Detalhe da pesquisa
1.
Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma.
Bioorg Med Chem Lett
; 29(16): 2294-2301, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31307887
2.
Preclinical profile of BI 224436, a novel HIV-1 non-catalytic-site integrase inhibitor.
Antimicrob Agents Chemother
; 58(6): 3233-44, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24663024
3.
Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding.
ACS Med Chem Lett
; 15(6): 864-872, 2024 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38894924
4.
Structure-based design of novel HCV NS5B thumb pocket 2 allosteric inhibitors with submicromolar gt1 replicon potency: discovery of a quinazolinone chemotype.
Bioorg Med Chem Lett
; 23(14): 4132-40, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23768906
5.
Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors.
Bioorg Med Chem Lett
; 23(9): 2585-9, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23545108
6.
Anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors with sub-micromolar potency in the cell-based replicon assay.
Bioorg Med Chem Lett
; 23(24): 6879-85, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24176401
7.
Importance of ligand bioactive conformation in the discovery of potent indole-diamide inhibitors of the hepatitis C virus NS5B.
J Am Chem Soc
; 132(43): 15204-12, 2010 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-20942454
8.
N-Acetamideindolecarboxylic acid allosteric 'finger-loop' inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies.
Bioorg Med Chem Lett
; 20(3): 857-61, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20074949
9.
Investigation on the role of the tetrazole in the binding of thiotetrazolylacetanilides with HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases.
Bioorg Med Chem Lett
; 19(4): 1199-205, 2009 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19138518
10.
Aligning Potency and Pharmacokinetic Properties for Pyridine-Based NCINIs.
ACS Med Chem Lett
; 7(8): 797-801, 2016 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27563405
11.
Ligand bioactive conformation plays a critical role in the design of drugs that target the hepatitis C virus NS3 protease.
J Med Chem
; 57(5): 1777-89, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24144444
12.
Conformation-based restrictions and scaffold replacements in the design of hepatitis C virus polymerase inhibitors: discovery of deleobuvir (BI 207127).
J Med Chem
; 57(5): 1845-54, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24159919
13.
Enantiomeric atropisomers inhibit HCV polymerase and/or HIV matrix: characterizing hindered bond rotations and target selectivity.
J Med Chem
; 57(5): 1944-51, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24024973
14.
Integrated strategies for identifying leads that target the NS3 helicase of the hepatitis C virus.
J Med Chem
; 57(5): 2074-90, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24467709
15.
Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV.
ACS Med Chem Lett
; 5(6): 711-6, 2014 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24944749
16.
Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1.
ACS Med Chem Lett
; 5(4): 422-7, 2014 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900852
17.
Revealing atropisomer axial chirality in drug discovery.
ChemMedChem
; 6(3): 505-13, 2011 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21360821
18.
Development of specific "drug-like property" rules for carboxylate-containing oral drug candidates.
ChemMedChem
; 5(12): 2102-13, 2010 Dec 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-20979082
19.
Binding mode determination of benzimidazole inhibitors of the hepatitis C virus RNA polymerase by a structure and dynamics strategy.
Angew Chem Int Ed Engl
; 43(33): 4306-11, 2004 Aug 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-15368379
20.
Optimization and determination of the absolute configuration of a series of potent inhibitors of human papillomavirus type-11 E1-E2 protein-protein interaction: a combined medicinal chemistry, NMR and computational chemistry approach.
Bioorg Med Chem
; 15(7): 2690-700, 2007 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17306550