Detalhe da pesquisa
1.
Delayed administration of elezanumab, a human anti-RGMa neutralizing monoclonal antibody, promotes recovery following cervical spinal cord injury.
Neurobiol Dis
; 172: 105812, 2022 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35810963
2.
Intrathecal amyloid-beta oligomer administration increases tau phosphorylation in the medial temporal lobe in the African green monkey: A nonhuman primate model of Alzheimer's disease.
Neuropathol Appl Neurobiol
; 48(4): e12800, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35156715
3.
Elezanumab, a human anti-RGMa monoclonal antibody, promotes neuroprotection, neuroplasticity, and neurorecovery following a thoracic hemicompression spinal cord injury in non-human primates.
Neurobiol Dis
; 155: 105385, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33991647
4.
Delayed administration of the human anti-RGMa monoclonal antibody elezanumab promotes functional recovery including spontaneous voiding after spinal cord injury in rats.
Neurobiol Dis
; 143: 104995, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32590037
5.
Neutralizing RGMa with Elezanumab Promotes Cerebroprotection and Recovery in Rabbit Middle Cerebral Artery Occlusion.
Transl Stroke Res
; 2023 Jun 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-37326791
6.
Acute inhibition of 11beta-hydroxysteroid dehydrogenase type-1 improves memory in rodent models of cognition.
J Neurosci
; 31(14): 5406-13, 2011 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-21471376
7.
Effect of analgesic therapy on clinical outcome measures in a randomized controlled trial using client-owned dogs with hip osteoarthritis.
BMC Vet Res
; 8: 185, 2012 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-23035739
8.
Hepatic knockdown of stearoyl-CoA desaturase 1 via RNA interference in obese mice decreases lipid content and changes fatty acid composition.
Front Biosci
; 12: 3781-94, 2007 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17485339
9.
Discovery and metabolic stabilization of potent and selective 2-amino-N-(adamant-2-yl) acetamide 11beta-hydroxysteroid dehydrogenase type 1 inhibitors.
J Med Chem
; 50(1): 149-64, 2007 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-17201418
10.
Differential effects of domoic acid and E. coli lipopolysaccharide on tumor necrosis factor-alpha, transforming growth factor-beta1 and matrix metalloproteinase-9 release by rat neonatal microglia: evaluation of the direct activation hypothesis.
Mar Drugs
; 5(3): 113-35, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-18458762
11.
2,4-diaminopyrimidine derivatives as potent growth hormone secretagogue receptor antagonists.
J Med Chem
; 49(8): 2568-78, 2006 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-16610800
12.
Discovery and pharmacological evaluation of growth hormone secretagogue receptor antagonists.
J Med Chem
; 49(15): 4459-69, 2006 Jul 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-16854051
13.
Selective antagonism of the hepatic glucocorticoid receptor reduces hepatic glucose production.
Metabolism
; 55(9): 1255-62, 2006 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16919547
14.
Antidiabetic activity of passive nonsteroidal glucocorticoid receptor modulators.
J Med Chem
; 48(16): 5295-304, 2005 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-16078847
15.
A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects.
Mol Endocrinol
; 17(5): 860-9, 2003 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-12586843
16.
The Vasopressin 1b Receptor Antagonist A-988315 Blocks Stress Effects on the Retrieval of Object-Recognition Memory.
Neuropsychopharmacology
; 40(8): 1979-89, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25669604
17.
Liver-selective glucocorticoid antagonists: a novel treatment for type 2 diabetes.
J Med Chem
; 47(17): 4213-30, 2004 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-15293993
18.
Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines.
J Med Chem
; 46(6): 1016-30, 2003 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-12620078
19.
In vitro optimization of structure activity relationships of analogues of A-331440 combining radioligand receptor binding assays and micronucleus assays of potential antiobesity histamine H3 receptor antagonists.
Basic Clin Pharmacol Toxicol
; 95(3): 144-52, 2004 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15447739
20.
Potentiation of analgesic efficacy but not side effects: co-administration of an α4ß2 neuronal nicotinic acetylcholine receptor agonist and its positive allosteric modulator in experimental models of pain in rats.
Biochem Pharmacol
; 82(8): 967-76, 2011 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21620806