Detalhe da pesquisa
1.
Hepatitis C Virus Genotype 1 to 6 Protease Inhibitor Escape Variants: In Vitro Selection, Fitness, and Resistance Patterns in the Context of the Infectious Viral Life Cycle.
Antimicrob Agents Chemother
; 60(6): 3563-78, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27021330
2.
Substitutions at NS3 Residue 155, 156, or 168 of Hepatitis C Virus Genotypes 2 to 6 Induce Complex Patterns of Protease Inhibitor Resistance.
Antimicrob Agents Chemother
; 59(12): 7426-36, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26392503
3.
Differential sensitivity of 5'UTR-NS5A recombinants of hepatitis C virus genotypes 1-6 to protease and NS5A inhibitors.
Gastroenterology
; 146(3): 812-821.e4, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24262279
4.
Highly efficient infectious cell culture of three hepatitis C virus genotype 2b strains and sensitivity to lead protease, nonstructural protein 5A, and polymerase inhibitors.
Hepatology
; 59(2): 395-407, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23913364
5.
Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system.
Proc Natl Acad Sci U S A
; 109(48): 19757-62, 2012 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-23151512
6.
Combination treatment with hepatitis C virus protease and NS5A inhibitors is effective against recombinant genotype 1a, 2a, and 3a viruses.
Antimicrob Agents Chemother
; 57(3): 1291-303, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23274664
7.
Adapted J6/JFH1-based Hepatitis C virus recombinants with genotype-specific NS4A show similar efficacies against lead protease inhibitors, alpha interferon, and a putative NS4A inhibitor.
Antimicrob Agents Chemother
; 57(12): 6034-49, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24060868