Towards biochips using microstructured optical fiber sensors.

In this paper we present the first incorporation of a microstructured optical fiber (MOF) into biochip applications. A 16-mm-long piece of MOF is incorporated into an optic-fluidic coupler chip, which is fabricated in PMMA polymer using a CO(2) laser. The developed chip configuration allows the continuous control of liquid flow through the MOF and simultaneous optical characterization. While integrated in the chip, the MOF is functionalized towards the capture of a specific single-stranded DNA string by immobilizing a sensing layer on the microstructured internal surfaces of the fiber. The sensing layer contains the DNA string complementary to the target DNA sequence and thus operates through the highly selective DNA hybridization process. Optical detection of the captured DNA was carried out using the evanescent-wave-sensing principle. Owing to the small size of the chip, the presented technique allows for analysis of sample volumes down to 300 nL and the fabrication of miniaturized portable devices.

Polarization control method for ultraviolet writing of advanced Bragg gratings.

We present a flexible and simple method for UV writing of Bragg gratings with advanced apodization profiles including discrete phase shifts. The method is based on a p phase shift between the refractive-index modulation profiles induced by s and p polarization of UV light. By changing the ratio of UV intensity in the two polarizations we are able to control the modulation strength and to induce phase shifts while keeping a constant effective refractive index throughout the Bragg grating. We demonstrate strong UV-written Bragg gratings with Gaussian or sinc apodizations with spectral shapes, in good agreement with theoretical predictions.

Fabrication of advanced Bragg gratings with complex apodization profiles by use of the polarization control method.

The polarization control method offers a flexible, robust, and low-cost route for the parallel fabrication of gratings with complex apodization profiles including several discrete phase shifts and chirp. The performance of several test gratings is evaluated in terms of their spectral response and compared with theoretical predictions. Short gratings with sidelobe-suppression levels in excess of 32 dB and transmission dips lower than 80 dB have been realized. Finally, most of the devices fabricated by the polarization control method show comparable quality to gratings manufactured by far more complex methods.