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1.
Nat Immunol ; 20(3): 373, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30728492

RESUMO

In the version of this article initially published, a source of funding was not included in the Acknowledgements section. That section should include the following: P.J.M.O. was supported by EU FP7 PREPARE project 602525. The error has been corrected in the HTML and PDF version of the article.

2.
Nat Immunol ; 19(6): 625-635, 2018 06.
Artigo em Inglês | MEDLINE | ID: mdl-29777224

RESUMO

Transcriptional profiles and host-response biomarkers are used increasingly to investigate the severity, subtype and pathogenesis of disease. We now describe whole-blood mRNA signatures and concentrations of local and systemic immunological mediators in 131 adults hospitalized with influenza, from whom extensive clinical and investigational data were obtained by MOSAIC investigators. Signatures reflective of interferon-related antiviral pathways were common up to day 4 of symptoms in patients who did not require mechanical ventilator support; in those who needed mechanical ventilation, an inflammatory, activated-neutrophil and cell-stress or death ('bacterial') pattern was seen, even early in disease. Identifiable bacterial co-infection was not necessary for this 'bacterial' signature but was able to enhance its development while attenuating the early 'viral' signature. Our findings emphasize the importance of timing and severity in the interpretation of host responses to acute viral infection and identify specific patterns of immune-system activation that might enable the development of novel diagnostic and therapeutic tools for severe influenza.


Assuntos
Biomarcadores/sangue , Influenza Humana/sangue , Influenza Humana/imunologia , Transcriptoma , Adolescente , Adulto , Idoso , Progressão da Doença , Feminino , Humanos , Influenza Humana/genética , Interferons/sangue , Interferons/imunologia , Masculino , Pessoa de Meia-Idade , Neutrófilos/imunologia , RNA Mensageiro/sangue , Adulto Jovem
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