrophy. Our sample population, if faced living with unilateral mastectomy was willing to gamble a theoretical 14% chance of death and willing to trade 4.2 years of existing life-years.


Assuntos
Imagem Corporal/psicologia , Neoplasias da Mama/psicologia , Mastectomia/psicologia , Medição da Dor/psicologia , Preferência do Paciente/psicologia , Adulto , Neoplasias da Mama/cirurgia , Feminino , Indicadores Básicos de Saúde , Humanos , Masculino , Avaliação de Resultados da Assistência ao Paciente , Satisfação do Paciente , Estudos Prospectivos , Qualidade de Vida , Inquéritos e Questionários
8.
Surg Radiol Anat ; 36(10): 989-92, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-24748403

RESUMO

PURPOSE: Numerous studies have attempted to clarify the exact anatomy and variations of the optic canal with non-conclusive results due to its close proximity to many vulnerable structures. We sought to determine the dynamics of growth and development of these structures on fetal skulls, which will help us to better understand of gender and age-dependent variations, as well as fatal malformations. METHODS: Fifteen previously macerated fetal frontal and sphenoid bones were analyzed and the diameters of optic canal, and distance of orbit from frontomaxillary suture to frontozygomatic suture were measured using 3D reconstruction images obtained by micro-CT. RESULTS: Average diameter of the optic canal in 300 mm fetus was measured to be 1,546 ± 36 µm, in 400 mm fetus 2,470 ± 123 µm and in 500 mm fetus 3,757 ± 203 µm. This trend indicates a linear enlargement of optic canal during the fetal period. During the same time period, diameter of the orbit enlarges from 12,319 ± 559 µm in 300 mm fetus to 19,788 ± 736 µm in 500 mm fetus. Growth curve is significantly lower in comparison with the same curve in optic canal data. We also calculated the ratio of orbit diameter and optic canal diameter between those groups which decreased from a value of 7.9 ± 0.4 for 300 mm fetus to 5.3 ± 0.2 for 500 mm fetus. CONCLUSION: Dynamics of optic canal and orbital cavity development is different in early and late fetal period. Diameters of those structures are in better correlation with the fetal length.


Assuntos
Órbita/anatomia & histologia , Microtomografia por Raio-X/métodos , Pesos e Medidas Corporais/métodos , Suturas Cranianas/anatomia & histologia , Feminino , Feto/embriologia , Humanos , Imageamento Tridimensional/métodos , Masculino , Nervo Óptico/anatomia & histologia , Nervo Óptico/embriologia , Órbita/embriologia , Osso Esfenoide/anatomia & histologia , Osso Esfenoide/embriologia
9.
Indian J Plast Surg ; 47(2): 263-6, 2014 May.
Artigo em Inglês | MEDLINE | ID: mdl-25190927

RESUMO

Abdominoplasty is among the most commonly performed aesthetic procedures in plastic surgery. Despite high complication rate, abdominal contouring procedures are expected to rise in popularity with the advent of bariatric surgery. Patients with a history of gastric bypass surgery have an elevated incidence of small bowel obstruction from internal herniation, which is associated with non-specific upper abdominal pain, nausea, and a decrease in appetite. Internal hernias, when subjected to elevated intra-abdominal pressures, have a high-risk of developing ischemic bowel. We present a case report of patient with previous laparoscopic Roux-en-y gastric bypass who developed acute ischemic bowel leading to abdominal compartment syndrome following abdominoplasty. To the best of our knowledge, this is the first reported case in the literature. We herein emphasise on the subtle symptoms and signs that warrant further investigations in prospective patients for an abdominal contouring procedure with a prior history of gastric bypass surgery.

10.
Am J Physiol Regul Integr Comp Physiol ; 305(5): R552-7, 2013 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-23883675

RESUMO

Lifestyle intervention programs currently emphasize weight loss secondary to obesity as the primary determinant of phenotypic changes. We examined whether the effects of a short-term lifestyle intervention program differ in normal-weight versus overweight/obese children. Nineteen overweight/obese (O; BMI = 33.6 ± 1.9 kg/m(2)) and 14 normal-weight (N; BMI = 19.9 ± 1.5 kg/m(2)) children participated in a 2-wk program consisting of an ad libitum high-fiber, low-fat diet and daily exercise (2-2.5 h). Fasting serum samples were taken pre- and postintervention for determination of lipids, glucose homeostasis, inflammatory cytokines, and adipokines. Only the O group lost weight (3.9%) but remained overweight/obese (32.3 ± 1.9 kg/m(2)). Both groups exhibited significant intervention-induced decreases (P < 0.05) in serum insulin (N: 52.5% vs. O: 28.1%; between groups, P = 0.38), homeostatic model assessment for insulin resistance (N: 53.1% vs. O: 28.4%, P = 0.43), leptin (N: 69.3% vs. O: 44.1%, P = 0.10), amylin (N: 28.7% vs. O: 26.1%, P = 0.80), resistin (N: 40.0% vs. O: 35.1%, P = 0.99), plasminogen activator-inhibitor-1 (N: 30.8% vs. O: 25.6%, P = 0.59), IL-6 (N: 58.8% vs. O: 48.5%, P = 0.78), IL-8 (N: 46.0% vs. O: 42.2%, P = 0.49), and TNFα (N: 45.8% vs. O: 40.8%, P = 0.99). No associations between indices of weight change and phenotypic changes were noted. A short-term, intensive lifestyle modification program is effective in ameliorating metabolic risk factors in N and O children. These results suggest that obesity per se was not the primary driver of the phenotypes noted and that dietary intake and physical inactivity induce the phenotypic abnormalities. These data may have implications for the weight loss-independent management of cardiometabolic risk in pediatric populations.


Assuntos
Peso Corporal , Dietoterapia/métodos , Terapia por Exercício/métodos , Insulina/sangue , Obesidade/fisiopatologia , Obesidade/terapia , Comportamento de Redução do Risco , Adolescente , Criança , Terapia Combinada/métodos , Feminino , Humanos , Masculino , Valores de Referência , Resultado do Tratamento
11.
Ann Plast Surg ; 71(3): 304-7, 2013 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-23788144

RESUMO

BACKGROUND: The presence of excess skin after massive weight loss, particularly in the thighs, not only contributes to a negative body image but can also lead to functional deficits in mobility. In the present study, we quantified the health state utility of living with excess skin in the thighs in an attempt to objectively establish the burden on the quality of life in patients living with excess thigh skin laxity. METHOD: Using visual analog scale (VAS), time trade-off (TTO), and standard gamble (SG), we compared the utility outcome scores for thigh skin excess with monocular and binocular blindness from a prospective sample of medical students and the general population. Utility scores were compared using paired t test. Linear regression was performed using age, race, and education as independent predictors of each of the utility scores. RESULTS: One hundred thirty-four prospective participants were enrolled during a 6-month period, and 112 participants met our inclusion criteria. The utility outcome scores for thigh lift (VAS, TTO, and SG, 0.77 ± 0.15, 0.90 ± 0.11, and 0.89 ± 0.14, respectively) were statistically different from binocular blindness (VAS, TTO, and SG, 0.37 ± 0.18, 0.70 ± 0.23, and 0.70 ± 0.26; P < 0.001), but other than VAS (0.67 ± 0.15, P < 0.001), similar to monocular blindness (TTO and SG, 0.89 ± 0.13 and 0.81 ± 0.14, respectively; P > 0.05). SG (0.89 ± 0.14 vs 0.97 ± 0.02, P = 0.003) and TTO (0.89 ± 0.11 vs 0.95 ± 0.03, P = 0.038) were different between general population and medical students, respectively, corresponding to 3.96 versus 1.80 potential years willing to be traded (P < 0.05). Additionally, SG was higher in whites versus nonwhites who were willing to take a potential 8% chance of mortality compared to 15%, respectively (P = 0.001), to achieve "perfect" health. CONCLUSIONS: We have objectified the utility of living with thigh deformity after massive weight loss. Our sample population if faced with the condition was willing to sacrifice a potential 3.6 years of life and potentially undergo a procedure with 11% chance of mortality to address excess thigh laxity.


Assuntos
Atitude Frente a Saúde , Técnicas Cosméticas/psicologia , Procedimentos Cirúrgicos Dermatológicos/psicologia , Qualidade de Vida , Anos de Vida Ajustados por Qualidade de Vida , Coxa da Perna/cirurgia , Redução de Peso , Adulto , Cegueira/psicologia , Efeitos Psicossociais da Doença , Feminino , Pesquisas sobre Atenção à Saúde , Necessidades e Demandas de Serviços de Saúde , Humanos , Modelos Lineares , Masculino , Estudos Prospectivos , Pele/patologia , Coxa da Perna/patologia , Escala Visual Analógica
12.
J Craniofac Surg ; 24(1): 120-5, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23348267

RESUMO

BACKGROUND: Cardiopulmonary bypass (CBP) and circulatory arrest as an assist in the surgical excision of a severe facial vascular malformation were first described by Mulliken et al in 1979. Later on, its use had expanded for resection of intracranial vascular malformations. However, to date, there have not been any published series of these procedures being used in the resection of craniofacial vascular malformations. We sought to review the first 10 surgical procedures performed at McGill University Health Centre for large vascular malformations resection using hypothermic CBP with or without circulatory arrest. METHODS: All consecutive patients at the McGill University Health Centre who had a craniofacial vascular malformation resected with the aid of CBP were reviewed. A comparison of the classic midline sternotomy with cardiac arrest to percutaneous femoral bypass with hypothermic "low flow" was performed. Charts were reviewed for the operative intervention including bypass parameters and short- and long-term complications of the procedure. RESULTS: Cardiopulmonary bypass was used in 9 patients for 10 surgical procedures for the resection of a variety of craniofacial vascular malformations from 1987 to 2001. All lesions had sclerotherapy and embolization of the feeding vessels 72 to 96 hours preoperatively. The average age of our patients was 21 ± 13.4 years (2-37 years). Procedures were conducted via either an open bypass or a closed femoral approach. There were no mortalities. There were 2 major cardiac intraoperative complications and 1 major postoperative complication, which were managed with no sequelae. The average length of postoperative hospital stay was 10 days. All patients went on to full recovery. The blood transfusions varied from 10 U to 0 U for our last patient. CONCLUSIONS: The assistance and adjunct of CBP are a useful procedure in the resection of very large vascular malformations, in selected cases. There were no major long-term complications in this series. With the evolution of our approach, the use of complete circulatory arrest was not required in the majority of cases, and an adequate resection was usually possible with the low-flow state alone as we developed this technique with more experience through the process.


Assuntos
Anormalidades Craniofaciais/cirurgia , Malformações Vasculares/cirurgia , Adolescente , Adulto , Angiografia , Transfusão de Sangue/estatística & dados numéricos , Ponte Cardiopulmonar , Criança , Pré-Escolar , Embolização Terapêutica , Feminino , Parada Cardíaca Induzida , Humanos , Hipotermia Induzida , Lactente , Masculino , Duração da Cirurgia , Estudos Retrospectivos , Escleroterapia , Esternotomia , Resultado do Tratamento
14.
Am J Physiol Endocrinol Metab ; 303(4): E542-50, 2012 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-22713506

RESUMO

The present study was designed to examine the effects of short-term diet and exercise on markers of metabolic health, serum-stimulated production of inflammatory biomarkers from cultured monocytes and adipocytes, and serum lipomics. Twenty-one overweight/obese children (9 boys and 12 girls, age 13.0 ± 0.5 yr, BMI 33.0 ± 1.8 kg/m(2)) were placed on a 2-wk ad libitum, high-fiber, low-fat diet and daily exercise regimen. Fasting serum samples were taken pre- and postintervention for determination of cytokines, metabolic risk markers, and lipomics. Monocytes and adipocytes were incubated with pre- and postintervention serum to investigate changes in cytokine secretion. Correlative associations were calculated, followed by hierarchical clustering to determine relationships between fatty acid (FA) species and clinical biomarkers. Despite remaining overweight/obese, interleukin (IL)-6, IL-8, TNFα, PAI-1, resistin, amylin, leptin, insulin, and IL-1ra decreased and adiponectin increased. Culture studies indicated decreases in monocyte secretion of IL-6, TNFα, and IL-1ß and adipocyte secretion of IL-6. Lipomic analysis revealed a decrease in total lipids and decreases in saturated FAs and an increase in 18:1/18:0. In general, Pearson's correlations revealed that inflammatory markers are negatively associated with a cluster of polyunsaturated FAs and positively correlated with several saturated FAs. These results indicate significant modification of multiple indices of metabolic health with short-term rigorous lifestyle modification in overweight/obese children prior to obesity reversal.


Assuntos
Adipócitos/metabolismo , Terapia por Exercício , Inflamação/terapia , Leucócitos Mononucleares/metabolismo , Sobrepeso/terapia , Adolescente , Biomarcadores/sangue , Biomarcadores/metabolismo , Glicemia/análise , Glicemia/metabolismo , Células Cultivadas , Criança , Citocinas/sangue , Citocinas/metabolismo , Jejum/sangue , Jejum/metabolismo , Ácidos Graxos/sangue , Ácidos Graxos/metabolismo , Feminino , Humanos , Masculino , Sobrepeso/sangue , Sobrepeso/metabolismo
15.
Ann Plast Surg ; 69(4): 435-8, 2012 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-22964665

RESUMO

BACKGROUND: Facial paralysis is a debilitating condition. Dynamic and static facial reanimation remains a challenge for plastic surgeons and requires important resources. Our objective was to quantify the health state utility assessment (ie, utility score outcomes) of living with unilateral facial paralysis. METHODS: Utility assessments using visual analog scale, time trade-off, and standard gamble were used to obtain utility outcome scores for unilateral facial paralysis from a prospective sample of the general population and medical students. RESULTS: A total number of 123 individuals prospectively participated in the study. All measures (visual analog scale, time trade-off, and standard gamble) for unilateral facial paralysis [0.56±0.18, 0.78±0.21, and 0.79±0.21 respectively] were significantly different (P<0.0001) from the corresponding outcome scores for monocular blindness [0.61±0.21, 0.83±0.21, and 0.85±0.18, respectively] and binocular blindness [0.33±0.18, 0.65±0.28, and 0.65±0.29, respectively]. Linear regression analysis using age, race, income, and education as predictors of each of the utility scores for facial paralysis showed no statistical significance. CONCLUSIONS: In samples of the general population and medical students, all utility score outcome measures for facial paralysis were lower than those for monocular blindness. Our sample population, if faced with unilateral facial paralysis, would theoretically undergo facial reanimation procedures with a willingness to sacrifice 8 years of life and be willing to undergo a procedure with a 21% chance of mortality to attain perfect health, respectively.


Assuntos
Atitude Frente a Saúde , Paralisia Facial/psicologia , Procedimentos Neurocirúrgicos/psicologia , Qualidade de Vida , Adolescente , Adulto , Paralisia Facial/cirurgia , Feminino , Pesquisas sobre Atenção à Saúde , Nível de Saúde , Humanos , Modelos Lineares , Masculino , Estudos Prospectivos , Anos de Vida Ajustados por Qualidade de Vida , Inquéritos e Questionários , Adulto Jovem
16.
Ann Plast Surg ; 69(4): 431-4, 2012 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-22964667

RESUMO

BACKGROUND: Revision rhinoplasty for functional deformities can be both an aesthetic and reconstructive surgical challenge. We set out to quantify the health state utility assessment of living with the physical appearance of nasal asymmetry along with having nasal obstruction. The use of utility scores has helped to establish the health burden of living with various medical conditions. We sought to quantify living with a health state of nasal asymmetry with nasal obstruction after primary rhinoplasty using utility outcome scores. METHODS: We used previously validated utility outcome measures to quantify the health burden of this clinical scenario in 128 prospective subjects. These subjects were from a sample of the population and medical students recruited to complete a survey to determine the utility outcome score of revision rhinoplasty using visual analog scale (VAS), time trade-off (TTO), and standard gamble (SG) tests to obtain utility scores for revision rhinoplasty. Linear regression and Student t test were used for statistical analysis. RESULTS: All measures (VAS, TTO, and SG) for functional nasal deformity (0.80±0.13, 0.90±0.12, and 0.91±0.13, respectively) of the 128 prospective subjects participating in this online study were significantly different (P<0.005) from the corresponding scores for monocular blindness (0.63±0.15, 0.85±0.16, and 0.85±0.19, respectively) and binocular blindness (0.38±0.18, 0.66±0.25, and 0.69±0.24, respectively). Being white was inversely related to the VAS utility scores for rhinoplasty (P<0.05). Additionally, female sex was positively correlated to the TTO score. Age, income, and education were not predictors of utility scores. CONCLUSIONS: In a sample of the population and medical students, VAS, TTO, and SG utility scores for revision rhinoplasty were determined and can be compared objectively with other health states and diseases with known utility scores. In a preoperative setting, women were objectively willing to potentially "trade" more years of life to treat a functional nasal deformity. If faced with a deformed nose after primary rhinoplasty, our sample population would consent to undergo a revision rhinoplasty procedure with a theoretical 9% chance of mortality and were willing to trade 3.6 years of their remaining life.


Assuntos
Atitude Frente a Saúde , Efeitos Psicossociais da Doença , Obstrução Nasal/cirurgia , Qualidade de Vida , Rinoplastia/psicologia , Adulto , Estética , Feminino , Pesquisas sobre Atenção à Saúde , Humanos , Modelos Lineares , Masculino , Obstrução Nasal/fisiopatologia , Obstrução Nasal/psicologia , Nariz/anatomia & histologia , Nariz/fisiopatologia , Nariz/cirurgia , Estudos Prospectivos , Anos de Vida Ajustados por Qualidade de Vida , Reoperação/psicologia , Resultado do Tratamento
17.
Pediatr Emerg Care ; 28(3): 288-91, 2012 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-22391929

RESUMO

Hand fractures are the most common site of injury in the pediatric population. They commonly involve the epiphyseal growth plates, and their standard classification is that of Salter-Harris (SH). Rotational deformities after SH fractures are rarely reported in literature. However, only 5 degrees of angulation can cause evident rotational deformity. This could be seen clinically and reconfirmed with radiologic evaluation. Up to this date, there are only a few cases of SH fractures with rotational deformity that have been described. We present 2 cases of SH type 2 with evidence of rotational deformity, which were reduced under local anesthesia in the emergency department. A review of literature is performed. Thus, examination for rotational deformities in SH fractures should be kept in mind. A satisfactory closed reduction under local anesthesia can be obtained.


Assuntos
Traumatismos dos Dedos/diagnóstico por imagem , Falanges dos Dedos da Mão/lesões , Fraturas Ósseas/diagnóstico por imagem , Fraturas Salter-Harris , Polegar/lesões , Acidentes por Quedas , Criança , Feminino , Traumatismos dos Dedos/terapia , Fraturas Ósseas/terapia , Humanos , Masculino , Radiografia
18.
Clin Anat ; 25(8): 966-8, 2012 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-22431308

RESUMO

Latissimus dorsi (LD) is the broadest muscle of the back responsible for extension and adduction of shoulder. The authors report a case of isolated unilateral absence of the latissimus dorsi muscle observed during an ablative surgical procedure and flap reconstruction. The left LD muscle was completely absent in our patient and no tendon fibers belonging to this muscle could be observable on further dissection. The surrounding muscle anatomy was normal and in place suggesting a developmental etiology for its absence. Awareness of this possible variation is of importance in considering reconstructive options.


Assuntos
Dorso/anatomia & histologia , Achados Incidentais , Músculo Esquelético/anormalidades , Ombro/anatomia & histologia , Idoso de 80 Anos ou mais , Neoplasias Ósseas/cirurgia , Feminino , Humanos , Músculo Esquelético/anatomia & histologia , Músculo Esquelético/diagnóstico por imagem , Procedimentos de Cirurgia Plástica , Sarcoma/cirurgia , Ombro/cirurgia , Tomografia Computadorizada por Raios X , Resultado do Tratamento
19.
Plast Reconstr Surg ; 149(3): 465e-474e, 2022 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-35196684

RESUMO

BACKGROUND: An amputation of the upper extremity not only is devastating for the patient's physical, emotional, and social well-being but also constitutes a financial stress for both the patient and the health care system. The objective of this study was to determine the utility and quality-adjusted life-years of hand allotransplantation versus myoelectric prostheses and to compare these measures in patients afflicted with unilateral versus bilateral amputations. METHODS: A survey was administered on bilateral amputees, unilateral amputees, replantation patients, and healthy controls. Patient demographics, functional patient-reported outcomes, quality-of-life questionnaires, and utility outcome measures were calculated for four different scenarios: hand transplantation and myoelectric prostheses with or without complications. RESULTS: Five bilateral amputees, 12 unilateral amputees, nine replantation patients, and 45 healthy controls completed the survey. The highest quality-adjusted life-years were obtained in the replantation patient group for the scenario of myoelectric prosthesis without complications (mean, 34.8 years). Altogether, there was no statistically significant difference between hand transplantation and myoelectric prostheses (p = 0.36). On subgroup analysis, unilateral amputees reported significantly higher quality-adjusted life-years for myoelectric prostheses rather than hand transplantation (6.4; p = 0.0015), whereas bilateral amputees did not demonstrate a significant difference (-2.4; p = 0.299). CONCLUSIONS: Utility and quality-adjusted life-years do not differ significantly between hand transplantation and myoelectric prostheses, except in unilateral amputees with myoelectric prostheses, who had higher quality-of-life scores. Based on trends from this pilot study, myoelectric prostheses may be considered for unilateral amputees, whereas no superiority can be demonstrated between both treatments in bilateral amputees. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III.


Assuntos
Amputação Traumática/cirurgia , Membros Artificiais , Transplante de Mão , Indicadores Básicos de Saúde , Medidas de Resultados Relatados pelo Paciente , Qualidade de Vida , Anos de Vida Ajustados por Qualidade de Vida , Adulto , Idoso , Estudos de Casos e Controles , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Projetos Piloto , Reimplante
20.
Pediatr Emerg Care ; 27(11): 1069-71, 2011 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-22068071

RESUMO

The boutonniere deformity (BD) is a well-described condition in hand surgery. Treatment of acute traumatic BD includes splinting of the proximal interphalangeal joint in extension for 4 to 5 weeks, which often leads to acceptable results. However, the chronic BD is more problematic and often requires surgical intervention with poor functional outcomes. Boutonniere deformity is extremely rare in the pediatric population. We present the case of a 9-year-old girl who presented to the emergency department with an acute traumatic BD after a fall. Being an uncommon entity in this patient population, the patient was referred to the plastic surgery clinic and was subsequently treated appropriately with splinting, resulting in favorable results as early as 4 weeks. To our knowledge, this is the first reported case of BD in the pediatric patient population. Recognition and timely management of BD in a pediatric patient should not be overlooked to obtain favorable results.


Assuntos
Traumatismos dos Dedos/complicações , Articulações dos Dedos/patologia , Deformidades Adquiridas da Mão/etiologia , Ferimentos não Penetrantes/complicações , Acidentes por Quedas , Criança , Erros de Diagnóstico , Emergências , Feminino , Fraturas Ósseas/diagnóstico , Deformidades Adquiridas da Mão/terapia , Humanos , Contenções
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