Detalhe da pesquisa
1.
Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates.
Nucleic Acids Res
; 2024 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38742636
2.
From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization.
Nucleic Acids Res
; 50(12): 6656-6670, 2022 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35736224
3.
Evaluation of RNAi therapeutics VIR-2218 and ALN-HBV for chronic hepatitis B: Results from randomized clinical trials.
J Hepatol
; 79(4): 924-932, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37290591
4.
Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing.
Nucleic Acids Res
; 49(18): 10250-10264, 2021 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34508350
5.
The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine-Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human.
Drug Metab Dispos
; 50(6): 781-797, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34154993
6.
Centyrin ligands for extrahepatic delivery of siRNA.
Mol Ther
; 29(6): 2053-2066, 2021 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33601052
7.
Investigating the pharmacodynamic durability of GalNAc-siRNA conjugates.
Nucleic Acids Res
; 48(21): 11827-11844, 2020 12 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32808038
8.
Safety evaluation of 2'-deoxy-2'-fluoro nucleotides in GalNAc-siRNA conjugates.
Nucleic Acids Res
; 47(7): 3306-3320, 2019 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30820542
9.
Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression.
Mol Ther
; 26(1): 105-114, 2018 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28988716
10.
Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates.
Mol Ther
; 26(3): 708-717, 2018 03 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29456020
11.
Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc-siRNA conjugates.
Nucleic Acids Res
; 45(19): 10969-10977, 2017 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28981809
12.
Post-Synthetic Modification of Oligonucleotides via Orthogonal Amidation and Copper Catalyzed Cycloaddition Reactions.
Bioconjug Chem
; 29(6): 1859-1865, 2018 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-29893553
13.
5'-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates.
Chembiochem
; 17(11): 985-9, 2016 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27121751
14.
High-throughput chemical modification of oligonucleotides for systematic structure-activity relationship evaluation.
Bioconjug Chem
; 25(12): 2222-32, 2014 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25398098
15.
Molecular umbrella conjugate for the ocular delivery of siRNA.
Bioconjug Chem
; 25(2): 197-201, 2014 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-24433067
16.
RNA interference in the era of nucleic acid therapeutics.
Nat Biotechnol
; 42(3): 394-405, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38409587
17.
RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes.
Nat Commun
; 14(1): 1970, 2023 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37031257
18.
In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene.
bioRxiv
; 2023 Jul 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-37546995
19.
Effective siRNA delivery and target mRNA degradation using an amphipathic peptide to facilitate pH-dependent endosomal escape.
Biochem J
; 435(2): 475-87, 2011 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21265735
20.
Evaluation of efficacy, biodistribution, and inflammation for a potent siRNA nanoparticle: effect of dexamethasone co-treatment.
Mol Ther
; 18(1): 171-80, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19738601