RESUMO
PURPOSE: Patients treated with direct oral anticoagulants (DOACs) frequently undergo interventional procedures requiring temporary discontinuation of anticoagulant therapy. Little is known about remaining peri-procedural exposure to rivaroxaban in real-world patients. METHODS: Fifty-six patients with rivaroxaban treatment and scheduled cardiac catheterization were included in this prospective, observational, and single-center study. Rivaroxaban concentrations were determined by LC-MS/MS and a chromogenic anti-Xa assay. Population pharmacokinetic modeling was carried out on LC-MS/MS concentration data using NONMEM software, and results were applied to Monte Carlo simulations to predict appropriate rivaroxaban discontinuation intervals. RESULTS: Rivaroxaban concentrations ranged from Assuntos
Cateterismo Cardíaco
, Inibidores do Fator Xa/sangue
, Inibidores do Fator Xa/farmacocinética
, Período Pré-Operatório
, Rivaroxabana/sangue
, Rivaroxabana/farmacocinética
, Idoso
, Cromatografia Líquida
, Inibidores do Fator Xa/efeitos adversos
, Feminino
, Hemorragia/induzido quimicamente
, Humanos
, Masculino
, Pessoa de Meia-Idade
, Modelos Biológicos
, Método de Monte Carlo
, Dinâmica não Linear
, Rivaroxabana/efeitos adversos
, Espectrometria de Massas em Tandem
RESUMO
Vector-borne diseases can be contracted by exposure to contaminated material. This mode of transmission is not geographically restricted to the presence of a vector. Unexpected infection in regions of low incidence potentially delays diagnosis. We report a case of severe falciparum malaria following nosocomial Plasmodium falciparum transmission in nonendemic Germany.