Detalhe da pesquisa
1.
Effect of the L74I Polymorphism on Fitness of Cabotegravir-Resistant Variants of Human Immunodeficiency Virus 1 Subtype A6.
J Infect Dis
; 228(10): 1352-1356, 2023 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37497681
2.
Phase IIa Proof-of-Concept Evaluation of the Antiviral Efficacy, Safety, Tolerability, and Pharmacokinetics of the Next-Generation Maturation Inhibitor GSK3640254.
Clin Infect Dis
; 75(5): 786-794, 2022 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34996113
3.
GSK3640254 Is a Novel HIV-1 Maturation Inhibitor with an Optimized Virology Profile.
Antimicrob Agents Chemother
; 66(1): e0187621, 2022 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34780263
4.
Impact of Integrase Sequences from HIV-1 Subtypes A6/A1 on the In Vitro Potency of Cabotegravir or Rilpivirine.
Antimicrob Agents Chemother
; 66(3): e0170221, 2022 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34978890
5.
Discovery of a novel and potent class of anti-HIV-1 maturation inhibitors with improved virology profile against gag polymorphisms.
Bioorg Med Chem Lett
; 27(12): 2689-2694, 2017 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28454672
6.
Naphthyridinone (NTD) integrase inhibitors 4. Investigating N1 acetamide substituent effects with C3 amide groups.
Bioorg Med Chem Lett
; 24(14): 3104-7, 2014 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24908608
7.
Naphthyridinone (NTD) integrase inhibitors: N1 protio and methyl combination substituent effects with C3 amide groups.
Bioorg Med Chem Lett
; 23(2): 422-5, 2013 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23245515
8.
Combining symmetry elements results in potent naphthyridinone (NTD) HIV-1 integrase inhibitors.
Bioorg Med Chem Lett
; 21(21): 6461-4, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21945283
9.
The heptad repeat 2 domain is a major determinant for enhanced human immunodeficiency virus type 1 (HIV-1) fusion and pathogenicity of a highly pathogenic HIV-1 Env.
J Virol
; 83(22): 11715-25, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19726524
10.
1,3,4-Oxadiazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 2: SAR of the C5 position.
Bioorg Med Chem Lett
; 19(6): 1807-10, 2009 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19217284
11.
The use of oxadiazole and triazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 1: Establishing the pharmacophore.
Bioorg Med Chem Lett
; 19(6): 1802-6, 2009 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19217781
12.
Modulation of NFAT-dependent gene expression by the RhoA signaling pathway in T cells.
J Leukoc Biol
; 82(2): 361-9, 2007 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-17502338
13.
HIV type 1 from a patient with baseline resistance to CCR5 antagonists uses drug-bound receptor for entry.
AIDS Res Hum Retroviruses
; 26(1): 13-24, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20055594
14.
Synthesis and antiviral activity of 7-benzyl-4-hydroxy-1,5-naphthyridin-2(1H)-one HIV integrase inhibitors.
J Med Chem
; 52(9): 2754-61, 2009 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-19374386
15.
Dioxolane guanosine 5'-triphosphate, an alternative substrate inhibitor of wild-type and mutant HIV-1 reverse transcriptase. Steady state and pre-steady state kinetic analyses.
J Biol Chem
; 278(21): 18971-9, 2003 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-12651859